Urinary markers in the early stage of nephropathy in patients with childhood-onset type 1 diabetes

• Published in: Pediatric nephrology (Berlin, West) Vol. 31; no. 4; pp. 623 - 631
• Main Authors: Suh, Jin-Soon, Kim, Shin-Hee, Cho, Kyoung Soon, Jung, In-Ah, Cho, Won Kyoung, Jeon, Yeon Jin, Jung, Min Ho, Suh, Byoung Kyu
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2016; Springer; Springer Nature B.V
• Subjects: Adolescent; Age of Onset; Albuminuria - diagnosis; Albuminuria - etiology; Albuminuria - urine; Biomarkers - urine; Body mass index; Care and treatment; Case-Control Studies; Child; Chitinase-3-Like Protein 1 - urine; Chronic illnesses; Creatinine; Creatinine - urine; Cross-Sectional Studies; Diabetes; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - diagnosis; Diabetic nephropathies; Diabetic Nephropathies - diagnosis; Diabetic Nephropathies - etiology; Diabetic Nephropathies - urine; Diabetic nephropathy; Diagnosis; Early Diagnosis; Fatty Acid-Binding Proteins - urine; Fatty acids; Humans; Kidney diseases; Liver; Male; Medicine; Medicine & Public Health; Nephrology; Original Article; Patient outcomes; Patients; Pediatrics; Predictive Value of Tests; Proteins; Risk factors; Type 1 diabetes; Urinalysis; Urology; Young Adult; South Korea; Biomarkers; Diabetic nephropathy; Albuminuria; Children; YKL-40; Liver-type fatty acid binding protein
• DOI: 10.1007/s00467-015-3253-9
• ISSN: 0931-041X

Background The aim of this study was to evaluate the association of a urinary tubular marker, liver-type fatty acid binding protein (L-FABP) and an inflammatory marker, serum/urinary YKL-40, with albuminuria in patients with childhood-onset type 1 diabetes (T1D). Methods Twenty-nine patients with childhood-onset T1D and 32 controls were enrolled. Serum and urinary concentrations of YKL-40 and urinary concentrations of L-FABP were measured. Results The serum levels of YKL-40 were not significantly different between the control group and the patient groups. However, the levels of urinary YKL-40/creatinine (Cr) were higher in the patients, even those with normoalbuminuria than in the controls ( p  < 0.001). The levels of urinary L-FABP/Cr were not different between the control group and the patient groups. However, the level of urinary L-FABP/Cr in the microalbuminuria group was higher than that in the normoalbuminuria group ( p  = 0.03). There were no associations between the levels of urinary albumin-to-creatinine ratio and urinary L-FABP/Cr or YKL-40/Cr. However, the urinary L-FABP/Cr level was significantly correlated with the hemoglobin A1C level ( p  = 0.005) and the urinary YKL-40/Cr level ( p  = 0.043). Conclusions Urinary L-FABP/Cr and YKL-40/Cr may reflect renal injury in early stages of nephropathy in patients with childhood-onset T1D, even in the normoalbuminuric state.