4,5-Dihydro-1,2,3-oxadiazole: A Very Elusive Key Intermediate in Various Important Chemical Transformations

• Published in: Chemistry : a European journal Vol. 21; no. 43; pp. 15092 - 15099
• Main Authors: Banert, Klaus, Singh, Neeraj, Fiedler, Benjamin, Friedrich, Joachim, Korb, Marcus, Lang, Heinrich
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 19.10.2015; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Alkenes; Alkoxides; Alkylation; Biomedical materials; Chemistry; Chemists; cycloreversion; Dealkylation; Decomposition; Intermediates; Ketones; Low temperature; Magnetic resonance spectroscopy; NMR; NMR spectroscopy; Nuclear magnetic resonance; nucleophilic substitution; Oxadiazoles; reactive intermediates; Surgical implants; Thallium; Transformations; alkylation; cycloreversion; NMR spectroscopy; reactive intermediates; nucleophilic substitution

4,5‐Dihydro‐1,2,3‐oxadiazoles are postulated to be key intermediates in the industrial synthesis of ketones from alkenes, in the alkylation of DNA in vivo, and in the decomposition of N‐nitrosoureas; they are also a subject of great interest for theoretical chemists. In the presented report, the for...