Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability

Dyslexia is a complex neurodevelopmental disorder characterized by impaired reading ability despite normal intellect, and is associated with specific difficulties in phonological and rapid auditory processing (RAP), visual attention and working memory. Genetic variants in Doublecortin domain‐contain...

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Published inGenes, brain and behavior Vol. 13; no. 8; pp. 802 - 811
Main Authors Truong, D. T., Che, A., Rendall, A. R., Szalkowski, C. E., LoTurco, J. J., Galaburda, A. M., Holly Fitch, R.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.11.2014
John Wiley & Sons, Inc
Subjects
Animals
Auditory Perception - genetics
Auditory Perceptual Disorders - genetics
Behavior, Animal - physiology
Brain
Children & youth
Dcdc2
Dyslexia
language impairment
Male
Maze Learning - physiology
Memory - physiology
Mice
Mice, Knockout
Microtubule-Associated Proteins - genetics
Motor Skills - physiology
Mutation
Phonetics
rapid auditory processing
Rotarod Performance Test
working memory
Dcdc2
rapid auditory processing
working memory
language impairment
dyslexia
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Abstract Dyslexia is a complex neurodevelopmental disorder characterized by impaired reading ability despite normal intellect, and is associated with specific difficulties in phonological and rapid auditory processing (RAP), visual attention and working memory. Genetic variants in Doublecortin domain‐containing protein 2 (DCDC2) have been associated with dyslexia, impairments in phonological processing and in short‐term/working memory. The purpose of this study was to determine whether sensory and behavioral impairments can result directly from mutation of the Dcdc2 gene in mice. Several behavioral tasks, including a modified pre‐pulse inhibition paradigm (to examine auditory processing), a 4/8 radial arm maze (to assess/dissociate working vs. reference memory) and rotarod (to examine sensorimotor ability and motor learning), were used to assess the effects of Dcdc2 mutation. Behavioral results revealed deficits in RAP, working memory and reference memory in Dcdc2del2/del2 mice when compared with matched wild types. Current findings parallel clinical research linking genetic variants of DCDC2 with specific impairments of phonological processing and memory ability. Dcdc2 mutant mice show impaired working and reference memory performance on a 4/8 radial arm water maze.
AbstractList Dyslexia is a complex neurodevelopmental disorder characterized by impaired reading ability despite normal intellect, and is associated with specific difficulties in phonological and rapid auditory processing (RAP), visual attention and working memory. Genetic variants in Doublecortin domain-containing protein 2 (DCDC2) have been associated with dyslexia, impairments in phonological processing and in short-term/working memory. The purpose of this study was to determine whether sensory and behavioral impairments can result directly from mutation of the Dcdc2 gene in mice. Several behavioral tasks, including a modified pre-pulse inhibition paradigm (to examine auditory processing), a 4/8 radial arm maze (to assess/dissociate working vs. reference memory) and rotarod (to examine sensorimotor ability and motor learning), were used to assess the effects of Dcdc2 mutation. Behavioral results revealed deficits in RAP, working memory and reference memory in Dcdc2del2/del2 mice when compared with matched wild types. Current findings parallel clinical research linking genetic variants of DCDC2 with specific impairments of phonological processing and memory ability.
Dyslexia is a complex neurodevelopmental disorder characterized by impaired reading ability despite normal intellect, and is associated with specific difficulties in phonological and rapid auditory processing (RAP), visual attention and working memory. Genetic variants in Doublecortin domain-containing protein 2 (DCDC2) have been associated with dyslexia, impairments in phonological processing and in short-term/working memory. The purpose of this study was to determine whether sensory and behavioral impairments can result directly from mutation of the Dcdc2 gene in mice. Several behavioral tasks, including a modified pre-pulse inhibition paradigm (to examine auditory processing), a 4/8 radial arm maze (to assess/dissociate working vs. reference memory) and rotarod (to examine sensorimotor ability and motor learning), were used to assess the effects of Dcdc2 mutation. Behavioral results revealed deficits in RAP, working memory and reference memory in Dcdc2del2/del2 mice when compared with matched wild types. Current findings parallel clinical research linking genetic variants of DCDC2 with specific impairments of phonological processing and memory ability. Dcdc2 mutant mice show impaired working and reference memory performance on a 4/8 radial arm water maze.
Dyslexia is a complex neurodevelopmental disorder characterized by impaired reading ability despite normal intellect, and is associated with specific difficulties in phonological and rapid auditory processing, visual attention, and working memory. Genetic variants in DCDC2 have been associated with dyslexia, impairments in phonological processing, and in short term/working memory. The purpose of this study was to determine whether sensory and behavioral impairments can result directly from mutation of the Dcdc2 gene in mice. Several behavioral tasks, including a modified pre-pulse inhibition paradigm (to examine auditory processing), a 4/8 radial arm maze (to assess/dissociate working versus reference memory), and rotarod (to examine sensorimotor ability and motor learning) were used to assess the effects of Dcdc2 mutation. Behavioral results revealed deficits in rapid auditory processing, working memory, and reference memory in Dcdc2 del2/del2 mice as compared to matched wild types. Current findings parallel clinical research linking genetic variants of DCDC2 with specific impairments of phonological processing and memory ability.
Dyslexia is a complex neurodevelopmental disorder characterized by impaired reading ability despite normal intellect, and is associated with specific difficulties in phonological and rapid auditory processing (RAP), visual attention and working memory. Genetic variants in Doublecortin domain‐containing protein 2 ( DCDC2 ) have been associated with dyslexia, impairments in phonological processing and in short‐term/working memory. The purpose of this study was to determine whether sensory and behavioral impairments can result directly from mutation of the Dcdc2 gene in mice. Several behavioral tasks, including a modified pre‐pulse inhibition paradigm (to examine auditory processing), a 4/8 radial arm maze (to assess/dissociate working vs. reference memory) and rotarod (to examine sensorimotor ability and motor learning), were used to assess the effects of Dcdc2 mutation. Behavioral results revealed deficits in RAP, working memory and reference memory in Dcdc2 del2/del2 mice when compared with matched wild types. Current findings parallel clinical research linking genetic variants of DCDC2 with specific impairments of phonological processing and memory ability.
Dyslexia is a complex neurodevelopmental disorder characterized by impaired reading ability despite normal intellect, and is associated with specific difficulties in phonological and rapid auditory processing (RAP), visual attention and working memory. Genetic variants in Doublecortin domain‐containing protein 2 (DCDC2) have been associated with dyslexia, impairments in phonological processing and in short‐term/working memory. The purpose of this study was to determine whether sensory and behavioral impairments can result directly from mutation of the Dcdc2 gene in mice. Several behavioral tasks, including a modified pre‐pulse inhibition paradigm (to examine auditory processing), a 4/8 radial arm maze (to assess/dissociate working vs. reference memory) and rotarod (to examine sensorimotor ability and motor learning), were used to assess the effects of Dcdc2 mutation. Behavioral results revealed deficits in RAP, working memory and reference memory in Dcdc2del2/del2 mice when compared with matched wild types. Current findings parallel clinical research linking genetic variants of DCDC2 with specific impairments of phonological processing and memory ability. Dcdc2 mutant mice show impaired working and reference memory performance on a 4/8 radial arm water maze.
Dyslexia is a complex neurodevelopmental disorder characterized by impaired reading ability despite normal intellect, and is associated with specific difficulties in phonological and rapid auditory processing (RAP), visual attention and working memory. Genetic variants in Doublecortin domain-containing protein 2 (DCDC2) have been associated with dyslexia, impairments in phonological processing and in short-term/working memory. The purpose of this study was to determine whether sensory and behavioral impairments can result directly from mutation of the Dcdc2 gene in mice. Several behavioral tasks, including a modified pre-pulse inhibition paradigm (to examine auditory processing), a 4/8 radial arm maze (to assess/dissociate working vs. reference memory) and rotarod (to examine sensorimotor ability and motor learning), were used to assess the effects of Dcdc2 mutation. Behavioral results revealed deficits in RAP, working memory and reference memory in Dcdc2(del2/del2) mice when compared with matched wild types. Current findings parallel clinical research linking genetic variants of DCDC2 with specific impairments of phonological processing and memory ability.
Author Szalkowski, C. E.
Truong, D. T.
LoTurco, J. J.
Holly Fitch, R.
Che, A.
Rendall, A. R.
Galaburda, A. M.
AuthorAffiliation 2 Department of Physiology and Neurobiology, University of Connecticut, 75 North Eagleville Road, Unit 3156, Storrs, CT 06269
3 Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215
1 Department of Psychology/Behavioral Neuroscience, University of Connecticut, 406 Babbidge Road, Unit 1020, Storrs, CT 06269
AuthorAffiliation_xml – name: 2 Department of Physiology and Neurobiology, University of Connecticut, 75 North Eagleville Road, Unit 3156, Storrs, CT 06269
– name: 1 Department of Psychology/Behavioral Neuroscience, University of Connecticut, 406 Babbidge Road, Unit 1020, Storrs, CT 06269
– name: 3 Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215
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Cites_doi 10.1016/j.bbr.2011.01.048
10.1523/JNEUROSCI.4205-12.2013
10.1016/0093-934X(80)90139-X
10.1371/journal.pone.0020580
10.1159/000348431
10.1016/j.neuroscience.2008.01.020
10.1080/87565640802418662
10.1016/j.biopsych.2013.08.018
10.1016/j.neuron.2011.11.002
10.1016/S0006-8993(97)01417-0
10.1016/S0163-1047(80)90430-6
10.1016/S0167-8760(00)00152-5
10.3109/00207450903275129
10.4161/cc.5.9.2715
10.1523/JNEUROSCI.5996-10.2012
10.1038/nature02033
10.1037/h0077516
10.1523/JNEUROSCI.4166-08.2008
10.1016/j.ajhg.2013.05.008
10.1016/0028-3932(79)90042-3
10.1038/ejhg.2009.237
10.1016/j.neuropharm.2010.08.012
10.1097/YPG.0b013e32834acdb2
10.1016/S0166-4328(02)00098-0
10.1007/s10519-010-9408-3
10.1086/498992
10.1093/cercor/bht028
10.1111/j.1601-183X.2010.00662.x
10.1098/rspb.1996.0142
10.1073/pnas.240461697
10.1016/j.biopsych.2012.05.008
10.1093/cercor/bht104
10.1016/0166-4328(96)00034-4
10.1111/j.1467-7687.2007.00546.x
10.1016/j.nbd.2009.12.022
10.1007/s11682-007-9012-1
10.1016/j.ijdevneu.2012.01.009
10.1073/pnas.0508591102
10.1016/S0896-6273(00)80778-3
10.1016/j.brainresbull.2006.11.005
10.1111/j.1601-183X.2011.00727.x
10.1016/j.neuroscience.2011.06.010
10.1016/0896-6273(95)90304-6
10.1210/en.2012-2056
10.1016/j.neuroimage.2012.06.037
10.1016/j.neuron.2010.09.017
10.1016/j.biopsych.2011.02.005
10.1111/j.1467-9450.2010.00808.x
10.1016/j.brainresbull.2007.07.013
10.1016/j.neuron.2012.12.032
10.1152/jn.00092.2013
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Keywords Dcdc2
rapid auditory processing
working memory
language impairment
dyslexia
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References 2010; 59
2006; 78
2010; 18
2014; 24
2011; 10
2008; 76
2008; 33
1996; 263
2011; 190
2007; 75
2008; 2
2001; 40
2012; 72
2010; 68
2005; 102
2011; 70
2011; 72
2000; 97
2008; 28
2011; 22
2013; 110
2013; 154
2008; 152
2010b; 120
2012; 63
1978; 92
1979; 17
2010; 38
2010a; 51
1980; 29
1995; 14
2002; 136
1999; 23
2006; 5
2013; 93
2007; 10
2011; 6
2012; 32
2012; 30
2003; 425
2013; 33
2013; 77
2013; 35
2011; 41
1998; 785
1980; 9
1996; 80
2014; 76
2011; 220
21698230 - PLoS One. 2011;6(6):e20580
20097287 - Neurobiol Dis. 2010 May;38(2):167-72
7363063 - Brain Lang. 1980 Mar;9(2):182-98
19096528 - Brain Imaging Behav. 2008 Mar;2(1):21-26
16278297 - Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17053-8
21689730 - Neuroscience. 2011 Sep 8;190:398-408
22196341 - Neuron. 2011 Dec 22;72(6):1080-90
19005912 - Dev Neuropsychol. 2008;33(6):707-44
20732335 - Neuropharmacology. 2010 Dec;59(7-8):605-11
21457949 - Biol Psychiatry. 2011 Aug 1;70(3):237-45
23599167 - Cereb Cortex. 2014 Sep;24(9):2489-501
22683091 - Biol Psychiatry. 2012 Oct 15;72(8):671-6
14586460 - Nature. 2003 Oct 30;425(6961):917-25
16385449 - Am J Hum Genet. 2006 Jan;78(1):52-62
23426677 - J Neurosci. 2013 Feb 20;33(8):3500-4
12385788 - Behav Brain Res. 2002 Oct 17;136(1):31-49
16628014 - Cell Cycle. 2006 May;5(9):976-83
20128672 - Int J Neurosci. 2010 Jan;120(1):51-9
22750057 - Neuroimage. 2012 Oct 15;63(1):148-56
7417203 - Behav Neural Biol. 1980 Jul;29(3):405-9
8805833 - Proc Biol Sci. 1996 Aug 22;263(1373):961-5
17286846 - Dev Sci. 2007 Mar;10(2):213-36
23746548 - Am J Hum Genet. 2013 Jul 11;93(1):19-28
19036962 - J Neurosci. 2008 Nov 26;28(48):12691-9
24094509 - Biol Psychiatry. 2014 Sep 1;76(5):387-96
8905142 - Behav Brain Res. 1996 Oct;80(1-2):185-94
20068590 - Eur J Hum Genet. 2010 Jun;18(6):668-73
18395604 - Brain Res Bull. 2008 May 15;76(1-2):1-7
7695894 - Neuron. 1995 Mar;14(3):477-85
10399933 - Neuron. 1999 Jun;23(2):257-71
11095716 - Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13907-12
20977651 - Genes Brain Behav. 2011 Mar;10(2):244-52
22262880 - J Neurosci. 2012 Jan 18;32(3):817-25
23392256 - Endocrinology. 2013 Mar;154(3):1337-48
21040854 - Neuron. 2010 Nov 4;68(3):557-69
20338015 - Scand J Psychol. 2010 Jun 1;51(3):192-202
23439125 - Neuron. 2013 Feb 20;77(4):736-49
755058 - J Comp Physiol Psychol. 1978 Dec;92(6):1119-27
21295619 - Behav Brain Res. 2011 Jul 7;220(2):263-70
23596332 - J Neurophysiol. 2013 Jul;110(1):177-89
21881542 - Psychiatr Genet. 2012 Feb;22(1):25-30
9518631 - Brain Res. 1998 Mar 2;785(2):236-44
23594585 - Dev Neurosci. 2013;35(1):50-68
21883923 - Genes Brain Behav. 2011 Nov;10(8):868-75
18313856 - Neuroscience. 2008 Mar 27;152(3):723-33
22326444 - Int J Dev Neurosci. 2012 Jun;30(4):293-302
21042874 - Behav Genet. 2011 Jan;41(1):58-66
17259020 - Brain Res Bull. 2007 Mar 15;71(5):508-14
23395846 - Cereb Cortex. 2014 Jul;24(7):1753-66
522981 - Neuropsychologia. 1979;17(6):669-82
11166109 - Int J Psychophysiol. 2001 Feb;40(1):77-87
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References_xml – volume: 72
  start-page: 671
  year: 2012
  end-page: 676
  article-title: Three dyslexia susceptibility genes, DYX1C1, DCDC2, and KIAA0319, affect temporo‐parietal white matter structure
  publication-title: Biol Psychiatry
– volume: 22
  start-page: 25
  year: 2011
  end-page: 30
  article-title: DCDC2 genetic variants and susceptibility to developmental dyslexia
  publication-title: Psychiatr Genet
– volume: 40
  start-page: 77
  year: 2001
  end-page: 87
  article-title: Speech perception deficit in dyslexic adults as measured by mismatch negativity (MMN)
  publication-title: Int J Psychophysiol
– volume: 32
  start-page: 817
  year: 2012
  end-page: 825
  article-title: Genetic variants of FOXP2 and KIAA0319/TTRAP/THEM2 locus are associated with altered brain activation in distinct language‐related regions
  publication-title: J Neurosci
– volume: 77
  start-page: 736
  year: 2013
  end-page: 749
  article-title: NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex
  publication-title: Neuron
– volume: 120
  start-page: 51
  year: 2010b
  end-page: 59
  article-title: Working memory deficit in dyslexia: behavioral and fMRI evidence
  publication-title: Int J Neurosci
– volume: 17
  start-page: 669
  year: 1979
  end-page: 682
  article-title: Spatial memory and hippocampal function
  publication-title: Neuropsychologia
– volume: 33
  start-page: 707
  year: 2008
  end-page: 744
  article-title: A multidisciplinary approach to understanding developmental dyslexia within working‐memory architecture: genotypes, phenotypes, brain, and instruction
  publication-title: Dev Neuropsychol
– volume: 2
  start-page: 21
  year: 2008
  end-page: 26
  article-title: Polymorphism of DCDC2 reveals differences in cortical morphology of healthy individuals – a preliminary voxel based morphometry study
  publication-title: Brain Imaging Behav
– volume: 78
  start-page: 52
  year: 2006
  end-page: 62
  article-title: Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia
  publication-title: Am J Hum Genet
– volume: 30
  start-page: 293
  year: 2012
  end-page: 302
  article-title: Neocortical disruption and behavioral impairments in rats following in utero RNAi of candidate dyslexia risk gene Kiaa0319
  publication-title: Int J Dev Neurosci
– volume: 10
  start-page: 868
  year: 2011
  end-page: 875
  article-title: Mutation of the dyslexia‐associated gene Dcdc2 impairs LTM and visuo‐spatial performance in mice
  publication-title: Genes Brain Behav
– volume: 154
  start-page: 1337
  year: 2013
  end-page: 1348
  article-title: Delayed puberty but normal fertility in mice with selective deletion of insulin receptors from Kiss1 cells
  publication-title: Endocrinology
– volume: 24
  start-page: 2489
  year: 2014
  end-page: 2501
  article-title: Altered neuronal response during rapid auditory processing and its relation to phonological processing in prereading children at familial risk for dyslexia
  publication-title: Cereb Cortex
– volume: 110
  start-page: 177
  year: 2013
  end-page: 189
  article-title: Cortical speech‐evoked response patterns in multiple auditory fields are correlated with behavioral discrimination ability
  publication-title: J Neurophysiol
– volume: 102
  start-page: 17053
  year: 2005
  end-page: 17058
  article-title: DCDC2 is associated with reading disability and modulates neuronal development in the brain
  publication-title: Proc Natl Acad Sci USA
– volume: 220
  start-page: 263
  year: 2011
  end-page: 270
  article-title: Resting frontal gamma power at 16, 24 and 36 months predicts individual differences in language and cognition at 4 and 5 years
  publication-title: Behav Brain Res
– volume: 72
  start-page: 1080
  year: 2011
  end-page: 1090
  article-title: Altered low‐gamma sampling in auditory cortex accounts for the three main facets of dyslexia
  publication-title: Neuron
– volume: 28
  start-page: 12691
  year: 2008
  end-page: 12699
  article-title: A neonatal ventral hippocampal lesion causes functional deficits in adult prefrontal cortical interneurons
  publication-title: J Neurosci
– volume: 38
  start-page: 167
  year: 2010
  end-page: 172
  article-title: The role of primary cilia in neuronal function
  publication-title: Neurobiol Dis
– volume: 6
  start-page: e20580
  year: 2011
  article-title: Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons
  publication-title: PLoS One
– volume: 59
  start-page: 605
  year: 2010
  end-page: 611
  article-title: Selective deficits in spatial working memory in the neonatal ventral hippocampal lesion rat model of schizophrenia
  publication-title: Neuropharmacology
– volume: 70
  start-page: 237
  year: 2011
  end-page: 245
  article-title: DCDC2, KIAA0319 and CMIP are associated with reading‐related traits
  publication-title: Biol Psychiatry
– volume: 63
  start-page: 148
  year: 2012
  end-page: 156
  article-title: Variants in the DYX2 locus are associated with altered brain activation in reading‐related brain regions in subjects with reading disability
  publication-title: Neuroimage
– volume: 33
  start-page: 3500
  year: 2013
  end-page: 3504
  article-title: Unstable representation of sound: a biological marker of dyslexia
  publication-title: J Neurosci
– volume: 10
  start-page: 213
  year: 2007
  end-page: 236
  article-title: Infant information processing and family history of specific language impairment: converging evidence for RAP deficits from two paradigms
  publication-title: Dev Sci
– volume: 263
  start-page: 961
  year: 1996
  end-page: 965
  article-title: Auditory temporal coding in dyslexia
  publication-title: Proc Biol Sci
– volume: 29
  start-page: 405
  year: 1980
  end-page: 409
  article-title: Hippocampus: cognitive map or working memory?
  publication-title: Behav Neural Biol
– volume: 23
  start-page: 257
  year: 1999
  end-page: 271
  article-title: Doublecortin is a microtubule‐associated protein and is expressed widely by migrating neurons
  publication-title: Neuron
– volume: 92
  start-page: 1119
  year: 1978
  end-page: 1127
  article-title: Selective hippocampal lesions: differential effects on performance by rats of a spatial task with preoperative versus postoperative training
  publication-title: J Comp Physiol Psychol
– volume: 9
  start-page: 182
  year: 1980
  end-page: 198
  article-title: Auditory temporal perception, phonics, and reading disabilities in children
  publication-title: Brain Lang
– volume: 190
  start-page: 398
  year: 2011
  end-page: 408
  article-title: Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin
  publication-title: Neuroscience
– volume: 152
  start-page: 723
  year: 2008
  end-page: 733
  article-title: Postnatal analysis of the effect of embryonic knockdown and overexpression of candidate dyslexia susceptibility gene homolog Dcdc2 in the rat
  publication-title: Neuroscience
– volume: 35
  start-page: 50
  year: 2013
  end-page: 68
  article-title: Knockdown of the candidate dyslexia susceptibility gene homolog Dyx1c1 inrodents: effects on auditory processing, visual attention, and cortical and thalamic anatomy
  publication-title: Dev Neurosci
– volume: 5
  start-page: 976
  year: 2006
  end-page: 983
  article-title: The DCX superfamily 1: common and divergent roles for members of the mouse DCX superfamily
  publication-title: Cell Cycle
– volume: 785
  start-page: 236
  year: 1998
  end-page: 244
  article-title: Water version of the radial‐arm maze: learning in three inbred strains of mice
  publication-title: Brain Res
– volume: 41
  start-page: 58
  year: 2011
  end-page: 66
  article-title: A dyslexia‐associated variant in DCDC2 changes gene expression
  publication-title: Behav Genet
– volume: 76
  start-page: 387
  year: 2014
  end-page: 396
  article-title: The dyslexia‐associated gene Dcdc2 is required for spike‐timing precision in mouse neocortex
  publication-title: Biol Psychiatry
– volume: 136
  start-page: 31
  year: 2002
  end-page: 49
  article-title: Infant discrimination of rapid auditory cues predicts later language impairment
  publication-title: Behav Brain Res
– volume: 75
  start-page: 508
  year: 2007
  end-page: 514
  article-title: Developmental disruptions and behavioral impairments in rats following in utero RNAi of Dyx1c1
  publication-title: Brain Res Bull
– volume: 93
  start-page: 19
  year: 2013
  end-page: 28
  article-title: Alleles of a polymorphic ETV6 binding site in DCDC2 confer risk of reading and language impairment
  publication-title: Am J Hum Genet
– volume: 14
  start-page: 477
  year: 1995
  end-page: 485
  article-title: Cellular basis of working memory
  publication-title: Neuron
– volume: 24
  start-page: 1753
  year: 2014
  end-page: 1766
  article-title: Knockdown of the dyslexia‐associated gene Kiaa0319 impairs temporal responses to speech stimuli in rat primary auditory cortex
  publication-title: Cereb Cortex
– volume: 425
  start-page: 917
  year: 2003
  end-page: 925
  article-title: A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
  publication-title: Nature
– volume: 10
  start-page: 244
  year: 2011
  end-page: 252
  article-title: Persistent spatial working memory deficits in rats following in utero RNAi of Dyx1c1
  publication-title: Genes Brain Behav
– volume: 97
  start-page: 13907
  year: 2000
  end-page: 13912
  article-title: Disruption of the neural response to rapid acoustic stimuli in dyslexia: evidence from functional MRI
  publication-title: Proc Natl Acad Sci USA
– volume: 80
  start-page: 185
  year: 1996
  end-page: 194
  article-title: Reference memory and allocentric spatial localization deficits after unilateral cortical brain injury in the rat
  publication-title: Behav Brain Res
– volume: 51
  start-page: 192
  year: 2010a
  end-page: 202
  article-title: Executive working memory processes in dyslexia: behavioral and fMRI evidence
  publication-title: Scand J Psychol
– volume: 68
  start-page: 557
  year: 2010
  end-page: 569
  article-title: NMDA receptor ablation on parvalbumin‐positive interneurons impairs hippocampal synchrony, spatial representations, and working memory
  publication-title: Neuron
– volume: 76
  start-page: 1
  year: 2008
  end-page: 7
  article-title: Use of a modified prepulse inhibition paradigm to assess complex auditory discrimination in rodents
  publication-title: Brain Res Bull
– volume: 18
  start-page: 668
  year: 2010
  end-page: 673
  article-title: Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample
  publication-title: Eur J Hum Genet
– ident: e_1_2_5_20_1
  doi: 10.1016/j.bbr.2011.01.048
– ident: e_1_2_5_21_1
  doi: 10.1523/JNEUROSCI.4205-12.2013
– ident: e_1_2_5_47_1
  doi: 10.1016/0093-934X(80)90139-X
– ident: e_1_2_5_29_1
  doi: 10.1371/journal.pone.0020580
– ident: e_1_2_5_46_1
  doi: 10.1159/000348431
– ident: e_1_2_5_7_1
  doi: 10.1016/j.neuroscience.2008.01.020
– ident: e_1_2_5_5_1
  doi: 10.1080/87565640802418662
– ident: e_1_2_5_10_1
  doi: 10.1016/j.biopsych.2013.08.018
– ident: e_1_2_5_26_1
  doi: 10.1016/j.neuron.2011.11.002
– ident: e_1_2_5_22_1
  doi: 10.1016/S0006-8993(97)01417-0
– ident: e_1_2_5_34_1
  doi: 10.1016/S0163-1047(80)90430-6
– ident: e_1_2_5_41_1
  doi: 10.1016/S0167-8760(00)00152-5
– ident: e_1_2_5_4_1
  doi: 10.3109/00207450903275129
– ident: e_1_2_5_13_1
  doi: 10.4161/cc.5.9.2715
– ident: e_1_2_5_36_1
  doi: 10.1523/JNEUROSCI.5996-10.2012
– ident: e_1_2_5_19_1
  doi: 10.1038/nature02033
– ident: e_1_2_5_23_1
  doi: 10.1037/h0077516
– volume: 28
  start-page: 12691
  year: 2008
  ident: e_1_2_5_50_1
  article-title: A neonatal ventral hippocampal lesion causes functional deficits in adult prefrontal cortical interneurons
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4166-08.2008
  contributor:
    fullname: Tseng K.Y.
– ident: e_1_2_5_37_1
  doi: 10.1016/j.ajhg.2013.05.008
– ident: e_1_2_5_35_1
  doi: 10.1016/0028-3932(79)90042-3
– ident: e_1_2_5_27_1
  doi: 10.1038/ejhg.2009.237
– ident: e_1_2_5_6_1
  doi: 10.1016/j.neuropharm.2010.08.012
– ident: e_1_2_5_28_1
  doi: 10.1097/YPG.0b013e32834acdb2
– ident: e_1_2_5_2_1
  doi: 10.1016/S0166-4328(02)00098-0
– ident: e_1_2_5_33_1
  doi: 10.1007/s10519-010-9408-3
– ident: e_1_2_5_42_1
  doi: 10.1086/498992
– ident: e_1_2_5_8_1
  doi: 10.1093/cercor/bht028
– ident: e_1_2_5_44_1
  doi: 10.1111/j.1601-183X.2010.00662.x
– ident: e_1_2_5_30_1
  doi: 10.1098/rspb.1996.0142
– ident: e_1_2_5_48_1
  doi: 10.1073/pnas.240461697
– ident: e_1_2_5_14_1
  doi: 10.1016/j.biopsych.2012.05.008
– ident: e_1_2_5_39_1
  doi: 10.1093/cercor/bht104
– ident: e_1_2_5_43_1
  doi: 10.1016/0166-4328(96)00034-4
– ident: e_1_2_5_11_1
  doi: 10.1111/j.1467-7687.2007.00546.x
– ident: e_1_2_5_25_1
  doi: 10.1016/j.nbd.2009.12.022
– ident: e_1_2_5_31_1
  doi: 10.1007/s11682-007-9012-1
– ident: e_1_2_5_45_1
  doi: 10.1016/j.ijdevneu.2012.01.009
– ident: e_1_2_5_32_1
  doi: 10.1073/pnas.0508591102
– ident: e_1_2_5_17_1
  doi: 10.1016/S0896-6273(00)80778-3
– ident: e_1_2_5_49_1
  doi: 10.1016/j.brainresbull.2006.11.005
– ident: e_1_2_5_16_1
  doi: 10.1111/j.1601-183X.2011.00727.x
– ident: e_1_2_5_51_1
  doi: 10.1016/j.neuroscience.2011.06.010
– ident: e_1_2_5_18_1
  doi: 10.1016/0896-6273(95)90304-6
– ident: e_1_2_5_38_1
  doi: 10.1210/en.2012-2056
– ident: e_1_2_5_12_1
  doi: 10.1016/j.neuroimage.2012.06.037
– ident: e_1_2_5_24_1
  doi: 10.1016/j.neuron.2010.09.017
– ident: e_1_2_5_40_1
  doi: 10.1016/j.biopsych.2011.02.005
– ident: e_1_2_5_3_1
  doi: 10.1111/j.1467-9450.2010.00808.x
– ident: e_1_2_5_15_1
  doi: 10.1016/j.brainresbull.2007.07.013
– ident: e_1_2_5_52_1
  doi: 10.1016/j.neuron.2012.12.032
– ident: e_1_2_5_9_1
  doi: 10.1152/jn.00092.2013
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Snippet Dyslexia is a complex neurodevelopmental disorder characterized by impaired reading ability despite normal intellect, and is associated with specific...
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pubmed
wiley
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SubjectTerms Animals
Auditory Perception - genetics
Auditory Perceptual Disorders - genetics
Behavior, Animal - physiology
Brain
Children & youth
Dcdc2
Dyslexia
language impairment
Male
Maze Learning - physiology
Memory - physiology
Mice
Mice, Knockout
Microtubule-Associated Proteins - genetics
Motor Skills - physiology
Mutation
Phonetics
rapid auditory processing
Rotarod Performance Test
working memory
Title Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fgbb.12170
https://www.ncbi.nlm.nih.gov/pubmed/25130614
https://www.proquest.com/docview/1626718707/abstract/
https://search.proquest.com/docview/1627071956
https://search.proquest.com/docview/1635040660
https://pubmed.ncbi.nlm.nih.gov/PMC4241168
Volume 13
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