Dose-Response Mixed Models for Repeated Measures – a New Method for Assessment of Dose-Response - Wellhagen, Gustaf J.; Hamrén, Bengt; Kjellsson, Maria C.; Åstrand, Magnus (Pharmaceutical research, 2020)
Keywords: Albumin; Albumins - metabolism; Analysis; Bias; Biochemistry; Biomarkers; Biomarkers - metabolism; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; chronic kidney disease (CKD); Chronic kidney failure; Clinical trials; Computer Simulation; Creatinine; Creatinine - metabolism; Dapagliflozin; Data Interpretation, Statistical; dose-response analysis; dose-response mixed models for repeated measures (DR-MMRM); Dose-Response Relationship, Drug; Drug development; Drug dosages; Humans; Information processing; Kidney diseases; Medical Law; Methods; Mixed models for repeated measures (MMRM); Models, Statistical; Pharmacology/Toxicology; Pharmacy; Proteinuria; Renal Insufficiency, Chronic - drug therapy; Research Paper; Time Factors; Treatment Outcome; Type 2 diabetes; urinary albumin-to-creatinine ratio (UACR); Within-subjects design; dose-response analysis; Mixed models for repeated measures (MMRM); dose-response mixed models for repeated measures (DR-MMRM); chronic kidney disease (CKD); urinary albumin-to-creatinine ratio (UACR)