Apple polyphenol extracts prevent aspirin-induced damage to the rat gastric mucosa - D'Argenio, Giuseppe; Mazzone, Giovanna; Tuccillo, Concetta; Grandone, Ilenia; Gravina, Antonietta G.; Graziani, Giulia; Fogliano, Vincenzo; Romano, Marco (British journal of nutrition, 2008)
Keywords: adverse effects; animal models; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Inflammatory Agents, Non-Steroidal - blood; Anti-Inflammatory Agents, Non-Steroidal - toxicity; Apple polyphenols; Apples; Aspirin; Aspirin - blood; Aspirin - toxicity; Bioactive compounds; Biological and medical sciences; Biological Availability; blood; catechin; chemically induced; Cyclooxygenase 2; Cyclooxygenase 2 - metabolism; Data analysis; disease prevention; drug effects; Drug Evaluation, Preclinical; Drug Evaluation, Preclinical - methods; duodenal ulcers; Feeding. Feeding behavior; Flavonoids; Flavonoids - therapeutic use; fruit extracts; Fundamental and applied biological sciences. Psychology; Gastric Acid; Gastric Acid - secretion; Gastric injury; gastric juice; gastric mucosa; Gastric Mucosa - drug effects; Gastrointestinal tract; growth factors; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Intercellular Signaling Peptides and Proteins - metabolism; Lipid Peroxidation; Lipid Peroxidation - drug effects; Liquid chromatography; Male; messenger RNA; metabolism; methods; Molecular weight; Natural & organic foods; Natural products; Phenols; Phenols - therapeutic use; Phytotherapy; Phytotherapy - methods; Plant Extracts; Plant Extracts - therapeutic use; Polyphenols; prevention & control; Prophylaxis; protective effect; protein synthesis; Rats; Rats, Wistar; Risk factors; Rodents; secretion; Stomach; Stomach Ulcer; Stomach Ulcer - chemically induced; Stomach Ulcer - prevention & control; therapeutic use; toxicity; Transforming Growth Factor alpha; Transforming Growth Factor alpha - metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Aspirin; Apple polyphenols; Gastric injury; Stomach; Rat; Digestive system; Injury; Mucosa; Rodentia; Extract; Acetylsalicylic acid; Apple polyphenols: Aspirin: Gastric injury; Vertebrata; Polyphenol; Apple; Mammalia; Animal; Lesion