Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion

• Published in: Nature communications Vol. 7; no. 1; p. 10380
• Main Authors: Yamamoto, Yusuke, Wang, Xia, Bertrand, Denis, Kern, Florian, Zhang, Ting, Duleba, Marcin, Srivastava, Supriya, Khor, Chiea Chuen, Hu, Yuanyu, Wilson, Lane H., Blaszyk, Hagen, Rolshud, Daniil, Teh, Ming, Liu, Jianjun, Howitt, Brooke E., Vincent, Matthew, Crum, Christopher P., Nagarajan, Niranjan, Ho, Khek Yu, McKeon, Frank, Xian, Wa
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.01.2016; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/100; 631/208/737; 631/532; 631/67/1504/1477; 692/699/1503/1476/1322; Animals; Barrett Esophagus - genetics; Barrett Esophagus - pathology; Cell Differentiation; Cells, Cultured; Humanities and Social Sciences; Humans; Male; Mice; multidisciplinary; Mutation - genetics; Precancerous Conditions - genetics; Precancerous Conditions - pathology; Science; Science (multidisciplinary); Stem Cells - metabolism; Stem Cells - pathology; Tumor Cells, Cultured

The precancerous lesion known as Barrett’s oesophagus can evolve to oesophageal adenocarcinoma in decades-long processes of regenerative growth. Here we report the isolation and propagation of distinct, patient-matched stem cells of Barrett’s, gastric and oesophageal epithelia that yield divergent t...