Changes in the Chondrocyte and Extracellular Matrix Proteome during Post-natal Mouse Cartilage Development

• Published in: Molecular & cellular proteomics Vol. 11; no. 1; p. M111.014159
• Main Authors: Wilson, Richard, Norris, Emma L., Brachvogel, Bent, Angelucci, Constanza, Zivkovic, Snezana, Gordon, Lavinia, Bernardo, Bianca C., Stermann, Jacek, Sekiguchi, Kiyotoshi, Gorman, Jeffrey J., Bateman, John F.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2012; The American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Cartilage - growth & development; Cartilage - metabolism; Chondrocytes - metabolism; Extracellular Matrix - metabolism; Mice; Mice, Inbred C57BL; Proteome

Skeletal growth by endochondral ossification involves tightly coordinated chondrocyte differentiation that creates reserve, proliferating, prehypertrophic, and hypertrophic cartilage zones in the growth plate. Many human skeletal disorders result from mutations in cartilage extracellular matrix (ECM...