Spatial profiling of chromatin accessibility in mouse and human tissues

• Published in: Nature (London) Vol. 609; no. 7926; pp. 375 - 383
• Main Authors: Deng, Yanxiang, Bartosovic, Marek, Ma, Sai, Zhang, Di, Kukanja, Petra, Xiao, Yang, Su, Graham, Liu, Yang, Qin, Xiaoyu, Rosoklija, Gorazd B., Dwork, Andrew J., Mann, J. John, Xu, Mina L., Halene, Stephanie, Craft, Joseph E., Leong, Kam W., Boldrini, Maura, Castelo-Branco, Gonçalo, Fan, Rong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.09.2022; Nature Publishing Group
• Subjects: 45; 631/1647/2210/2211; 631/1647/245/2225; 631/208/177; 631/208/514/2254; 631/378/2584; Accessibility; Animals; Biomolecules; Brain; Brain - metabolism; Cell Differentiation; Cell fate; Cell Lineage; Central nervous system; Chromatin; Chromatin - genetics; Chromatin - metabolism; Chromatin Assembly and Disassembly - genetics; Chromatin Immunoprecipitation Sequencing - methods; Embryos; Epigenetics; Epigenomics; Follicles; Gene expression; Gene Expression Profiling; Gene loci; Gene mapping; Genome; Genomes; High-Throughput Nucleotide Sequencing - methods; Human tissues; Humanities and Social Sciences; Humans; Immune system; Mapping; Mice; Microfluidics; multidisciplinary; Nervous system; Next-generation sequencing; Palatine Tonsil - cytology; Palatine Tonsil - immunology; Performance evaluation; Science; Science (multidisciplinary); Spinal cord; Spleen; Tissues; Tonsil; Transcriptomics; Transposition
• ISSN: 0028-0836; 1476-4687; 1476-4687
• DOI: 10.1038/s41586-022-05094-1

Cellular function in tissue is dependent on the local environment, requiring new methods for spatial mapping of biomolecules and cells in the tissue context 1 . The emergence of spatial transcriptomics has enabled genome-scale gene expression mapping 2 – 5 , but the ability to capture spatial epigen...