Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease

• Published in: Alzheimer's & dementia Vol. 15; no. 1; pp. 8 - 16
• Main Authors: Bell, W. Robert, An, Yang, Kageyama, Yusuke, English, Collin, Rudow, Gay L., Pletnikova, Olga, Thambisetty, Madhav, O'Brien, Richard, Moghekar, Abhay R., Albert, Marilyn S., Rabins, Peter V., Resnick, Susan M., Troncoso, Juan C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2019
• Subjects: Aged, 80 and over; Aging; Aging - pathology; Alzheimer disease (AD); Alzheimer Disease - genetics; Alzheimer Disease - pathology; Apolipoprotein E4 - genetics; Autopsy; Baltimore; Brain; Cognitive Dysfunction - genetics; Dementia; Genotype; Humans; Longitudinal Studies; Memory; Mild Cognitive Impairment (MCI); Neurofibrillary tangles; Neuropathology; Neuropsychological Tests; Primary Age-Related Tauopathy (PART); Public Health Planning; Tauopathies - genetics; Baltimore; Neurofibrillary tangles; Primary Age-Related Tauopathy (PART); Aging; Alzheimer disease (AD); Mild Cognitive Impairment (MCI); Public Health Planning; Dementia
• ISSN: 1552-5260; 1552-5279; 1552-5279
• DOI: 10.1016/j.jalz.2018.07.215

Primary age-related tauopathy (PART) is a recently described entity that can cause cognitive impairment in the absence of Alzheimer's disease (AD). Here, we compared neuropathological features, tau haplotypes, apolipoprotein E (APOE) genotypes, and cognitive profiles in age-matched subjects wit...