Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation - Tang, Weixin; Hu, Johnny H.; Liu, David R. (Nature communications, 2017)
Keywords: 45/41; 631/1647/1511; 631/61/201/2110; Active control; Canonical forms; Catalysis; CRISPR; CRISPR-Cas Systems; Editing; Gene Editing; Gene expression; Gene regulation; Genome editing; Genomes; HEK293 Cells; Humanities and Social Sciences; Humans; Ligands; Mammalian cells; multidisciplinary; Nuclease; Nucleic Acid Conformation; Nucleotide sequence; RNA, Catalytic - genetics; RNA, Catalytic - metabolism; RNA, Guide, CRISPR-Cas Systems - chemistry; RNA, Guide, CRISPR-Cas Systems - genetics; RNA, Guide, CRISPR-Cas Systems - metabolism; Science; Science (multidisciplinary); Transcription activation; Transcriptional Activation