Laser irradiated phenothiazines: New potential treatment for COVID-19 explored by molecular docking

• Published in: Journal of photochemistry and photobiology. B, Biology Vol. 211; p. 111997
• Main Authors: Udrea, Ana-Maria, Avram, Speranta, Nistorescu, Simona, Pascu, Mihail-Lucian, Romanitan, Mihaela Oana
• Format: Journal Article
• Language: English
• Published: Switzerland Elsevier B.V 01.10.2020; Elsevier BV
• Subjects: Affinity; Animal models; Antihistamines; Antipsychotics; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Antiviral Agents - radiation effects; Betacoronavirus - drug effects; Betacoronavirus - enzymology; Binding; bioactive properties; Biological activity; Coronavirus 3C Proteases; Coronavirus Infections - drug therapy; Coronavirus Infections - epidemiology; Coronavirus Infections - virology; Coronaviruses; COVID-19; COVID-19 Drug Treatment; COVID-19 infection; Cysteine Endopeptidases - chemistry; Host Microbial Interactions - drug effects; Humans; Irradiation; Laser beams; Laser irradiated phenothiazines; Lasers, Solid-State; markets; Molecular docking; Molecular Docking Simulation; Neodymium lasers; Pandemics; Phenothiazines; Phenothiazines - chemistry; Phenothiazines - pharmacology; Phenothiazines - radiation effects; photobiology; Photochemical Processes; photochemistry; Pneumonia, Viral - drug therapy; Pneumonia, Viral - epidemiology; Pneumonia, Viral - virology; proteinases; Psychotropic drugs; SARS-CoV-2; Semiconductor lasers; Severe acute respiratory syndrome coronavirus 2; Structure-Activity Relationship; Thioridazine; Viral diseases; Viral Nonstructural Proteins - antagonists & inhibitors; Viral Nonstructural Proteins - chemistry; Viruses; YAG lasers; COVID-19; SARS-CoV-2; Laser irradiated phenothiazines; Molecular docking

The worldwide infection with the new Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) demands urgently new potent treatment(s). In this study we predict, using molecular docking, the binding affinity of 15 phenothiazines (antihistaminic and antipsychotic drugs) when interacting with the...