A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer

• Published in: Nature communications Vol. 16; no. 1; pp. 1077 - 18
• Main Authors: Rendo, Veronica, Schubert, Michael, Khuu, Nicholas, Suarez Peredo Rodriguez, Maria F., Whyte, Declan, Ling, Xiao, van den Brink, Anouk, Huang, Kaimeng, Swift, Michelle, He, Yizhou, Zerbib, Johanna, Smith, Ross, Raaijmakers, Jonne, Bandopadhayay, Pratiti, Guenther, Lillian M., Hwang, Justin H., Iniguez, Amanda, Moody, Susan, Seo, Ji-Heui, Stover, Elizabeth H., Garraway, Levi, Hahn, William C., Stegmaier, Kimberly, Medema, René H., Chowdhury, Dipanjan, Colomé-Tatché, Maria, Ben-David, Uri, Beroukhim, Rameen, Foijer, Floris
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.01.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 13/106; 13/2; 14/63; 38; 38/39; 45; 45/23; 45/91; 631/114/2401; 631/208/737/1505; 631/67/2329; 631/67/68; 631/67/69; 82/80; Breast cancer; Breast Neoplasms - genetics; Cancer; Cell Line, Tumor; Cell survival; Copy number; DNA Copy Number Variations; DNA Damage; Dosage compensation; Female; Gene Amplification; Gene Dosage; Gene Expression Regulation, Neoplastic; Genes; Humanities and Social Sciences; Humans; Lung cancer; Lung Neoplasms - genetics; multidisciplinary; Neoplasms - genetics; Oncogenes; Radiation damage; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Science; Science (multidisciplinary); Therapeutic applications; Toxicity; Tumor cell lines; Tumors

While the effect of amplification-induced oncogene expression in cancer is known, the impact of copy-number gains on “bystander” genes is less understood. We create a comprehensive map of dosage compensation in cancer by integrating expression and copy number profiles from over 8000 tumors in The Ca...