Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 107; no. 16; pp. 7431 - 7436
• Main Authors: Takahashi, Ken, Asabe, Shinichi, Wieland, Stefan, Garaigorta, Urtzi, Gastaminza, Pablo, Isogawa, Masanori, Chisari, Francis V
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 20.04.2010; National Acad Sciences
• Series: From the Cover
• Subjects: Biological Sciences; Cell Line; Cell lines; Cells; chronic hepatitis; Coculture Techniques; Dendritic cells; Dendritic Cells - cytology; Dendritic Cells - virology; Enzyme-Linked Immunosorbent Assay; Flaviviridae; HEK293 cells; HeLa Cells; Hepacivirus; Hepacivirus - metabolism; Hepatitis; Hepatitis C; Hepatitis C virus; Hepatocytes; Hepatocytes - virology; hepatoma; Humans; Immunity, Innate; Immunology; Infections; Interferon; interferons; Interferons - metabolism; Kinetics; Liver; people; Replicon; Ribonucleic acid; RNA; RNA - metabolism; Signal Transduction; Toll-like receptor 7; Toll-Like Receptors - metabolism; transfer RNA; virion; Virus Replication; Viruses

Hepatitis C virus (HCV), a member of the Flaviviridae family, is a single-stranded positive-sense RNA virus that infects >170 million people worldwide and causes acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Despite its ability to block the innate host response in infected...