Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma

• Published in: Nature communications Vol. 7; no. 1; pp. 12992 - 10
• Main Authors: Zhao, Ling-Hao, Liu, Xiao, Yan, He-Xin, Li, Wei-Yang, Zeng, Xi, Yang, Yuan, Zhao, Jie, Liu, Shi-Ping, Zhuang, Xue-Han, Lin, Chuan, Qin, Chen-Jie, Zhao, Yi, Pan, Ze-Ya, Huang, Gang, Liu, Hui, Zhang, Jin, Wang, Ruo-Yu, Yang, Yun, Wen, Wen, Lv, Gui-Shuai, Zhang, Hui-Lu, Wu, Han, Huang, Shuai, Wang, Ming-Da, Tang, Liang, Cao, Hong-Zhi, Wang, Ling, Lee, Tin-Lap, Jiang, Hui, Tan, Ye-Xiong, Yuan, Sheng-Xian, Hou, Guo-Jun, Tao, Qi-Fei, Xu, Qin-Guo, Zhang, Xiu-Qing, Wu, Meng-Chao, Xu, Xun, Wang, Jun, Yang, Huan-Ming, Zhou, Wei-Ping, Wang, Hong-Yang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.10.2016; Nature Publishing Group; Nature Portfolio
• Subjects: 631/208/69; 631/67/1858; 631/67/69; 82/51; Genes; Genomes; Genomics; Hepatitis B; Humanities and Social Sciences; Infections; Liver cancer; Liver cirrhosis; Males; multidisciplinary; Science; Science (multidisciplinary); Tumors; China

Hepatitis B virus (HBV) can integrate into the human genome, contributing to genomic instability and hepatocarcinogenesis. Here by conducting high-throughput viral integration detection and RNA sequencing, we identify 4,225 HBV integration events in tumour and adjacent non-tumour samples from 426 pa...