Imipramine Inhibits Chikungunya Virus Replication in Human Skin Fibroblasts through Interference with Intracellular Cholesterol Trafficking

• Published in: Scientific reports Vol. 7; no. 1; pp. 3145 - 12
• Main Authors: Wichit, Sineewanlaya, Hamel, Rodolphe, Bernard, Eric, Talignani, Loïc, Diop, Fodé, Ferraris, Pauline, Liegeois, Florian, Ekchariyawat, Peeraya, Luplertlop, Natthanej, Surasombatpattana, Pornapat, Thomas, Frédéric, Merits, Andres, Choumet, Valérie, Roques, Pierre, Yssel, Hans, Briant, Laurence, Missé, Dorothée
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.06.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 13/109; 13/31; 13/44; 13/51; 14; 42; 45; 631/154/555; 692/699/255/2514; 82; 82/1; 82/29; Androstenes; Androstenes - pharmacology; Biochemistry, Molecular Biology; Biological Transport; Biological Transport - drug effects; Cells, Cultured; Cellular Biology; Chikungunya virus; Chikungunya virus - drug effects; Cholesterol; Cholesterol - metabolism; Chukungunya Virus; Cytotoxicity; Dengue fever; Fibroblasts; Fibroblasts - cytology; Fibroblasts - virology; Humanities and Social Sciences; Humans; Imipramine; Imipramine - pharmacology; Intracellular; Life cycles; Life Sciences; Molecular biology; multidisciplinary; Niemann-Pick disease; Niemann-Pick Disease, Type C; Niemann-Pick Disease, Type C - pathology; Replication; Science; Science (multidisciplinary); Skin; Skin - cytology; Skin - drug effects; Skin - virology; Subcellular Processes; Vector-borne diseases; Viral infections; Virus Internalization; Virus Internalization - drug effects; Virus Replication; Virus Replication - drug effects

Chikungunya virus (CHIKV) is an emerging arbovirus of the Togaviridae family that poses a present worldwide threat to human in the absence of any licensed vaccine or antiviral treatment to control viral infection. Here, we show that compounds interfering with intracellular cholesterol transport have...