Carcinoma Cuniculatum of the Esophagus and Tongue: Report of Two Cases, Including TP53 Mutational Analysis

• Published in: Head & neck pathology (Totowa, N.J.) Vol. 8; no. 3; pp. 261 - 268
• Main Authors: Goh, Giap Hean, Venkateswaran, Kotamma, Leow, Pay Chin, Loh, Kwok Seng, Thamboo, Thomas Paulraj, Petersson, Fredrik
• Format: Journal Article
• Language: English
• Published: Boston Springer US 2014
• Subjects: Aged; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - pathology; Dentistry; DNA Mutational Analysis; Esophageal Neoplasms - genetics; Esophageal Neoplasms - pathology; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Oral and Maxillofacial Surgery; Original Paper; Otorhinolaryngology; Pathology; Polymerase Chain Reaction; Tongue Neoplasms - genetics; Tongue Neoplasms - pathology; Tumor Suppressor Protein p53 - analysis; Tumor Suppressor Protein p53 - genetics; Carcinoma cuniculatum; Verrucous carcinoma; Tongue; Mutation analysis; Esophagus
• ISSN: 1936-055X; 1936-0568
• DOI: 10.1007/s12105-014-0522-z

Carcinoma cuniculatum (CC) is a rare variant of extremely well differentiated squamous cell carcinoma. We present the clinicopathological features of two cases of CC; one lingual and one esophageal case with a molecular genetic study regarding the TP53 gene mutational status. Case 1 was a 62 year old male with enlarging chronic ulcer in the tongue. Case 2 was a 77 year old male with progressive dysphagia and odynophagia. Both patients were treated surgically. Both tumors showed deeply invaginating, keratin-filled, burrowing crypts lined by very well differentiated squamous epithelium. The esophageal tumor showed varying degrees of reactive nuclear atypia largely limited to the areas with dense intratumoral infiltration of neutrophils. No mutation of TP53 was identified in the esophageal case. Cytologic atypia limited to areas of significant acute inflammation may occur in CC and should, in the absence of aggressive stromal invasion, not preclude a diagnosis of CC.