Disruption of circadian clocks has ramifications for metabolism, brain, and behavior

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. 4; pp. 1657 - 1662
• Main Authors: Karatsoreos, Ilia N, Bhagat, Sarah, Bloss, Erik B, Morrison, John H, McEwen, Bruce S
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 25.01.2011; National Acad Sciences
• Subjects: acute effects; adverse effects; Air transportation; Aircraft; Animals; Behavior, Animal - physiology; Behavioral neuroscience; Biological Clocks - physiology; Biological Sciences; Blood Glucose - metabolism; Body temperature; Body Temperature - physiology; Brain; Brain - cytology; Brain - physiology; Circadian Clocks - physiology; Circadian rhythm; Circadian Rhythm - physiology; Circadian rhythms; CLOCK protein; cognition; Cognitive ability; cortex; Cortex (prefrontal); Emotions; Energy Metabolism - physiology; Executive function; Hormones; Housing; Human subjects; Humans; Hypothalamus; Insulin; Insulin - blood; Leptin - blood; lifestyle; Light effects; lighting; long term effects; Male; Maze Learning - physiology; Metabolism; Mice; Mice, Inbred C57BL; Motor Activity - physiology; Neurons; Neurons - physiology; Neurosciences; Obesity; Photoperiod; Physiology; plants (botany); Prefrontal Cortex - cytology; Prefrontal Cortex - physiology; Rodents; Sleep; Suprachiasmatic nucleus; T tests; Travel; weight gain; Weight Gain - physiology

Circadian (daily) rhythms are present in almost all plants and animals. In mammals, a brain clock located in the hypothalamic suprachiasmatic nucleus maintains synchrony between environmental light/dark cycles and physiology and behavior. Over the past 100 y, especially with the advent of electric l...