肺癌患者外周血中循环肿瘤细胞与D-二聚体纤维蛋白原及血小板的关系
目的探讨肺癌患者外周血中循环肿瘤细胞（CTC）与D-二聚体（D—D）、纤维蛋白原（FIB）及血小板（PIJT）间的关系。方法收集79例原发初治肺癌患者的临床病理资料，采集患者清晨空腹时肘静脉血，检测患者外周血中D—D、FIB和PLT水平，应用免疫磁珠阴性分离及免疫细胞化学染色方法检测CTC的表达，分析D．D、FIB和PLT水平与CTC及肺癌患者临床病理特征的关系。结果79例肺癌患者外周血中D—D、FIB和PLT水平分别为（1．74±2．04）mg／L、（3．51±1．46）g／L和（3114-139）×10／L。其中D．D水平与肺癌患者远处转移情况有关（P=0．046），FIB水平与肺癌患者临...
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| Published in | 中华肿瘤杂志 Vol. 38; no. 5; pp. 368 - 371 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
新疆维吾尔自治区人民医院放疗二科, 乌鲁木齐,830001%832008,石河子大学医学院第一附属医院肿瘤内科
2016
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| Abstract | 目的探讨肺癌患者外周血中循环肿瘤细胞（CTC）与D-二聚体（D—D）、纤维蛋白原（FIB）及血小板（PIJT）间的关系。方法收集79例原发初治肺癌患者的临床病理资料，采集患者清晨空腹时肘静脉血，检测患者外周血中D—D、FIB和PLT水平，应用免疫磁珠阴性分离及免疫细胞化学染色方法检测CTC的表达，分析D．D、FIB和PLT水平与CTC及肺癌患者临床病理特征的关系。结果79例肺癌患者外周血中D—D、FIB和PLT水平分别为（1．74±2．04）mg／L、（3．51±1．46）g／L和（3114-139）×10／L。其中D．D水平与肺癌患者远处转移情况有关（P=0．046），FIB水平与肺癌患者临床分期、远处转移情况有关（均P〈0．05），PTJT水平与肺癌患者年龄、临床分期和远处转移情况有关（均P〈0．05）。79例肺癌患者中，CTC阳性45例，CTC阴性34例。CTC阳性患者的D．D、FIB、PLT水平分别为（2．31±2．41）mg／L、（3．79±1．56）g／L和（338±130）×10／L，CTC阴性患者的D—D、FIB、PLT水平分别为（0．99±1．02）mg／L、（3．14±1．25）gL和（229±129）×10／L，差异有统计学意义（均P〈0．05）。有远处转移患者的CTC阳性率（82．8％，24／29）明显高于无远处转移患者（42．0％，21／50），差异有统计学意义（P〈0．001）。有远处转移患者的D—D、FIB、PLT水平分别为（2．33±1．95）mg／L、（4．13±1．43）g／L和（433±74）×10。／L，无远处转移患者的D—D、FIB、PLT水平分别为（1．40±2．03）mg／L、（3．15±1．37）g／L和（206±88）×10／L，差异有统计学意义（均P〈O．05）。结论CTC可提早预测肺癌的远处转移，而血液高凝状态可能更易促进肺癌远处转移的发生。 |
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| AbstractList | 目的探讨肺癌患者外周血中循环肿瘤细胞（CTC）与D-二聚体（D—D）、纤维蛋白原（FIB）及血小板（PIJT）间的关系。方法收集79例原发初治肺癌患者的临床病理资料，采集患者清晨空腹时肘静脉血，检测患者外周血中D—D、FIB和PLT水平，应用免疫磁珠阴性分离及免疫细胞化学染色方法检测CTC的表达，分析D．D、FIB和PLT水平与CTC及肺癌患者临床病理特征的关系。结果79例肺癌患者外周血中D—D、FIB和PLT水平分别为（1．74±2．04）mg／L、（3．51±1．46）g／L和（3114-139）×10／L。其中D．D水平与肺癌患者远处转移情况有关（P=0．046），FIB水平与肺癌患者临床分期、远处转移情况有关（均P〈0．05），PTJT水平与肺癌患者年龄、临床分期和远处转移情况有关（均P〈0．05）。79例肺癌患者中，CTC阳性45例，CTC阴性34例。CTC阳性患者的D．D、FIB、PLT水平分别为（2．31±2．41）mg／L、（3．79±1．56）g／L和（338±130）×10／L，CTC阴性患者的D—D、FIB、PLT水平分别为（0．99±1．02）mg／L、（3．14±1．25）gL和（229±129）×10／L，差异有统计学意义（均P〈0．05）。有远处转移患者的CTC阳性率（82．8％，24／29）明显高于无远处转移患者（42．0％，21／50），差异有统计学意义（P〈0．001）。有远处转移患者的D—D、FIB、PLT水平分别为（2．33±1．95）mg／L、（4．13±1．43）g／L和（433±74）×10。／L，无远处转移患者的D—D、FIB、PLT水平分别为（1．40±2．03）mg／L、（3．15±1．37）g／L和（206±88）×10／L，差异有统计学意义（均P〈O．05）。结论CTC可提早预测肺癌的远处转移，而血液高凝状态可能更易促进肺癌远处转移的发生。 目的：探讨肺癌患者外周血中循环肿瘤细胞（ CTC）与D?二聚体（ D?D）、纤维蛋白原（FIB）及血小板（PLT）间的关系。方法收集79例原发初治肺癌患者的临床病理资料，采集患者清晨空腹时肘静脉血，检测患者外周血中D?D、FIB和PLT水平，应用免疫磁珠阴性分离及免疫细胞化学染色方法检测CTC的表达，分析D?D、FIB和PLT水平与CTC及肺癌患者临床病理特征的关系。结果79例肺癌患者外周血中D?D、FIB和PLT水平分别为（1．74±2．04）mg／L、（3．51±1．46）g／L和（311±139）×109／L。其中D?D水平与肺癌患者远处转移情况有关（P＝0．046），FIB水平与肺癌患者临床分期、远处转移情况有关（均P＜0．05），PLT水平与肺癌患者年龄、临床分期和远处转移情况有关（均P＜0．05）。79例肺癌患者中，CTC阳性45例，CTC阴性34例。 CTC阳性患者的D?D、FIB、PLT水平分别为（2．31±2．41）mg／L、（3．79±1．56）g／L和（338±130）×109／L，CTC阴性患者的D?D、FIB、PLT水平分别为（0．99±1．02）mg／L、（3．14±1．25）g／L和（229±129）×109／L，差异有统计学意义（均P＜0．05）。有远处转移患者的CTC阳性率（82．8％，24／29）明显高于无远处转移患者（42．0％，21／50），差异有统计学意义（P＜0．001）。有远处转移患者的D?D、FIB、PLT水平分别为（2．33±1．95）mg／L、（4．13±1．43）g／L和（433±74）×109／L，无远处转移患者的D?D、FIB、PLT水平分别为（1．40±2．03）mg／L、（3．15±1．37）g／L和（206±88）×109／L，差异有统计学意义（均P＜0．05）。结论 CTC可提早预测肺癌的远处转移，而血液高凝状态可能更易促进肺癌远处转移的发生。 |
| Abstract_FL | Objective To investigate the relationship between the presence of circulating tumor cells ( CTC) and the values of coagulation factors including D?dimer ( D?D) , fibrinogen ( FIB) and platelet ( PLT) in primary lung cancer patients. Methods Peripheral venous blood samples were collected from 79 patients with previously untreated primary lung cancer. The levels of D?D, FIB and PLT were detected. The CTCs were enriched by negative immunomagnetic separation with anti?CD45 antibody and then detected by immunocytochemistry with Anti?pan Cytokeratin antibody. The relationship between these parameters and clinicopathologic characteristics of the patients was analyzed. Results The levels of D?D, FIB and PLT were( 1.74±2.04) mg/L, ( 3. 51 ± 1. 46 ) g/L, ( 311 ± 139) × 109/L, respectively. The level of D?D was associated with distant metastasis of lung cancer (P=0.046). The level of FIB was associated with clinical stage and distant metastasis ( P<0.05) . The level of PLT was associated with age, clinical stage and distant metastasis (all P<0.05). Among the 79 patients, there were 45 CTC?positive and 34 CTC?negative cases. The levels of D?D in the CTC?positive and CTC?negative groups were (2.31±2.41)mg/L and (0.99±1.02) mg/L, those of FIB were (3.79±1.56)g/L and (3.14±1.25)g/L, and those of PLT were (338±130)×109/L and (229±129)×109/L, respectively(P<0.05 for all). The positive rate of CTC was significantly higher in the metastasis group (82.8%), significantly higher than that in the non?metastatic group (42.0%,P<0.001). The levels of D?D, FIB and PLT in the metastasis group were (2.33±1.95)mg/L, (4.13±1.43)g/L and (433±74)×109/L, but were (1.40±2.03) mg/L, (3.15±1.37)g/L and (206±88)×109/L in the non?metastatic group ( P<0.05 for all) . Conclusions The detection of circulating tumor cells may facilitate early prediction of distant metastasis of lung cancer. The hypercoagulation state is more?likely correlated with the distant metastasis of lung cancer. |
| Author | 刘春花 巩平 杨杰 |
| AuthorAffiliation | 新疆维吾尔自治区人民医院放疗二科,乌鲁木齐830001 石河子大学医学院第一附属医院肿瘤内科,832008 |
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| Author_FL | Liu Chunhua Yang Jie Gong Ping |
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| Keywords | Blood platelets D-二聚体 肿瘤转移 Fibrinogen D-dimer 纤维蛋白原 血小板 Circulating tumor cells Metastasis 肺肿瘤 Subject words] Lung neoplasms 循环肿瘤细胞 |
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| Notes | Objective To investigate the relationship between the presence of circulating tumor cells （CTC） and the values of coagulation factors including D-dimer （D-D）, fibrinogen （FIB） and platelet （PLT） in primary lung cancer patients. Methods Peripheral venous blood samples were collected from 79 patients with previously untreated primary lung cancer. The levels of D-D, FIB and PLT were detected. The CTCs were enriched by negative immunomagnetic separation with anti-CD45 antibody and then detected by immunocytochemistry with Anti-pan Cytokeratin antibody. The relationship between these parameters and clinicopathologic characteristics of the patients was analyzed. Results The levels of D-D, FIB and PLT were（1.74±2.04） mg/L, （ 3.51 ± 1.46 ） g/L, （ 311 ± 139） x 109/L, respectively. The level of D-D was associated with distant metastasis of lung cancer （P= 0.046）. The level of FIB was associated with clinical stage and distant metastasis （P〈0.05）. The level of PLT was associated with age, clinical stage and distant meta |
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| PublicationYear | 2016 |
| Publisher | 新疆维吾尔自治区人民医院放疗二科, 乌鲁木齐,830001%832008,石河子大学医学院第一附属医院肿瘤内科 |
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| SubjectTerms | D-二聚体 循环肿瘤细胞 纤维蛋白原 肺肿瘤 肿瘤转移 血小板 |
| Title | 肺癌患者外周血中循环肿瘤细胞与D-二聚体纤维蛋白原及血小板的关系 |
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