Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages

• Published in: Nature communications Vol. 7; no. 1; pp. 11284 - 12
• Main Authors: Canton, Johnathan, Schlam, Daniel, Breuer, Christian, Gütschow, Michael, Glogauer, Michael, Grinstein, Sergio
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.04.2016; Nature Publishing Group; Nature Portfolio
• Subjects: 1-Phosphatidylinositol 3-kinase; 631/250/2504/342; 631/80/313/1461; 631/80/86/1999; Actin; Animals; Antigen presentation; Antigens; Calcium; Calcium (extracellular); Calcium - metabolism; Calcium signalling; Calcium-sensing receptors; Cdc42 protein; Cytoskeleton - metabolism; Cytosol - metabolism; Dendritic cells; Extracellular Space - metabolism; G protein-coupled receptors; Growth factors; GTP-Binding Protein alpha Subunits - metabolism; HEK293 Cells; Humanities and Social Sciences; Humans; Intracellular Space - metabolism; Kinases; Ligands; Macrophages; Macrophages - metabolism; Mice; Monocytes - cytology; multidisciplinary; NOD2 protein; Nod2 Signaling Adaptor Protein - metabolism; Pattern recognition; Phosphatidylinositol 3-Kinases - metabolism; Phospholipase; Phospholipase C; Phospholipase C gamma - metabolism; Pinocytosis; Proteins; Receptors; Receptors, Calcium-Sensing - metabolism; Science; Science (multidisciplinary); Signal Transduction

Macropinocytosis can be induced in several cell types by stimulation with growth factors. In selected cell types, notably macrophages and dendritic cells, macropinocytosis occurs constitutively, supporting the uptake of antigens for subsequent presentation. Despite their different mode of initiation...