E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses

• Published in: Nature communications Vol. 8; no. 1; pp. 14654 - 14
• Main Authors: Song, Yinjing, Lai, Lihua, Chong, Zhenlu, He, Jia, Zhang, Yuanyuan, Xue, Yue, Xie, Yiwei, Chen, Songchang, Dong, Ping, Chen, Luoquan, Chen, Zhimin, Dai, Feng, Wan, Xiaopeng, Xiao, Peng, Cao, Xuetao, Liu, Yang, Wang, Qingqing
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.03.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/109; 13/89; 14; 14/19; 38; 38/77; 631/250/256; 631/250/262; 631/326/596/2557; 64; 64/60; 692/699/255/2514; 82; 82/29; 96; 96/34; Cytoplasm; Humanities and Social Sciences; Immunology; Infections; Medicine; multidisciplinary; Neurosciences; Proteins; Respiratory syncytial virus; Science; Science (multidisciplinary); Transcription factors; Viral infections; Viruses; China

Viruses can escape from host recognition by degradation of RIG-I or interference with the RIG-I signalling to establish persistent infections. However, the mechanisms by which host cells stabilize RIG-I protein for avoiding its degradation are largely unknown. We report here that, upon virus infecti...