Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion

The precancerous lesion known as Barrett’s oesophagus can evolve to oesophageal adenocarcinoma in decades-long processes of regenerative growth. Here we report the isolation and propagation of distinct, patient-matched stem cells of Barrett’s, gastric and oesophageal epithelia that yield divergent t...

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Bibliographic Details
Published inNature communications Vol. 7; no. 1; p. 10380
Main Authors Yamamoto, Yusuke, Wang, Xia, Bertrand, Denis, Kern, Florian, Zhang, Ting, Duleba, Marcin, Srivastava, Supriya, Khor, Chiea Chuen, Hu, Yuanyu, Wilson, Lane H., Blaszyk, Hagen, Rolshud, Daniil, Teh, Ming, Liu, Jianjun, Howitt, Brooke E., Vincent, Matthew, Crum, Christopher P., Nagarajan, Niranjan, Ho, Khek Yu, McKeon, Frank, Xian, Wa
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 19.01.2016
Nature Publishing Group
Nature Portfolio
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