Sigma‐1 receptor attenuates osteoclastogenesis by promoting ER‐associated degradation of SERCA2

• Published in: EMBO molecular medicine Vol. 14; no. 7; pp. e15373 - n/a
• Main Authors: Wei, Xiaoan, Zheng, Zeyu, Feng, Zhenhua, Zheng, Lin, Tao, Siyue, Zheng, Bingjie, Huang, Bao, Zhang, Xuyang, Liu, Junhui, Chen, Yilei, Zong, Wentian, Shan, Zhi, Fan, Shunwu, Chen, Jian, Zhao, Fengdong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.07.2022; EMBO Press; John Wiley and Sons Inc; Springer Nature
• Subjects: Agonists; Animals; Bone mass; Bone turnover; Ca2+-transporting ATPase; Degradation; dimemorfan; Disease; EMBO25; Endoplasmic reticulum; Endoplasmic Reticulum-Associated Degradation; ER‐associated degradation; Genotype & phenotype; Homeostasis; Immunoprecipitation; Ligands; Mice; Mitochondria; Oophorectomy; Osteoclastogenesis; Osteogenesis; Osteoporosis; Ovariectomy; Phenotypes; Phosphatase; Proteasomes; Proteins; Receptors, sigma - genetics; Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism; SERCA2; Sigma-1 Receptor; Surgery; Ubiquitination; SERCA2; dimemorfan; Sigma‐1 receptor; ER‐associated degradation; osteoporosis; Sigma-1 receptor; ER-associated degradation

Sigma‐1 receptor (Sigmar1) is a specific chaperone located in the mitochondria‐associated endoplasmic reticulum membrane (MAM) and plays a role in several physiological processes. However, the role of Sigmar1 in bone homeostasis remains unknown. Here, we show that mice lacking Sigmar1 exhibited seve...