A versatile drug delivery system targeting senescent cells - Muñoz‐Espín, Daniel; Rovira, Miguel; Galiana, Irene; Giménez, Cristina; Lozano‐Torres, Beatriz; Paez‐Ribes, Marta; Llanos, Susana; Chaib, Selim; Muñoz‐Martín, Maribel; Ucero, Alvaro C; Garaulet, Guillermo; Mulero, Francisca; et al. (EMBO molecular medicine, 2018)
Keywords: Aging; Animals; beta-Galactosidase - metabolism; Cell Survival - drug effects; Cellular Senescence - drug effects; Chemotherapy; Collagen; Cytotoxicity; Cytotoxins - administration & dosage; Cytotoxins - pharmacology; Disease Models, Animal; Doxorubicin; Drug Compounding; Drug delivery; Drug Delivery Systems; Drug development; Drugs; EMBO01; EMBO28; Encapsulation; Fibrosis; Fluorescent Dyes - metabolism; Fluorophores; Galactose - metabolism; Heterografts; Intravenous administration; Lung diseases; Lysosomes; Lysosomes - enzymology; Mice; nanomedicine; Neoplasm Transplantation; Neoplasms - drug therapy; Oligosaccharides; Oligosaccharides - metabolism; palbociclib; Piperazines - administration & dosage; Piperazines - pharmacology; Pyridines - administration & dosage; Pyridines - pharmacology; Research Article; Respiratory function; Senescence; Staining and Labeling; Therapeutic applications; Thrombocytopenia; Tropism; Tumor cells; Tumors; Xenografts; β-Galactosidase; senescence; nanomedicine; fibrosis; chemotherapy; palbociclib