FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1

• Published in: Nature communications Vol. 7; no. 1; p. 10953
• Main Authors: Khan, Shahid Y., Vasanth, Shivakumar, Kabir, Firoz, Gottsch, John D., Khan, Arif O., Chaerkady, Raghothama, Lee, Mei-Chong W., Leitch, Carmen C., Ma, Zhiwei, Laux, Julie, Villasmil, Rafael, Khan, Shaheen N., Riazuddin, Sheikh, Akram, Javed, Cole, Robert N., Talbot, C. Conover, Pourmand, Nader, Zaghloul, Norann A., Hejtmancik, J. Fielding, Riazuddin, S. Amer
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.04.2016; Nature Publishing Group; Nature Portfolio
• Subjects: 38/39; 631/208/2489/144; 631/337/572; 631/45/612/1981; 692/699/3161; 82/81; Animals; Autophagy; Autophagy - genetics; Chromosomes; Corneal Opacity - genetics; Corneal Opacity - metabolism; Disease; Epithelial Cells - metabolism; Epithelial Cells - pathology; Eye Abnormalities - genetics; Eye Abnormalities - metabolism; Family Health; Female; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; Gene Expression Profiling - methods; Gene Expression Regulation; Gene Knockdown Techniques; Genomes; Genotype & phenotype; HEK293 Cells; HSP40 Heat-Shock Proteins - genetics; HSP40 Heat-Shock Proteins - metabolism; Humanities and Social Sciences; Humans; Lens, Crystalline - pathology; Male; Medicine; multidisciplinary; Mutation; Pedigree; Proteins; Science; Science (multidisciplinary); Transcription factors; Whole Exome Sequencing - methods; Zebrafish - genetics; Zebrafish - metabolism; Lahore Pakistan; Pakistan; California; United States > US; Maryland; Baltimore Maryland

FOXE3 is a lens-specific transcription factor that has been associated with anterior segment ocular dysgenesis. To determine the transcriptional target(s) of FOXE3 that are indispensable for the anterior segment development, we examined the transcriptome and the proteome of cells expressing truncate...