Cytokine and chemokine multiplex analysis-based exploration for potential treatment and prognostic prediction in large-vessel vasculitis: A preliminary observational study
Large-vessel vasculitis (LVV) is subclassified into two phenotypes; Takayasu arteritis and giant cell arteritis. Although the pathogenesis of LVV is not fully established, IL-6-IL-17 axis and IL-12-IFN-γ axis play critical roles in the disease development. We aimed to clarify the association between...
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Published in | Frontiers in immunology Vol. 13; p. 1066916 |
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Main Authors | , , , , , , , , , , , |
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Language | English |
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23.11.2022
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Abstract | Large-vessel vasculitis (LVV) is subclassified into two phenotypes; Takayasu arteritis and giant cell arteritis. Although the pathogenesis of LVV is not fully established, IL-6-IL-17 axis and IL-12-IFN-γ axis play critical roles in the disease development. We aimed to clarify the association between the disease state and cytokine/chemokine levels, to assess disease course as prognosis and to predict regulators in patients with LVV using the blood profiles of multiple cytokines/chemokines. This retrospective analysis comprised 35 LVV patients whose blood were collected, and multiplex cytokine/chemokine analysis with 28 analytes was performed. The differences of cytokines/chemokines corresponding disease status, upstream regulator analysis, pathway analysis and cluster analysis were conducted using the cytokines/chemokines profile. Relapse-free survival rate was calculated with Kaplan-Meier analysis in the classified clusters. In the robust analysis, IL-4, CCL2/MCP-1, TNFSF13/APRIL, TNFSF13B/BAFF, CHI3L1 and VEGF-A levels were significantly changed after treatment. Untreated LVV patients demonstrated activation of NFκB-related molecules and these patients are potentially treated with JAK/STAT inhibitors, anti-TNF-α inhibitors and IL-6 inhibitors. Cluster analysis in active LVV patients revealed two clusters including one with high blood levels of IL-1β, IL-6, IL-17, IL-23 and CCL20/MIP-3. A subgroup of the LVV patients showed activated IL-17 signature with high relapse frequency, and JAK/TyK2 inhibitors and IFN-γ inhibitors were detected as potentially upstream inhibitors. Blood cytokine/chemokine profiles would be useful for prediction of relapse and potentially contributes to establish therapeutic strategy as precision medicine in LVV patients. |
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AbstractList | Large-vessel vasculitis (LVV) is subclassified into two phenotypes; Takayasu arteritis and giant cell arteritis. Although the pathogenesis of LVV is not fully established, IL-6−IL-17 axis and IL-12−IFN-γ axis play critical roles in the disease development. We aimed to clarify the association between the disease state and cytokine/chemokine levels, to assess disease course as prognosis and to predict regulators in patients with LVV using the blood profiles of multiple cytokines/chemokines. This retrospective analysis comprised 35 LVV patients whose blood were collected, and multiplex cytokine/chemokine analysis with 28 analytes was performed. The differences of cytokines/chemokines corresponding disease status, upstream regulator analysis, pathway analysis and cluster analysis were conducted using the cytokines/chemokines profile. Relapse-free survival rate was calculated with Kaplan-Meier analysis in the classified clusters. In the robust analysis, IL-4, CCL2/MCP-1, TNFSF13/APRIL, TNFSF13B/BAFF, CHI3L1 and VEGF-A levels were significantly changed after treatment. Untreated LVV patients demonstrated activation of NFκB-related molecules and these patients are potentially treated with JAK/STAT inhibitors, anti-TNF-α inhibitors and IL-6 inhibitors. Cluster analysis in active LVV patients revealed two clusters including one with high blood levels of IL-1β, IL-6, IL-17, IL-23 and CCL20/MIP-3. A subgroup of the LVV patients showed activated IL-17 signature with high relapse frequency, and JAK/TyK2 inhibitors and IFN-γ inhibitors were detected as potentially upstream inhibitors. Blood cytokine/chemokine profiles would be useful for prediction of relapse and potentially contributes to establish therapeutic strategy as precision medicine in LVV patients. Large-vessel vasculitis (LVV) is subclassified into two phenotypes; Takayasu arteritis and giant cell arteritis. Although the pathogenesis of LVV is not fully established, IL-6-IL-17 axis and IL-12-IFN-γ axis play critical roles in the disease development. We aimed to clarify the association between the disease state and cytokine/chemokine levels, to assess disease course as prognosis and to predict regulators in patients with LVV using the blood profiles of multiple cytokines/chemokines. This retrospective analysis comprised 35 LVV patients whose blood were collected, and multiplex cytokine/chemokine analysis with 28 analytes was performed. The differences of cytokines/chemokines corresponding disease status, upstream regulator analysis, pathway analysis and cluster analysis were conducted using the cytokines/chemokines profile. Relapse-free survival rate was calculated with Kaplan-Meier analysis in the classified clusters. In the robust analysis, IL-4, CCL2/MCP-1, TNFSF13/APRIL, TNFSF13B/BAFF, CHI3L1 and VEGF-A levels were significantly changed after treatment. Untreated LVV patients demonstrated activation of NFκB-related molecules and these patients are potentially treated with JAK/STAT inhibitors, anti-TNF-α inhibitors and IL-6 inhibitors. Cluster analysis in active LVV patients revealed two clusters including one with high blood levels of IL-1β, IL-6, IL-17, IL-23 and CCL20/MIP-3. A subgroup of the LVV patients showed activated IL-17 signature with high relapse frequency, and JAK/TyK2 inhibitors and IFN-γ inhibitors were detected as potentially upstream inhibitors. Blood cytokine/chemokine profiles would be useful for prediction of relapse and potentially contributes to establish therapeutic strategy as precision medicine in LVV patients. |
Author | Kono, Michihiro Fujieda, Yuichiro Katsuyama, Takayuki Karino, Kohei Sato, Taiki Murakami, Masaaki Kono, Michihito Ohmura, Kazumasa Atsumi, Tatsuya Kato, Masaru Abe, Nobuya Hasebe, Rie |
AuthorAffiliation | 2 Division of Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University , Sapporo , Japan 3 Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine, Okayama University , Okayama , Japan 1 Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University , Sapporo , Japan 4 Centre for Infectious Cancers, Institute for Genetic Medicine, Hokkaido University , Sapporo , Japan |
AuthorAffiliation_xml | – name: 2 Division of Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University , Sapporo , Japan – name: 4 Centre for Infectious Cancers, Institute for Genetic Medicine, Hokkaido University , Sapporo , Japan – name: 1 Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University , Sapporo , Japan – name: 3 Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine, Okayama University , Okayama , Japan |
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Copyright | Copyright © 2022 Abe, Kono, Kono, Katsuyama, Ohmura, Sato, Karino, Fujieda, Kato, Hasebe, Murakami and Atsumi. Copyright © 2022 Abe, Kono, Kono, Katsuyama, Ohmura, Sato, Karino, Fujieda, Kato, Hasebe, Murakami and Atsumi 2022 Abe, Kono, Kono, Katsuyama, Ohmura, Sato, Karino, Fujieda, Kato, Hasebe, Murakami and Atsumi |
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Keywords | cytokine giant cell arteritis chemokine Janus-kinase inhibitor large vessel vasculitis proteomics clustering Takayasu arteritis |
Language | English |
License | Copyright © 2022 Abe, Kono, Kono, Katsuyama, Ohmura, Sato, Karino, Fujieda, Kato, Hasebe, Murakami and Atsumi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 Edited by: Chris Wincup, King’s College Hospital NHS Foundation Trust, United Kingdom This article was submitted to Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders, a section of the journal Frontiers in Immunology Reviewed by: Vikas Agarwal, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGI), India; Jorge Hernan Izquierdo Loaiza, Unit of Rheumatology - Clinica de Occidente S.A., Colombia These authors have contributed equally to this work |
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References | Krämer (B15) 2014; 30 Szodoray (B10) 2007; 46 Dong (B12) 2021; 143 Sammel (B13) 2021; 24 Mason (B1) 2010; 6 Kaiser (B7) 1998; 41 Grayson (B3) 2012; 71 Hellmich (B14) 2020; 79 Maksimowicz-McKinnon (B4) 2009; 88 Weyand (B5) 2003; 349 Wagner (B20) 1996; 148 Weaver (B6) 2006; 24 James (B9) 2020; 59 Kuwabara (B16) 2020; 79 Ramesh (B21) 2014; 211 Samson (B8) 2012; 64 Zhang (B19) 2018; 137 Saadoun (B11) 2015; 67 Sanada (B17) 2022; 61 Tombetti (B2) 2019; 58 Régnier (B18) 2020; 79 |
References_xml | – volume: 59 year: 2020 ident: B9 article-title: Unique sjogren's syndrome patient subsets defined by molecular features publication-title: Rheumatology (Oxford) doi: 10.1093/rheumatology/kez335 contributor: fullname: James – volume: 67 year: 2015 ident: B11 article-title: Th1 and Th17 cytokines drive inflammation in takayasu arteritis publication-title: Arthritis Rheumatol doi: 10.1002/art.39037 contributor: fullname: Saadoun – volume: 58 year: 2019 ident: B2 article-title: Takayasu arteritis: advanced understanding is leading to new horizons publication-title: Rheumatology (Oxford) doi: 10.1093/rheumatology/key040 contributor: fullname: Tombetti – volume: 41 year: 1998 ident: B7 article-title: Platelet-derived growth factor, intimal hyperplasia, and ischemic complications in giant cell arteritis publication-title: Arthritis Rheum doi: 10.1002/1529-0131(199804)41:4<623::AID-ART9>3.0.CO;2-6 contributor: fullname: Kaiser – volume: 143 start-page: 155515 year: 2021 ident: B12 article-title: Elevated chemokines concentration is associated with disease activity in takayasu arteritis publication-title: Cytokine doi: 10.1016/j.cyto.2021.155515 contributor: fullname: Dong – volume: 148 year: 1996 ident: B20 article-title: Interferon-gamma-producing T cells in giant cell vasculitis represent a minority of tissue-infiltrating cells and are located distant from the site of pathology publication-title: Am J Pathol contributor: fullname: Wagner – volume: 6 year: 2010 ident: B1 article-title: Takayasu arteritis–advances in diagnosis and management publication-title: Nat Rev Rheumatol doi: 10.1038/nrrheum.2010.82 contributor: fullname: Mason – volume: 24 year: 2006 ident: B6 article-title: Th17: an effector CD4 T cell lineage with regulatory T cell ties publication-title: Immunity doi: 10.1016/j.immuni.2006.06.002 contributor: fullname: Weaver – volume: 349 year: 2003 ident: B5 article-title: Medium- and large-vessel vasculitis publication-title: N Engl J Med doi: 10.1056/NEJMra022694 contributor: fullname: Weyand – volume: 79 year: 2020 ident: B16 article-title: Successful remission with tofacitinib in a patient with refractory takayasu arteritis complicated by ulcerative colitis publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2019-216606 contributor: fullname: Kuwabara – volume: 71 year: 2012 ident: B3 article-title: Distribution of arterial lesions in takayasu's arteritis and giant cell arteritis publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2011-200795 contributor: fullname: Grayson – volume: 79 year: 2020 ident: B18 article-title: Targeting JAK/STAT pathway in takayasu's arteritis publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2019-216900 contributor: fullname: Régnier – volume: 64 year: 2012 ident: B8 article-title: Th1 and Th17 lymphocytes expressing CD161 are implicated in giant cell arteritis and polymyalgia rheumatica pathogenesis publication-title: Arthritis Rheum doi: 10.1002/art.34647 contributor: fullname: Samson – volume: 211 start-page: 89 year: 2014 ident: B21 article-title: Pro-inflammatory human Th17 cells selectively express p-glycoprotein and are refractory to glucocorticoids publication-title: J Exp Med doi: 10.1084/jem.20130301 contributor: fullname: Ramesh – volume: 79 start-page: 19 year: 2020 ident: B14 article-title: 2018 update of the EULAR recommendations for the management of large vessel vasculitis publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2019-215672 contributor: fullname: Hellmich – volume: 46 year: 2007 ident: B10 article-title: Circulating cytokines in Norwegian patients with psoriatic arthritis determined by a multiplex cytokine array system publication-title: Rheumatology (Oxford) doi: 10.1093/rheumatology/kel306 contributor: fullname: Szodoray – volume: 24 year: 2021 ident: B13 article-title: Limited utility of novel serological biomarkers in patients newly suspected of having giant cell arteritis publication-title: Int J Rheum Dis doi: 10.1111/1756-185X.14111 contributor: fullname: Sammel – volume: 30 year: 2014 ident: B15 article-title: Causal analysis approaches in ingenuity pathway analysis publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt703 contributor: fullname: Krämer – volume: 61 year: 2022 ident: B17 article-title: Therapeutic effectiveness of upadacitinib combined with glucocorticoid on remission induction and maintenance in giant cell arteritis publication-title: Rheumatology (Oxford) doi: 10.1093/rheumatology/keac203 contributor: fullname: Sanada – volume: 88 year: 2009 ident: B4 article-title: Takayasu arteritis and giant cell arteritis: a spectrum within the same disease publication-title: Medicine (Baltimore) doi: 10.1097/MD.0b013e3181af70c1 contributor: fullname: Maksimowicz-McKinnon – volume: 137 year: 2018 ident: B19 article-title: Inhibition of JAK-STAT signaling suppresses pathogenic immune responses in medium and Large vessel vasculitis publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.030423 contributor: fullname: Zhang |
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Snippet | Large-vessel vasculitis (LVV) is subclassified into two phenotypes; Takayasu arteritis and giant cell arteritis. Although the pathogenesis of LVV is not fully... |
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SubjectTerms | chemokine Chemokines cytokine Cytokines giant cell arteritis Immunology Interleukin-17 Interleukin-6 large vessel vasculitis Prognosis proteomics Retrospective Studies Takayasu arteritis Tumor Necrosis Factor Inhibitors Vascular Endothelial Growth Factor A |
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Title | Cytokine and chemokine multiplex analysis-based exploration for potential treatment and prognostic prediction in large-vessel vasculitis: A preliminary observational study |
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