Poly(C)-binding proteins as transcriptional regulators of gene expression

• Published in: Biochemical and biophysical research communications Vol. 380; no. 3; pp. 431 - 436
• Main Authors: Choi, Hack Sun, Hwang, Cheol Kyu, Song, Kyu Young, Law, Ping-Yee, Wei, Li-Na, Loh, Horace H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.03.2009
• Subjects: 60 APPLIED LIFE SCIENCES; Amino Acid Sequence; Animals; DNA; DNA-binding proteins; Gene Expression Regulation; GENE REGULATION; GENES; Humans; Mice; Molecular Sequence Data; P21-activated kinase 1; Poly C - metabolism; Poly(C)-binding proteins; Promoter Regions, Genetic; PROMOTERS; Protein Conformation; Protein Processing, Post-Translational; RNA; RNA POLYMERASES; RNA-Binding Proteins - chemistry; RNA-Binding Proteins - metabolism; SIGNALS; TRANSCRIPTION; Transcription Factors - chemistry; Transcription Factors - metabolism; Transcriptional regulation; P21-activated kinase 1; Transcriptional regulation; DNA-binding proteins; Poly(C)-binding proteins

Poly(C)-binding proteins (PCBPs) are generally known as RNA-binding proteins that interact in a sequence-specific fashion with single-stranded poly(C). They can be divided into two groups: hnRNP K and PCBP1-4. These proteins are involved mainly in various posttranscriptional regulations (e.g., mRNA...