Alterations of the human gut microbiome in multiple sclerosis
The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis (MS, n =60) and healthy controls ( n =43). Microbiome alterations in MS include...
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| Published in | Nature communications Vol. 7; no. 1; p. 12015 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
28.06.2016
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis (MS,
n
=60) and healthy controls (
n
=43). Microbiome alterations in MS include increases in
Methanobrevibacter
and
Akkermansia
and decreases in
Butyricimonas
, and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes. Patients on disease-modifying treatment show increased abundances of
Prevotella
and
Sutterella
, and decreased
Sarcina
, compared with untreated patients. MS patients of a second cohort show elevated breath methane compared with controls, consistent with our observation of increased gut
Methanobrevibacter
in MS in the first cohort. Further study is required to assess whether the observed alterations in the gut microbiome play a role in, or are a consequence of, MS pathogenesis.
The gut microbiome has been implicated in several autoimmune disorders. Here, the authors study the gut microbiome of patients with multiple sclerosis, and find correlations between altered abundance of certain gut microorganisms and changes in expression of immune defence genes. |
|---|---|
| AbstractList | The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis (MS, n=60) and healthy controls (n=43). Microbiome alterations in MS include increases in Methanobrevibacter and Akkermansia and decreases in Butyricimonas, and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes. Patients on disease-modifying treatment show increased abundances of Prevotella and Sutterella, and decreased Sarcina, compared with untreated patients. MS patients of a second cohort show elevated breath methane compared with controls, consistent with our observation of increased gut Methanobrevibacter in MS in the first cohort. Further study is required to assess whether the observed alterations in the gut microbiome play a role in, or are a consequence of, MS pathogenesis. The gut microbiome has been implicated in several autoimmune disorders. Here, the authors study the gut microbiome of patients with multiple sclerosis, and find correlations between altered abundance of certain gut microorganisms and changes in expression of immune defence genes. The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis (MS, n =60) and healthy controls ( n =43). Microbiome alterations in MS include increases in Methanobrevibacter and Akkermansia and decreases in Butyricimonas , and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes. Patients on disease-modifying treatment show increased abundances of Prevotella and Sutterella , and decreased Sarcina , compared with untreated patients. MS patients of a second cohort show elevated breath methane compared with controls, consistent with our observation of increased gut Methanobrevibacter in MS in the first cohort. Further study is required to assess whether the observed alterations in the gut microbiome play a role in, or are a consequence of, MS pathogenesis. The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis (MS, n =60) and healthy controls ( n =43). Microbiome alterations in MS include increases in Methanobrevibacter and Akkermansia and decreases in Butyricimonas , and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes. Patients on disease-modifying treatment show increased abundances of Prevotella and Sutterella , and decreased Sarcina , compared with untreated patients. MS patients of a second cohort show elevated breath methane compared with controls, consistent with our observation of increased gut Methanobrevibacter in MS in the first cohort. Further study is required to assess whether the observed alterations in the gut microbiome play a role in, or are a consequence of, MS pathogenesis. The gut microbiome has been implicated in several autoimmune disorders. Here, the authors study the gut microbiome of patients with multiple sclerosis, and find correlations between altered abundance of certain gut microorganisms and changes in expression of immune defence genes. |
| ArticleNumber | 12015 |
| Author | Liu, Shirong Melo, Kirsy Cox, Laura M. Holden, James Bry, Lynn Smith, Kathleen Jangi, Sushrut Li, Ning Topçuolu, Begüm D. Quintana, Francisco J. Gandhi, Roopali Chitnis, Tanuja Yan, Raymond Tankou, Stephanie Cook, Sandra Stuart, Fiona Kivisäkk, Pia Nejad, Parham Weiner, Howard L. Gerber, Georg K. Patel, Bonny von Glehn, Felipe Glanz, Bonnie L. Mazzola, Maria Antonietta De Jager, Philip L. |
| Author_xml | – sequence: 1 givenname: Sushrut surname: Jangi fullname: Jangi, Sushrut organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School – sequence: 2 givenname: Roopali surname: Gandhi fullname: Gandhi, Roopali organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School – sequence: 3 givenname: Laura M. surname: Cox fullname: Cox, Laura M. organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School – sequence: 4 givenname: Ning surname: Li fullname: Li, Ning organization: Department of Pathology, Center for Clinical and Translational Metagenomics, Brigham and Women's Hospital, Harvard Medical School – sequence: 5 givenname: Felipe orcidid: 0000-0002-1004-7641 surname: von Glehn fullname: von Glehn, Felipe organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School – sequence: 6 givenname: Raymond surname: Yan fullname: Yan, Raymond organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School – sequence: 7 givenname: Bonny surname: Patel fullname: Patel, Bonny organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School – sequence: 8 givenname: Maria Antonietta surname: Mazzola fullname: Mazzola, Maria Antonietta organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School – sequence: 9 givenname: Shirong surname: Liu fullname: Liu, Shirong organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School – sequence: 10 givenname: Bonnie L. surname: Glanz fullname: Glanz, Bonnie L. organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School – sequence: 11 givenname: Sandra surname: Cook fullname: Cook, Sandra organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School – sequence: 12 givenname: Stephanie surname: Tankou fullname: Tankou, Stephanie organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School – sequence: 13 givenname: Fiona surname: Stuart fullname: Stuart, Fiona organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School – sequence: 14 givenname: Kirsy surname: Melo fullname: Melo, Kirsy organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School – sequence: 15 givenname: Parham surname: Nejad fullname: Nejad, Parham organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School – sequence: 16 givenname: Kathleen surname: Smith fullname: Smith, Kathleen organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School – sequence: 17 givenname: Begüm D. surname: Topçuolu fullname: Topçuolu, Begüm D. organization: Department of Microbiology, University of Massachusetts – sequence: 18 givenname: James surname: Holden fullname: Holden, James organization: Department of Microbiology, University of Massachusetts – sequence: 19 givenname: Pia surname: Kivisäkk fullname: Kivisäkk, Pia organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School – sequence: 20 givenname: Tanuja surname: Chitnis fullname: Chitnis, Tanuja organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School – sequence: 21 givenname: Philip L. surname: De Jager fullname: De Jager, Philip L. organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School – sequence: 22 givenname: Francisco J. surname: Quintana fullname: Quintana, Francisco J. organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School – sequence: 23 givenname: Georg K. surname: Gerber fullname: Gerber, Georg K. organization: Department of Pathology, Center for Clinical and Translational Metagenomics, Brigham and Women's Hospital, Harvard Medical School – sequence: 24 givenname: Lynn surname: Bry fullname: Bry, Lynn organization: Department of Pathology, Center for Clinical and Translational Metagenomics, Brigham and Women's Hospital, Harvard Medical School – sequence: 25 givenname: Howard L. surname: Weiner fullname: Weiner, Howard L. email: hweiner@partners.org organization: Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27352007$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | 631/1647/514/1949 631/250/249/1313/1666 631/326/2565/2134 692/308 Antigens Autoimmune diseases Disease Humanities and Social Sciences Immune response Microbiota Microorganisms multidisciplinary Multiple sclerosis Science Science (multidisciplinary) |
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| Title | Alterations of the human gut microbiome in multiple sclerosis |
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