Alterations of the human gut microbiome in multiple sclerosis

• Published in: Nature communications Vol. 7; no. 1; p. 12015
• Main Authors: Jangi, Sushrut, Gandhi, Roopali, Cox, Laura M., Li, Ning, von Glehn, Felipe, Yan, Raymond, Patel, Bonny, Mazzola, Maria Antonietta, Liu, Shirong, Glanz, Bonnie L., Cook, Sandra, Tankou, Stephanie, Stuart, Fiona, Melo, Kirsy, Nejad, Parham, Smith, Kathleen, Topçuolu, Begüm D., Holden, James, Kivisäkk, Pia, Chitnis, Tanuja, De Jager, Philip L., Quintana, Francisco J., Gerber, Georg K., Bry, Lynn, Weiner, Howard L.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.06.2016; Nature Publishing Group; Nature Portfolio
• Subjects: 631/1647/514/1949; 631/250/249/1313/1666; 631/326/2565/2134; 692/308; Antigens; Autoimmune diseases; Disease; Humanities and Social Sciences; Immune response; Microbiota; Microorganisms; multidisciplinary; Multiple sclerosis; Science; Science (multidisciplinary); United States > US; Massachusetts

The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis (MS, n =60) and healthy controls ( n =43). Microbiome alterations in MS include...