Macromolecular Crowding as a Regulator of Gene Transcription

• Published in: Biophysical journal Vol. 106; no. 8; pp. 1801 - 1810
• Main Authors: Matsuda, Hiroaki, Putzel, Gregory Garbès, Backman, Vadim, Szleifer, Igal
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.04.2014; Biophysical Society; The Biophysical Society
• Subjects: Biophysics; Cells; Computer Simulation; Deoxyribonucleic acid; DNA; DNA-Binding Proteins - metabolism; Gene expression; Gene Expression Regulation; Kinetics; Macromolecular Substances - metabolism; Models, Molecular; Molecules; Monte Carlo simulation; Proteins; Ribonucleic acid; RNA; RNA, Messenger - genetics; RNA, Messenger - metabolism; Systems Biophysics; Transcription Factors - metabolism; Transcription, Genetic

Studies of macromolecular crowding have shown its important effects on molecular transport and interactions in living cells. Less clear is the effect of crowding when its influence is incorporated into a complex network of interactions. Here, we explore the effects of crowding in the cell nucleus on...