Drosophila FIT is a protein-specific satiety hormone essential for feeding control

• Published in: Nature communications Vol. 8; no. 1; p. 14161
• Main Authors: Sun, Jinghan, Liu, Chang, Bai, Xiaobing, Li, Xiaoting, Li, Jingyun, Zhang, Zhiping, Zhang, Yunpeng, Guo, Jing, Li, Yan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.01.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/109; 13/51; 13/89; 14/19; 38/39; 38/70; 38/77; 631/378/1488; 631/378/340; 64/24; Amino acids; Animals; Brain; Drosophila melanogaster - genetics; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Fat Body - metabolism; Feeding Behavior; Food; Gene Expression Regulation - physiology; Homeostasis; Humanities and Social Sciences; Insects; Insulin; Kinases; multidisciplinary; Nervous system; Nutrition; Peptides; Proteins; Satiation; Science; Science (multidisciplinary); Sucrose; Beijing China; China

Protein homeostasis is critical for health and lifespan of animals. However, the mechanisms for controlling protein feeding remain poorly understood. Here we report that in Drosophila , protein intake-induced feeding inhibition (PIFI) is specific to protein-containing food, and this effect is mediat...