USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response

BRCA1 regulates multiple cellular pathways that maintain genomic stability including cell cycle checkpoints, DNA repair, protein ubiquitination, chromatin remodelling, transcriptional regulation and apoptosis. Receptor-associated protein 80 (RAP80) helps recruit BRCA1 to double-strand breaks (DSBs)...

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Published inNature communications Vol. 8; no. 1; pp. 15752 - 12
Main Authors Li, Yunhui, Luo, Kuntian, Yin, Yujiao, Wu, Chenming, Deng, Min, Li, Lei, Chen, Yuping, Nowsheen, Somaira, Lou, Zhenkun, Yuan, Jian
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.06.2017
Nature Publishing Group
Nature Portfolio
Subjects
631/337/1427/2122
631/80/458/582
Animals
Ataxia Telangiectasia Mutated Proteins - metabolism
BRCA1 Protein - genetics
BRCA1 Protein - metabolism
Breast cancer
Cancer therapies
Carrier Proteins - genetics
Carrier Proteins - metabolism
Cell cycle
Cell Line, Tumor
Cisplatin - pharmacology
Deoxyribonucleic acid
DNA
DNA damage
DNA repair
DNA Repair - physiology
DNA-Binding Proteins
Drug Resistance, Neoplasm - drug effects
Drug Resistance, Neoplasm - genetics
Endopeptidases - genetics
Endopeptidases - metabolism
Female
Histone Chaperones
Humanities and Social Sciences
Humans
Medicine
Mice, Nude
multidisciplinary
Multiprotein Complexes - metabolism
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Ovarian cancer
Ovarian Neoplasms - drug therapy
Ovarian Neoplasms - genetics
Ovarian Neoplasms - pathology
Phosphorylation
Phthalazines - pharmacology
Piperazines - pharmacology
Proteins
Recruitment
Science
Science (multidisciplinary)
Signal transduction
Ubiquitination
Xenograft Model Antitumor Assays
United States > US
China
Minnesota
Online AccessGet full text
ISSN2041-1723
2041-1723
DOI10.1038/ncomms15752

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Abstract BRCA1 regulates multiple cellular pathways that maintain genomic stability including cell cycle checkpoints, DNA repair, protein ubiquitination, chromatin remodelling, transcriptional regulation and apoptosis. Receptor-associated protein 80 (RAP80) helps recruit BRCA1 to double-strand breaks (DSBs) through the scaffold protein CCDC98 (Abraxas) and facilitates DNA damage response (DDR). However, the regulation of RAP80-BRCA1 complex is still unclear. Here we report that a deubiquitinase, USP13, regulates DDR by targeting RAP80. Mechanistically, USP13 is phosphorylated by ATM following DNA damage which, in turn, facilitates its DSB localization. USP13, in turn, deubiquitinates RAP80 and promotes RAP80 recruitment and proper DDR. Depleting or inhibiting USP13 sensitizes ovarian cancer cells to cisplatin and PARP inhibitor (olaparib) while overexpression of USP13 renders ovarian cancer cells resistant to chemotherapy. Overall, we identify USP13 as a regulator of DNA repair and reveal a model in which a phosphorylation-deubiquitination axis dynamically regulates RAP80-BRCA1 complex foci formation and function. RAP80 helps to recruit BRCA1 to double-strand breaks, facilitating DNA damage responses. Here the authors report that phosphorylated USP13 deubiquitinates RAP80 after DNA damage, prompting recruitment to the break site.
AbstractList BRCA1 regulates multiple cellular pathways that maintain genomic stability including cell cycle checkpoints, DNA repair, protein ubiquitination, chromatin remodelling, transcriptional regulation and apoptosis. Receptor-associated protein 80 (RAP80) helps recruit BRCA1 to double-strand breaks (DSBs) through the scaffold protein CCDC98 (Abraxas) and facilitates DNA damage response (DDR). However, the regulation of RAP80-BRCA1 complex is still unclear. Here we report that a deubiquitinase, USP13, regulates DDR by targeting RAP80. Mechanistically, USP13 is phosphorylated by ATM following DNA damage which, in turn, facilitates its DSB localization. USP13, in turn, deubiquitinates RAP80 and promotes RAP80 recruitment and proper DDR. Depleting or inhibiting USP13 sensitizes ovarian cancer cells to cisplatin and PARP inhibitor (olaparib) while overexpression of USP13 renders ovarian cancer cells resistant to chemotherapy. Overall, we identify USP13 as a regulator of DNA repair and reveal a model in which a phosphorylation-deubiquitination axis dynamically regulates RAP80-BRCA1 complex foci formation and function.BRCA1 regulates multiple cellular pathways that maintain genomic stability including cell cycle checkpoints, DNA repair, protein ubiquitination, chromatin remodelling, transcriptional regulation and apoptosis. Receptor-associated protein 80 (RAP80) helps recruit BRCA1 to double-strand breaks (DSBs) through the scaffold protein CCDC98 (Abraxas) and facilitates DNA damage response (DDR). However, the regulation of RAP80-BRCA1 complex is still unclear. Here we report that a deubiquitinase, USP13, regulates DDR by targeting RAP80. Mechanistically, USP13 is phosphorylated by ATM following DNA damage which, in turn, facilitates its DSB localization. USP13, in turn, deubiquitinates RAP80 and promotes RAP80 recruitment and proper DDR. Depleting or inhibiting USP13 sensitizes ovarian cancer cells to cisplatin and PARP inhibitor (olaparib) while overexpression of USP13 renders ovarian cancer cells resistant to chemotherapy. Overall, we identify USP13 as a regulator of DNA repair and reveal a model in which a phosphorylation-deubiquitination axis dynamically regulates RAP80-BRCA1 complex foci formation and function.
RAP80 helps to recruit BRCA1 to double-strand breaks, facilitating DNA damage responses. Here the authors report that phosphorylated USP13 deubiquitinates RAP80 after DNA damage, prompting recruitment to the break site.
BRCA1 regulates multiple cellular pathways that maintain genomic stability including cell cycle checkpoints, DNA repair, protein ubiquitination, chromatin remodelling, transcriptional regulation and apoptosis. Receptor-associated protein 80 (RAP80) helps recruit BRCA1 to double-strand breaks (DSBs) through the scaffold protein CCDC98 (Abraxas) and facilitates DNA damage response (DDR). However, the regulation of RAP80-BRCA1 complex is still unclear. Here we report that a deubiquitinase, USP13, regulates DDR by targeting RAP80. Mechanistically, USP13 is phosphorylated by ATM following DNA damage which, in turn, facilitates its DSB localization. USP13, in turn, deubiquitinates RAP80 and promotes RAP80 recruitment and proper DDR. Depleting or inhibiting USP13 sensitizes ovarian cancer cells to cisplatin and PARP inhibitor (olaparib) while overexpression of USP13 renders ovarian cancer cells resistant to chemotherapy. Overall, we identify USP13 as a regulator of DNA repair and reveal a model in which a phosphorylation-deubiquitination axis dynamically regulates RAP80-BRCA1 complex foci formation and function.
BRCA1 regulates multiple cellular pathways that maintain genomic stability including cell cycle checkpoints, DNA repair, protein ubiquitination, chromatin remodelling, transcriptional regulation and apoptosis. Receptor-associated protein 80 (RAP80) helps recruit BRCA1 to double-strand breaks (DSBs) through the scaffold protein CCDC98 (Abraxas) and facilitates DNA damage response (DDR). However, the regulation of RAP80-BRCA1 complex is still unclear. Here we report that a deubiquitinase, USP13, regulates DDR by targeting RAP80. Mechanistically, USP13 is phosphorylated by ATM following DNA damage which, in turn, facilitates its DSB localization. USP13, in turn, deubiquitinates RAP80 and promotes RAP80 recruitment and proper DDR. Depleting or inhibiting USP13 sensitizes ovarian cancer cells to cisplatin and PARP inhibitor (olaparib) while overexpression of USP13 renders ovarian cancer cells resistant to chemotherapy. Overall, we identify USP13 as a regulator of DNA repair and reveal a model in which a phosphorylation-deubiquitination axis dynamically regulates RAP80-BRCA1 complex foci formation and function. RAP80 helps to recruit BRCA1 to double-strand breaks, facilitating DNA damage responses. Here the authors report that phosphorylated USP13 deubiquitinates RAP80 after DNA damage, prompting recruitment to the break site.
ArticleNumber 15752
Author Yuan, Jian
Nowsheen, Somaira
Deng, Min
Li, Yunhui
Wu, Chenming
Chen, Yuping
Lou, Zhenkun
Yin, Yujiao
Li, Lei
Luo, Kuntian
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  fullname: Luo, Kuntian
  organization: Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Department of Oncology, Mayo Clinic
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/28569838$$D View this record in MEDLINE/PubMed
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Snippet BRCA1 regulates multiple cellular pathways that maintain genomic stability including cell cycle checkpoints, DNA repair, protein ubiquitination, chromatin...
RAP80 helps to recruit BRCA1 to double-strand breaks, facilitating DNA damage responses. Here the authors report that phosphorylated USP13 deubiquitinates...
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SubjectTerms 631/337/1427/2122
631/80/458/582
Animals
Ataxia Telangiectasia Mutated Proteins - metabolism
BRCA1 Protein - genetics
BRCA1 Protein - metabolism
Breast cancer
Cancer therapies
Carrier Proteins - genetics
Carrier Proteins - metabolism
Cell cycle
Cell Line, Tumor
Cisplatin - pharmacology
Deoxyribonucleic acid
DNA
DNA damage
DNA repair
DNA Repair - physiology
DNA-Binding Proteins
Drug Resistance, Neoplasm - drug effects
Drug Resistance, Neoplasm - genetics
Endopeptidases - genetics
Endopeptidases - metabolism
Female
Histone Chaperones
Humanities and Social Sciences
Humans
Medicine
Mice, Nude
multidisciplinary
Multiprotein Complexes - metabolism
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Ovarian cancer
Ovarian Neoplasms - drug therapy
Ovarian Neoplasms - genetics
Ovarian Neoplasms - pathology
Phosphorylation
Phthalazines - pharmacology
Piperazines - pharmacology
Proteins
Recruitment
Science
Science (multidisciplinary)
Signal transduction
Ubiquitination
Xenograft Model Antitumor Assays
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Title USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response
URI https://link.springer.com/article/10.1038/ncomms15752
https://www.ncbi.nlm.nih.gov/pubmed/28569838
https://www.proquest.com/docview/1904250578
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https://pubmed.ncbi.nlm.nih.gov/PMC5461494
https://doaj.org/article/b9ff0e1454eb43a897db3dfb43979b21
Volume 8
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