Exosome-Derived MiRNAs as Biomarkers of the Development and Progression of Intracranial Aneurysms

• Published in: Journal of Atherosclerosis and Thrombosis Vol. 27; no. 6; pp. 545 - 610
• Main Authors: Qin, Chao, Zhong, Song-xin, Liao, Bao, Zhou, Feng-kun, Qin, Yan-sheng, Zhou, Meng-xiao, Li, Ping-ping, Luo, Xiu-mei, Zhou, Yuan-fang
• Format: Journal Article
• Language: English
• Published: Japan Japan Atherosclerosis Society 01.06.2020
• Subjects: Aneurysm, Ruptured - complications; Aneurysm, Ruptured - diagnosis; Aneurysm, Ruptured - epidemiology; Aneurysm, Ruptured - genetics; China - epidemiology; Disease Progression; Exosome; Exosomes - genetics; Female; Gene Expression Profiling - methods; Gene Expression Regulation; Genetic Markers; High-Throughput Nucleotide Sequencing - methods; Humans; Intracranial aneurysm; Intracranial Aneurysm - diagnosis; Intracranial Aneurysm - epidemiology; Intracranial Aneurysm - genetics; Male; MicroRNA; MicroRNAs - genetics; Middle Aged; MiR-145-5p; MiR-29a-3p; Original; Reproducibility of Results; Subarachnoid hemorrhage; Subarachnoid Hemorrhage - diagnosis; Subarachnoid Hemorrhage - epidemiology; China; MiR-145-5p; MicroRNA; MiR-29a-3p; Exosome; Subarachnoid hemorrhage; Intracranial aneurysm

Aim: Exosome-derived microRNAs (miRNAs) are potential diagnostic biomarkers. However, little is known about their effectiveness as diagnostic biomarkers of intracranial aneurysms (IAs). This study aimed to explore miRNA levels in plasma exosomes of patients with IA to identify potential biomarkers t...