Quantitative chemical exchange saturation transfer (CEST) MRI of glioma using Image Downsampling Expedited Adaptive Least-squares (IDEAL) fitting

• Published in: Scientific reports Vol. 7; no. 1; pp. 84 - 10
• Main Authors: Zhou, Iris Yuwen, Wang, Enfeng, Cheung, Jerry S., Zhang, Xiaoan, Fulci, Giulia, Sun, Phillip Zhe
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.03.2017; Nature Portfolio
• Subjects: 101/6; 59/57; 631/1647/245/1628; 692/308/2778; Humanities and Social Sciences; multidisciplinary; Science; Science (multidisciplinary)

Chemical Exchange Saturation Transfer (CEST) MRI is sensitive to dilute metabolites with exchangeable protons, allowing tissue characterization in diseases such as acute stroke and tumor. CEST quantification using multi-pool Lorentzian fitting is challenging due to its strong dependence on image sig...