Acyl-CoA synthase ACSL4: an essential target in ferroptosis and fatty acid metabolism

• Published in: Chinese medical journal Vol. 136; no. 21; pp. 2521 - 2537
• Main Authors: Ding, Kaiyue, Liu, Chongbin, Li, Li, Yang, Ming, Jiang, Na, Luo, Shilu, Sun, Lin
• Format: Journal Article
• Language: English
• Published: China Lippincott Williams & Wilkins 05.11.2023; Lippincott Williams & Wilkins Ovid Technologies; Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410000, China%Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan 410000, China; Wolters Kluwer
• Subjects: Adenosine; Cholesterol; Fatty acids; Ferroptosis; Hypoxia; Intellectual disabilities; Kinases; Lipids; Metabolism; MicroRNAs; Oxidation; Phosphatase; Polyunsaturated fatty acids; Proteins; Review; Ferroptosis; Metabolic diseases; Long-chain acyl-coenzyme A (CoA) synthase 4 (ACSL4); Fatty acid metabolism; Ischemia/reperfusion; Cancer

Long-chain acyl-coenzyme A (CoA) synthase 4 (ACSL4) is an enzyme that esterifies CoA into specific polyunsaturated fatty acids, such as arachidonic acid and adrenic acid. Based on accumulated evidence, the ACSL4-catalyzed biosynthesis of arachidonoyl-CoA contributes to the execution of ferroptosis b...