A wearable chemical–electrophysiological hybrid biosensing system for real-time health and fitness monitoring

Flexible, wearable sensing devices can yield important information about the underlying physiology of a human subject for applications in real-time health and fitness monitoring. Despite significant progress in the fabrication of flexible biosensors that naturally comply with the epidermis, most des...

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Published in	Nature communications Vol. 7; no. 1; p. 11650
Main Authors	Imani, Somayeh, Bandodkar, Amay J., Mohan, A. M. Vinu, Kumar, Rajan, Yu, Shengfei, Wang, Joseph, Mercier, Patrick P.
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 23.05.2016 Nature Publishing Group Nature Portfolio
Subjects	639/166/985 639/638/11/511 639/638/11/872 96/10 Biomarkers Biomarkers - analysis Biosensing Techniques Biosensors Electrocardiography Electrodes Electrolytes Epidermis Exercise Test - instrumentation Fabrication Heart rate Human subjects Humanities and Social Sciences Humans Lactic Acid - analysis Male Monitoring, Physiologic - instrumentation multidisciplinary Physiology Science Science (multidisciplinary) Sensors Skin Sweat - chemistry La Jolla California United States > US California
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Abstract	Flexible, wearable sensing devices can yield important information about the underlying physiology of a human subject for applications in real-time health and fitness monitoring. Despite significant progress in the fabrication of flexible biosensors that naturally comply with the epidermis, most designs measure only a small number of physical or electrophysiological parameters, and neglect the rich chemical information available from biomarkers. Here, we introduce a skin-worn wearable hybrid sensing system that offers simultaneous real-time monitoring of a biochemical (lactate) and an electrophysiological signal (electrocardiogram), for more comprehensive fitness monitoring than from physical or electrophysiological sensors alone. The two sensing modalities, comprising a three-electrode amperometric lactate biosensor and a bipolar electrocardiogram sensor, are co-fabricated on a flexible substrate and mounted on the skin. Human experiments reveal that physiochemistry and electrophysiology can be measured simultaneously with negligible cross-talk, enabling a new class of hybrid sensing devices. Wearable sensors can provide continuous, convenient feedback for users but typically focus on a small number of physiological parameters. Here, the authors report a skin-worn sensing system that combines a biosensor for lactate detection with an electrocardiogram in one patch, with applications for exercise monitoring.
AbstractList	Wearable sensors can provide continuous, convenient feedback for users but typically focus on a small number of physiological parameters. Here, the authors report a skin-worn sensing system that combines a biosensor for lactate detection with an electrocardiogram in one patch, with applications for exercise monitoring. Flexible, wearable sensing devices can yield important information about the underlying physiology of a human subject for applications in real-time health and fitness monitoring. Despite significant progress in the fabrication of flexible biosensors that naturally comply with the epidermis, most designs measure only a small number of physical or electrophysiological parameters, and neglect the rich chemical information available from biomarkers. Here, we introduce a skin-worn wearable hybrid sensing system that offers simultaneous real-time monitoring of a biochemical (lactate) and an electrophysiological signal (electrocardiogram), for more comprehensive fitness monitoring than from physical or electrophysiological sensors alone. The two sensing modalities, comprising a three-electrode amperometric lactate biosensor and a bipolar electrocardiogram sensor, are co-fabricated on a flexible substrate and mounted on the skin. Human experiments reveal that physiochemistry and electrophysiology can be measured simultaneously with negligible cross-talk, enabling a new class of hybrid sensing devices. Flexible, wearable sensing devices can yield important information about the underlying physiology of a human subject for applications in real-time health and fitness monitoring. Despite significant progress in the fabrication of flexible biosensors that naturally comply with the epidermis, most designs measure only a small number of physical or electrophysiological parameters, and neglect the rich chemical information available from biomarkers. Here, we introduce a skin-worn wearable hybrid sensing system that offers simultaneous real-time monitoring of a biochemical (lactate) and an electrophysiological signal (electrocardiogram), for more comprehensive fitness monitoring than from physical or electrophysiological sensors alone. The two sensing modalities, comprising a three-electrode amperometric lactate biosensor and a bipolar electrocardiogram sensor, are co-fabricated on a flexible substrate and mounted on the skin. Human experiments reveal that physiochemistry and electrophysiology can be measured simultaneously with negligible cross-talk, enabling a new class of hybrid sensing devices. Wearable sensors can provide continuous, convenient feedback for users but typically focus on a small number of physiological parameters. Here, the authors report a skin-worn sensing system that combines a biosensor for lactate detection with an electrocardiogram in one patch, with applications for exercise monitoring.
ArticleNumber	11650
Author	Imani, Somayeh Yu, Shengfei Bandodkar, Amay J. Wang, Joseph Kumar, Rajan Mohan, A. M. Vinu Mercier, Patrick P.
Author_xml	– sequence: 1 givenname: Somayeh surname: Imani fullname: Imani, Somayeh organization: Department of Electrical and Computer Engineering, University of California, San Diego – sequence: 2 givenname: Amay J. surname: Bandodkar fullname: Bandodkar, Amay J. organization: Department of Nanoengineering, University of California, San Diego – sequence: 3 givenname: A. M. Vinu surname: Mohan fullname: Mohan, A. M. Vinu organization: Department of Nanoengineering, University of California, San Diego – sequence: 4 givenname: Rajan surname: Kumar fullname: Kumar, Rajan organization: Department of Nanoengineering, University of California, San Diego – sequence: 5 givenname: Shengfei surname: Yu fullname: Yu, Shengfei organization: Department of Electrical and Computer Engineering, University of California, San Diego – sequence: 6 givenname: Joseph surname: Wang fullname: Wang, Joseph email: josephwang@ucsd.edu organization: Department of Nanoengineering, University of California, San Diego – sequence: 7 givenname: Patrick P. surname: Mercier fullname: Mercier, Patrick P. email: pmercier@ucsd.edu organization: Department of Electrical and Computer Engineering, University of California, San Diego
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/27212140$$D View this record in MEDLINE/PubMed
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Snippet	Flexible, wearable sensing devices can yield important information about the underlying physiology of a human subject for applications in real-time health and... Wearable sensors can provide continuous, convenient feedback for users but typically focus on a small number of physiological parameters. Here, the authors...
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SubjectTerms	639/166/985 639/638/11/511 639/638/11/872 96/10 Biomarkers Biomarkers - analysis Biosensing Techniques Biosensors Electrocardiography Electrodes Electrolytes Epidermis Exercise Test - instrumentation Fabrication Heart rate Human subjects Humanities and Social Sciences Humans Lactic Acid - analysis Male Monitoring, Physiologic - instrumentation multidisciplinary Physiology Science Science (multidisciplinary) Sensors Skin Sweat - chemistry
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Title	A wearable chemical–electrophysiological hybrid biosensing system for real-time health and fitness monitoring
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