Stem Cells and the Regeneration of the Aging Cardiovascular System

• Published in: Circulation research Vol. 100; no. 8; pp. 1116 - 1127
• Main Authors: Ballard, Victoria L.T., Edelberg, Jay M.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 27.04.2007; Lippincott
• Subjects: Aging - pathology; Aging - physiology; Animals; Biological and medical sciences; Cardiovascular Diseases - pathology; Cardiovascular Diseases - physiopathology; Cardiovascular Physiological Phenomena; Cardiovascular System - cytology; Cardiovascular System - pathology; Cellular Senescence - physiology; Fundamental and applied biological sciences. Psychology; Humans; Regeneration - physiology; Stem Cells - cytology; Stem Cells - physiology; Vertebrates: cardiovascular system; Endothelial cell; Senescence; Stem cell; Ageing; Precursor cell; endothelial progenitor cell; Regeneration; Vertebrata; Mammalia; cardiac stem cell; Circulatory system; aging; Progenitor cell

It is well established that cardiovascular repair mechanisms become progressively impaired with age and that advanced age is itself a significant risk factor for cardiovascular disease. Although therapeutic developments have improved the prognosis for those with cardiovascular disease, mortality rat...