Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging

• Published in: Nature communications Vol. 8; no. 1; p. 14293
• Main Authors: Cuccarese, Michael F., Dubach, J. Matthew, Pfirschke, Christina, Engblom, Camilla, Garris, Christopher, Miller, Miles A., Pittet, Mikael J., Weissleder, Ralph
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.02.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 14/19; 14/34; 631/67/1059/602; 631/67/1612; 631/67/2321; 631/67/327; 631/67/580; 64/60; Aminopyridines - pharmacology; Aminopyridines - therapeutic use; Animals; Antibodies; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Biology; Cancer; Carcinoma, Lewis Lung - diagnostic imaging; Carcinoma, Lewis Lung - drug therapy; Carcinoma, Lewis Lung - immunology; Carcinoma, Lewis Lung - pathology; Cell Line, Tumor; Female; Humanities and Social Sciences; Humans; Imaging, Three-Dimensional - methods; Kinases; Labeling; Lung - diagnostic imaging; Lung - pathology; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - drug therapy; Lung Neoplasms - immunology; Lung Neoplasms - pathology; Macrophage Colony-Stimulating Factor - immunology; Macrophage Colony-Stimulating Factor - metabolism; Macrophages - drug effects; Macrophages - immunology; Metastasis; Mice; Mice, Inbred C57BL; Microscopy; Microscopy, Confocal - methods; Microscopy, Fluorescence - methods; multidisciplinary; Nanoparticles; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Neurosciences; Perfusion - methods; Pyrroles - pharmacology; Pyrroles - therapeutic use; RAW 264.7 Cells; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - immunology; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - metabolism; Science; Science (multidisciplinary); Signal Transduction - drug effects; Tomography, X-Ray Computed; Treatment Outcome; Tumor Burden - drug effects; Tumor Burden - immunology; Tumor Microenvironment - drug effects; Tumor Microenvironment - immunology; Tumors; Xenograft Model Antitumor Assays; United States > US; Massachusetts

Involvement of the immune system in tumour progression is at the forefront of cancer research. Analysis of the tumour immune microenvironment has yielded a wealth of information on tumour biology, and alterations in some immune subtypes, such as tumour-associated macrophages (TAM), can be strong pro...