Novel role of Rac-Mid1 signaling in medial cerebellar development

• Published in: Development (Cambridge) Vol. 144; no. 10; pp. 1863 - 1875
• Main Authors: Nakamura, Takashi, Ueyama, Takehiko, Ninoyu, Yuzuru, Sakaguchi, Hirofumi, Choijookhuu, Narantsog, Hishikawa, Yoshitaka, Kiyonari, Hiroshi, Kohta, Masaaki, Sakahara, Mizuho, de Curtis, Ivan, Kohmura, Eiji, Hisa, Yasuo, Aiba, Atsu, Saito, Naoaki
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 15.05.2017
• Subjects: Animals; Apoptosis; Axonogenesis; Cell Differentiation - genetics; Cells, Cultured; Cerebellum; Cerebellum - embryology; Cerebellum - metabolism; Cyclin-dependent kinase inhibitor p27; Dendrites; Gallbladder; Granule cells; Haploinsufficiency; HEK293 Cells; Humans; Math1 protein; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Knockout; Multiprotein Complexes - physiology; Neurogenesis - genetics; Organogenesis - genetics; Proteins - genetics; Proteins - physiology; rac GTP-Binding Proteins - genetics; rac GTP-Binding Proteins - physiology; Rac1 protein; Signal transduction; Signal Transduction - genetics; Smooth muscle; TOR Serine-Threonine Kinases - physiology; Cerebellum; Opitz G/BBB syndrome; Cerebellar granule neurons; Midline 1; Rac; mTORC1

Rac signaling impacts a relatively large number of downstream targets; however, few studies have established an association between Rac pathways and pathological conditions. In the present study, we generated mice with double knockout of and ( ) in cerebellar granule neurons (CGNs). We observed impa...