Apple polyphenol extracts prevent aspirin-induced damage to the rat gastric mucosa

• Published in: British journal of nutrition Vol. 100; no. 6; pp. 1228 - 1236
• Main Authors: D'Argenio, Giuseppe, Mazzone, Giovanna, Tuccillo, Concetta, Grandone, Ilenia, Gravina, Antonietta G., Graziani, Giulia, Fogliano, Vincenzo, Romano, Marco
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.12.2008
• Subjects: adverse effects; animal models; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Inflammatory Agents, Non-Steroidal - blood; Anti-Inflammatory Agents, Non-Steroidal - toxicity; Apple polyphenols; Apples; Aspirin; Aspirin - blood; Aspirin - toxicity; Bioactive compounds; Biological and medical sciences; Biological Availability; blood; catechin; chemically induced; Cyclooxygenase 2; Cyclooxygenase 2 - metabolism; Data analysis; disease prevention; drug effects; Drug Evaluation, Preclinical; Drug Evaluation, Preclinical - methods; duodenal ulcers; Feeding. Feeding behavior; Flavonoids; Flavonoids - therapeutic use; fruit extracts; Fundamental and applied biological sciences. Psychology; Gastric Acid; Gastric Acid - secretion; Gastric injury; gastric juice; gastric mucosa; Gastric Mucosa - drug effects; Gastrointestinal tract; growth factors; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Intercellular Signaling Peptides and Proteins - metabolism; Lipid Peroxidation; Lipid Peroxidation - drug effects; Liquid chromatography; Male; messenger RNA; metabolism; methods; Molecular weight; Natural & organic foods; Natural products; Phenols; Phenols - therapeutic use; Phytotherapy; Phytotherapy - methods; Plant Extracts; Plant Extracts - therapeutic use; Polyphenols; prevention & control; Prophylaxis; protective effect; protein synthesis; Rats; Rats, Wistar; Risk factors; Rodents; secretion; Stomach; Stomach Ulcer; Stomach Ulcer - chemically induced; Stomach Ulcer - prevention & control; therapeutic use; toxicity; Transforming Growth Factor alpha; Transforming Growth Factor alpha - metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Aspirin; Apple polyphenols; Gastric injury; Stomach; Rat; Digestive system; Injury; Mucosa; Rodentia; Extract; Acetylsalicylic acid; Apple polyphenols: Aspirin: Gastric injury; Vertebrata; Polyphenol; Apple; Mammalia; Animal; Lesion

Aspirin causes gastroduodenal ulcers and complications. Food bioactive compounds could exert beneficial effects in the gastrointestinal tract. We evaluated whether apple polyphenol extract (APE) reduced aspirin-induced injury to the rat gastric mucosa. Rats were treated with APE (10− 4 m catechin eq...