Targeted proteomics identifies liquid-biopsy signatures for extracapsular prostate cancer

• Published in: Nature communications Vol. 7; no. 1; p. 11906
• Main Authors: Kim, Yunee, Jeon, Jouhyun, Mejia, Salvador, Yao, Cindy Q, Ignatchenko, Vladimir, Nyalwidhe, Julius O, Gramolini, Anthony O, Lance, Raymond S, Troyer, Dean A, Drake, Richard R, Boutros, Paul C, Semmes, O. John, Kislinger, Thomas
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.06.2016; Nature Publishing Group; Nature Portfolio
• Subjects: 631/553/117; 631/61/475; 631/67/589/466; 692/308; 82/16; 82/58; Biomarkers; Biomarkers - urine; Biopsy; Cancer research; Humanities and Social Sciences; Humans; Liquid Biopsy; Male; Mass Spectrometry; Medical prognosis; Medical research; Middle Aged; multidisciplinary; Patients; Peptides; Prostate - pathology; Prostate cancer; Prostatic Neoplasms - pathology; Prostatic Neoplasms - urine; Proteins; Proteome; Proteomics; Science; Science (multidisciplinary); Scientific imaging; Tumors; Urine; Canada; Toronto Ontario Canada; United States > US; Virginia

Biomarkers are rapidly gaining importance in personalized medicine. Although numerous molecular signatures have been developed over the past decade, there is a lack of overlap and many biomarkers fail to validate in independent patient cohorts and hence are not useful for clinical application. For t...