Clinical and immunologic effects of H1 antihistamine preventive medication during honeybee venom immunotherapy

• Published in: Journal of allergy and clinical immunology Vol. 122; no. 5; pp. 1001 - 1007.e4
• Main Authors: Müller, Ulrich R., MD, Jutel, Marek, MD, Reimers, Andrea, MD, Zumkehr, Judith, Sci Tec, Huber, Clarissa, MD, Kriegel, Carola, MD, Steiner, Urs, MD, Haeberli, Gabrielle, MD, Akdis, Mübeccel, MD, PhD, Helbling, Arthur, MD, Schnyder, Benno, MD, Blaser, Kurt, PhD, Akdis, Cezmi, MD
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.11.2008; Elsevier Limited
• Subjects: Adolescent; Adult; Allergies; Allergy and Immunology; antihistamine preventive medication; Apis mellifera; Bee Venoms - adverse effects; Bee Venoms - immunology; Bees; Blood pressure; Cetirizine - immunology; Cetirizine - therapeutic use; Cytokines; Desensitization, Immunologic - adverse effects; Double-Blind Method; Female; Histamine H1 Antagonists - immunology; Histamine H1 Antagonists - therapeutic use; histamine receptors; Humans; Hypersensitivity - etiology; Hypersensitivity - immunology; Hypersensitivity - prevention & control; Intensive care; Lymphocytes; Male; Middle Aged; Prospective Studies; T cells; Venom; Venom immunotherapy; Young Adult; BVIT; TT; Venom immunotherapy; PLA; SAR; antihistamine preventive medication; HR; T cells; Skin test end point concentration; Systemic allergic reaction; STEPC; SE; BV; Honeybee venom immunotherapy; Phospholipase A 2, a major allergen of honeybee venom; LC; Tetanus toxoid; cytokines; Honeybee venom; Histamine receptor; histamine receptors; Levocetirizine; Side effect

Background H1 antihistamines increase safety during allergen-specific immunotherapy and might influence the outcome because of immunoregulatory effects. Objective We sought to analyze the influence of 5 mg of levocetirizine (LC) on the safety, efficacy, and immunologic effects of ultrarush honeybee...