MicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer
A major genomic alteration in prostate cancer (PCa) is frequent loss of chromosome (chr) 8p with a common region of loss of heterozygosity (LOH) at chr8p22 locus. Genomic studies implicate this locus in the initiation of clinically significant PCa and with progression to metastatic disease. However,...
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Published in | Oncogene Vol. 36; no. 19; pp. 2667 - 2679 |
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Main Authors | , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Nature Publishing Group UK
11.05.2017
Nature Publishing Group |
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Abstract | A major genomic alteration in prostate cancer (PCa) is frequent loss of chromosome (chr) 8p with a common region of loss of heterozygosity (LOH) at chr8p22 locus. Genomic studies implicate this locus in the initiation of clinically significant PCa and with progression to metastatic disease. However, the genes within this region have not been fully characterized to date. Here we demonstrate for the first time that a microRNA component of this region—miR-383—is frequently downregulated in prostate cancer, has a critical role in determining tumor-initiating potential and is involved in prostate cancer metastasis via direct regulation of CD44, a ubiquitous marker of PCa tumor-initiating cells (TICs)/stem cells. Expression analyses of miR-383 in PCa clinical tissues established that low miR-383 expression is associated with poor prognosis. Functional data suggest that miR-383 regulates PCa tumor-initiating/stem-like cells via CD44 regulation. Ectopic expression of miR-383 inhibited tumor-initiating capacity of CD44+ PCa cells. Also, ‘anti-metastatic’ effects of ectopic miR-383 expression were observed in a PCa experimental metastasis model. In view of our results, we propose that frequent loss of miR-383 at chr8p22 region leads to tumor initiation and prostate cancer metastasis. Thus, we have identified a novel finding that associates a long observed genomic alteration to PCa stemness and metastasis. Our data suggest that restoration of miR-383 expression may be an effective therapeutic modality against PCa. Importantly, we identified miR-383 as a novel PCa tissue diagnostic biomarker with a potential that outperforms that of serum PSA. |
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AbstractList | A major genomic alteration in prostate cancer (PCa) is frequent loss of chromosome (chr) 8p with a common region of loss of heterozygosity (LOH) at chr8p22 locus. Genomic studies implicate this locus in the initiation of clinically significant PCa and with progression to metastatic disease. However, the genes within this region have not been fully characterized to date. Here we demonstrate for the first time that a microRNA component of this region--miR-383--is frequently downregulated in prostate cancer, has a critical role in determining tumor-initiating potential and is involved in prostate cancer metastasis via direct regulation of CD44, a ubiquitous marker of PCa tumor-initiating cells (TICs)/stem cells. Expression analyses of miR-383 in PCa clinical tissues established that low miR-383 expression is associated with poor prognosis. Functional data suggest that miR-383 regulates PCa tumor-initiating/stem-like cells via CD44 regulation. Ectopic expression of miR-383 inhibited tumor-initiating capacity of CD44+ PCa cells. Also, 'anti-metastatic%apos; effects of ectopic miR-383 expression were observed in a PCa experimental metastasis model. In view of our results, we propose that frequent loss of miR-383 at chr8p22 region leads to tumor initiation and prostate cancer metastasis. Thus, we have identified a novel finding that associates a long observed genomic alteration to PCa stemness and metastasis. Our data suggest that restoration of miR-383 expression may be an effective therapeutic modality against PCa. Importantly, we identified miR-383 as a novel PCa tissue diagnostic biomarker with a potential that outperforms that of serum PSA. Oncogene (2017) 36, 2667-2679; doi: 10.1038/onc.2016.419; published online 28 November 2016 A major genomic alteration in prostate cancer (PCa) is frequent loss of chromosome (chr) 8p with a common region of loss of heterozygosity (LOH) at chr8p22 locus. Genomic studies implicate this locus in the initiation of clinically significant PCa and with progression to metastatic disease. However, the genes within this region have not been fully characterized to date. Here we demonstrate for the first time that a microRNA component of this region--miR-383--is frequently downregulated in prostate cancer, has a critical role in determining tumor-initiating potential and is involved in prostate cancer metastasis via direct regulation of CD44, a ubiquitous marker of PCa tumor-initiating cells (TICs)/stem cells. Expression analyses of miR-383 in PCa clinical tissues established that low miR-383 expression is associated with poor prognosis. Functional data suggest that miR-383 regulates PCa tumor-initiating/stem-like cells via CD44 regulation. Ectopic expression of miR-383 inhibited tumor-initiating capacity of CD44+ PCa cells. Also, 'anti-metastatic%apos; effects of ectopic miR-383 expression were observed in a PCa experimental metastasis model. In view of our results, we propose that frequent loss of miR-383 at chr8p22 region leads to tumor initiation and prostate cancer metastasis. Thus, we have identified a novel finding that associates a long observed genomic alteration to PCa stemness and metastasis. Our data suggest that restoration of miR-383 expression may be an effective therapeutic modality against PCa. Importantly, we identified miR-383 as a novel PCa tissue diagnostic biomarker with a potential that outperforms that of serum PSA. A major genomic alteration in prostate cancer (PCa) is frequent loss of chromosome (chr) 8p with a common region of loss of heterozygosity (LOH) at chr8p22 locus. Genomic studies implicate this locus in the initiation of clinically significant PCa and with progression to metastatic disease. However, the genes within this region have not been fully characterized to date. Here we demonstrate for the first time that a microRNA component of this region—miR-383—is frequently downregulated in prostate cancer, has a critical role in determining tumor-initiating potential and is involved in prostate cancer metastasis via direct regulation of CD44, a ubiquitous marker of PCa tumor-initiating cells (TICs)/stem cells. Expression analyses of miR-383 in PCa clinical tissues established that low miR-383 expression is associated with poor prognosis. Functional data suggest that miR-383 regulates PCa tumor-initiating/stem-like cells via CD44 regulation. Ectopic expression of miR-383 inhibited tumor-initiating capacity of CD44+ PCa cells. Also, ‘anti-metastatic’ effects of ectopic miR-383 expression were observed in a PCa experimental metastasis model. In view of our results, we propose that frequent loss of miR-383 at chr8p22 region leads to tumor initiation and prostate cancer metastasis. Thus, we have identified a novel finding that associates a long observed genomic alteration to PCa stemness and metastasis. Our data suggest that restoration of miR-383 expression may be an effective therapeutic modality against PCa. Importantly, we identified miR-383 as a novel PCa tissue diagnostic biomarker with a potential that outperforms that of serum PSA. A major genomic alteration in prostate cancer (PCa) is frequent loss of chromosome (chr) 8p with a common region of loss of heterozygosity (LOH) at chr8p22 locus. Genomic studies implicate this locus in the initiation of clinically significant PCa and with progression to metastatic disease. However, the genes within this region have not been fully characterized to date. Here we demonstrate for the first time that a microRNA component of this region –miR-383- is frequently downregulated in prostate cancer, plays a critical role in determining tumor initiating potential and is involved in prostate cancer metastasis via direct regulation of CD44, a ubiquitous marker of PCa tumor initiating cells (TICs)/ stem cells. Expression analyses of miR-383 in PCa clinical tissues established that low miR-383 expression is associated with poor prognosis. Functional data suggests that miR-383 regulates PCa tumor initiating/ stem-like cells via CD44 regulation. Ectopic expression of miR-383 inhibited tumor initiating capacity of CD44+ PCa cells . Also, ‘anti-metastatic’ effects of ectopic miR-383 expression were observed in a PCa experimental metastasis model. In view of our results, we propose that frequent loss of miR-383 at chr8p22 region leads to tumor initiation and prostate cancer metastasis. Thus, we have identified a novel finding that associates a long observed genomic alteration to PCa stemness and metastasis. Our data suggests that restoration of miR-383 expression may be an effective therapeutic modality against PCa. Importantly, we identified miR-383 as a novel PCa tissue diagnostic biomarker with a potential that outperforms that of serum PSA. A major genomic alteration in prostate cancer (PCa) is frequent loss of chromosome (chr) 8p with a common region of loss of heterozygosity (LOH) at chr8p22 locus. Genomic studies implicate this locus in the initiation of clinically signicant PCa and with progression to metastatic disease. However, the genes within this region have not been fully characterized to date. Here we demonstrate for the rst time that a microRNA component of this regionmiR-383is frequently downregulated in prostate cancer, has a critical role in determining tumor-initiating potential and is involved in prostate cancer metastasis via direct regulation of CD44, a ubiquitous marker of PCa tumor-initiating cells (TICs)/stem cells. Expression analyses of miR-383 in PCa clinical tissues established that low miR-383 expression is associated with poor prognosis. Functional data suggest that miR-383 regulates PCa tumor-initiating/stem-like cells via CD44 regulation. Ectopic expression of miR-383 inhibited tumor-initiating capacity of CD44+ PCa cells. Also, anti-metastatic effects of ectopic miR-383 expression were observed in a PCa experimental metastasis model. In view of our results, we propose that frequent loss of miR-383 at chr8p22 region leads to tumor initiation and prostate cancer metastasis. Thus, we have identied a novel nding that associates a long observed genomic alteration to PCa stemness and metastasis. Our data suggest that restoration of miR-383 expression may be an effective therapeutic modality against PCa. Importantly, we identied miR-383 as a novel PCa tissue diagnostic biomarker with a potential that outperforms that of serum PSA. |
Audience | Academic |
Author | Majid, S Yamamura, S Saini, S Sekhon, K Hsieh, C Tabatabai, Z L Calin, G A Tanaka, Y Deng, G Yang, T Dahiya, R Mitsui, Y Bucay, N Shahryari, V |
AuthorAffiliation | Department of Urology, Veterans Affairs Medical Center, San Francisco and University of California San Francisco, CA Department of Experimental Therapeutics, Non-Coding RNA Center, MD Anderson Cancer Center, University of Texas, Houston, TX |
AuthorAffiliation_xml | – name: Department of Experimental Therapeutics, Non-Coding RNA Center, MD Anderson Cancer Center, University of Texas, Houston, TX – name: Department of Urology, Veterans Affairs Medical Center, San Francisco and University of California San Francisco, CA |
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Cites_doi | 10.1158/0008-5472.CAN-07-0533 10.1055/s-2003-41607 10.1016/S0027-9684(15)30578-2 10.1371/journal.pone.0110472 10.1101/gad.1965810 10.1158/0008-5472.CAN-05-2018 10.1038/nm.2284 10.1016/j.cellsig.2015.08.005 10.1158/0008-5472.CAN-07-1297 10.1074/jbc.M113.546044 10.1158/1078-0432.CCR-09-1423 10.1038/cddis.2010.70 10.1158/0008-5472.CAN-06-1482 10.3322/caac.20066 10.1158/0008-5472.CAN-07-5878 10.1038/ng1536 10.1016/j.cellsig.2014.01.016 10.1093/carcin/bgs371 10.1126/scisignal.2004088 10.1002/jso.21806 10.1016/j.cancergencyto.2006.11.008 10.1038/nm0211-162 10.1186/1755-8166-7-25 10.1007/s13277-015-3378-2 10.1038/sj.onc.1209327 10.1158/0008-5472.CAN-07-0673 10.1002/pros.10173 10.1158/0008-5472.CAN-07-0490 10.1158/2159-8290.CD-12-0095 10.1158/0008-5472.CAN-05-0592 10.1016/j.cell.2015.10.025 10.1073/pnas.0307323101 10.1007/s13402-016-0268-6 10.1158/0008-5472.CAN-12-0540 10.1016/j.cell.2009.01.002 10.1016/S0092-8674(03)01018-3 10.1073/pnas.0304146101 10.1016/j.bbrc.2014.10.047 10.1016/j.canlet.2015.06.004 10.1158/1078-0432.CCR-10-2619 10.1016/S1535-6108(02)00030-2 10.1093/nar/gkm995 10.1016/j.ccr.2010.05.026 10.1002/gcc.20314 10.1002/mc.20255 10.1007/s12032-013-0557-0 |
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Copyright | Macmillan Publishers Limited, part of Springer Nature. 2017 COPYRIGHT 2017 Nature Publishing Group Copyright Nature Publishing Group May 11, 2017 Macmillan Publishers Limited, part of Springer Nature. 2017. |
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References | Patrawala, Calhoun, Schneider-Broussard, Li, Bhatia, Tang (CR7) 2006; 25 Matsuyama, Pan, Yoshihiro, Kudren, Naito, Bergerheim (CR38) 2003; 54 Lian, Tian, Liu, Zhang, Li, Deng (CR26) 2010; 1 Gao, Aksoy, Dogrusoz, Dresdner, Gross, Sumer (CR34) 2013; 6 Saini, Majid, Shahryari, Arora, Yamamura, Chang (CR42) 2012; 72 Bartel (CR24) 2009; 136 Xu, Ma, Gao, Gui, Niu, Jin (CR29) 2015; 36 Betel, Wilson, Gabow, Marks, Sander (CR35) 2008; 36 Matsuyama, Pan, Oba, Yoshihiro, Matsuda, Hagarth (CR39) 2003; 34 Cerami, Gao, Dogrusoz, Gross, Sumer, Aksoy (CR33) 2012; 2 Yin, Wang, Yao, Lu, Liang, Sun (CR48) 2014; 289 Patrawala, Calhoun-Davis, Schneider-Broussard, Tang (CR9) 2007; 67 Lapointe, Li, Higgins, van de Rijn, Bair, Montgomery (CR13) 2004; 101 Patrawala, Calhoun, Schneider-Broussard, Zhou, Claypool, Tang (CR8) 2005; 65 Xu, Zeng, Tian, Xu, Cai, Wang (CR30) 2014; 453 Bova, Carter, Bussemakers, Emi, Fujiwara, Kyprianou (CR18) 1993; 53 Li, Tang (CR3) 2011; 103 Matsuyama, Oba, Matsuda, Yoshihiro, Tsukamoto, Kinjo (CR40) 2007; 174 Saini, Majid, Yamamura, Tabatabai, Suh, Shahryari (CR52) 2011; 17 Porkka, Pfeiffer, Waltering, Vessella, Tammela, Visakorpi (CR37) 2007; 67 Liu, Kelnar, Liu, Chen, Calhoun-Davis, Li (CR41) 2011; 17 Zhao, Gu, Chang, Wu, Wang, Chen (CR31) 2014; 9 Huang, Tian, Duan, Cao, Zhang, Sun (CR28) 2014; 26 Tang, Patrawala, Calhoun, Bhatia, Choy, Schneider-Broussard (CR1) 2007; 46 Taylor, Schultz, Hieronymus, Gopalan, Xiao, Carver (CR17) 2010; 18 He, Cen, Luo, Li, Li, Liang (CR27) 2013; 30 Brooks, Wolf, Smith, Dash, Guessous (CR49) 2010; 102 Perner, Demichelis, Beroukhim, Schmidt, Mosquera, Setlur (CR15) 2006; 66 Collins, Berry, Hyde, Stower, Maitland (CR5) 2005; 65 Lieberfarb, Lin, Lechpammer, Li, Tanenbaum, Febbo (CR14) 2003; 63 Krek, Grun, Poy, Wolf, Rosenberg, Epstein (CR44) 2005; 37 Iczkowski (CR10) 2010; 3 Singh, Febbo, Ross, Jackson, Manola, Ladd (CR16) 2002; 1 Hsieh, Chang, Tsai, Ke, Lu, Lee (CR47) 2013; 34 Kagan, Stein, Babaian, Joe, Pisters, Glassman (CR20) 1995; 11 Wolf, Wender, Etzioni, Thompson, D'Amico, Volk (CR50) 2010; 60 Han, Cao, Tang, Lu, Xu, Wang (CR32) 2015; 366 Saini (CR51) 2016; 39 Abeshouse, Ahn, Akbani, Ally, Amin, Andry (CR36) 2015; 163 Shen, Abate-Shen (CR2) 2010; 24 Lu, Takahashi, Furusato, Maekawa, Ikegami, Sudo (CR21) 2006; 45 Yang, Handorean, Iczkowski (CR43) 2009; 2 Wicha (CR4) 2011; 17 Kim, Dhanasekaran, Mehra, Tomlins, Gu, Yu (CR11) 2007; 67 Calin, Sevignani, Dumitru, Hyslop, Noch, Yendamuri (CR23) 2004; 101 Piovani, Savio, Traversa, Pilotta, De Petro, Barlati (CR25) 2014; 7 Liao, Zheng, He, Zheng, Wei, Wang (CR46) 2015; 27 Lapointe, Li, Giacomini, Salari, Huang, Wang (CR12) 2007; 67 El Gammal, Bruchmann, Zustin, Isbarn, Hellwinkel, Kollermann (CR22) 2010; 16 Lewis, Shih, Jones-Rhoades, Bartel, Burge (CR45) 2003; 115 Li, Chen, Calhoun-Davis, Claypool, Tang (CR6) 2008; 68 Macoska, Trybus, Benson, Sakr, Grignon, Wojno (CR19) 1995; 55 JH Kim (BFonc2016419_CR11) 2007; 67 KA Iczkowski (BFonc2016419_CR10) 2010; 3 L Patrawala (BFonc2016419_CR9) 2007; 67 GA Calin (BFonc2016419_CR23) 2004; 101 S Han (BFonc2016419_CR32) 2015; 366 G Piovani (BFonc2016419_CR25) 2014; 7 D Betel (BFonc2016419_CR35) 2008; 36 BP Lewis (BFonc2016419_CR45) 2003; 115 DP Bartel (BFonc2016419_CR24) 2009; 136 H Matsuyama (BFonc2016419_CR39) 2003; 34 JA Macoska (BFonc2016419_CR19) 1995; 55 KP Porkka (BFonc2016419_CR37) 2007; 67 J Gao (BFonc2016419_CR34) 2013; 6 AM Wolf (BFonc2016419_CR50) 2010; 60 W Lu (BFonc2016419_CR21) 2006; 45 E Cerami (BFonc2016419_CR33) 2012; 2 AT El Gammal (BFonc2016419_CR22) 2010; 16 ME Lieberfarb (BFonc2016419_CR14) 2003; 63 J Kagan (BFonc2016419_CR20) 1995; 11 J Lapointe (BFonc2016419_CR12) 2007; 67 S Saini (BFonc2016419_CR42) 2012; 72 J Lapointe (BFonc2016419_CR13) 2004; 101 DD Brooks (BFonc2016419_CR49) 2010; 102 GS Bova (BFonc2016419_CR18) 1993; 53 L Patrawala (BFonc2016419_CR8) 2005; 65 L Zhao (BFonc2016419_CR31) 2014; 9 MM Shen (BFonc2016419_CR2) 2010; 24 S Saini (BFonc2016419_CR52) 2011; 17 AT Collins (BFonc2016419_CR5) 2005; 65 C Liu (BFonc2016419_CR41) 2011; 17 H Matsuyama (BFonc2016419_CR40) 2007; 174 H Li (BFonc2016419_CR3) 2011; 103 Z Xu (BFonc2016419_CR30) 2014; 453 S Perner (BFonc2016419_CR15) 2006; 66 DG Tang (BFonc2016419_CR1) 2007; 46 D Singh (BFonc2016419_CR16) 2002; 1 J Lian (BFonc2016419_CR26) 2010; 1 K Yang (BFonc2016419_CR43) 2009; 2 XH Liao (BFonc2016419_CR46) 2015; 27 Z He (BFonc2016419_CR27) 2013; 30 H Li (BFonc2016419_CR6) 2008; 68 H Huang (BFonc2016419_CR28) 2014; 26 S Saini (BFonc2016419_CR51) 2016; 39 H Matsuyama (BFonc2016419_CR38) 2003; 54 A Abeshouse (BFonc2016419_CR36) 2015; 163 A Krek (BFonc2016419_CR44) 2005; 37 BS Taylor (BFonc2016419_CR17) 2010; 18 IS Hsieh (BFonc2016419_CR47) 2013; 34 D Xu (BFonc2016419_CR29) 2015; 36 MS Wicha (BFonc2016419_CR4) 2011; 17 L Patrawala (BFonc2016419_CR7) 2006; 25 M Yin (BFonc2016419_CR48) 2014; 289 |
References_xml | – volume: 67 start-page: 6130 year: 2007 end-page: 6135 ident: CR37 article-title: MicroRNA expression profiling in prostate cancer publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-0533 contributor: fullname: Visakorpi – volume: 34 start-page: 247 year: 2003 end-page: 249 ident: CR39 article-title: The role of chromosome 8p22 deletion for predicting disease progression and pathological staging in prostate cancer publication-title: Aktuelle Urol doi: 10.1055/s-2003-41607 contributor: fullname: Hagarth – volume: 102 start-page: 423 year: 2010 end-page: 429 ident: CR49 article-title: Prostate cancer screening 2010: updated recommendations from the American Cancer Society publication-title: J Natl Med Assoc doi: 10.1016/S0027-9684(15)30578-2 contributor: fullname: Guessous – volume: 2 start-page: 361 year: 2009 end-page: 369 ident: CR43 article-title: MicroRNAs 373 and 520c are downregulated in prostate cancer, suppress CD44 translation and enhance invasion of prostate cancer cells publication-title: Int J Clin Exp Pathol contributor: fullname: Iczkowski – volume: 9 start-page: e110472 year: 2014 ident: CR31 article-title: MicroRNA-383 regulates the apoptosis of tumor cells through targeting Gadd45g publication-title: PLoS ONE doi: 10.1371/journal.pone.0110472 contributor: fullname: Chen – volume: 24 start-page: 1967 year: 2010 end-page: 2000 ident: CR2 article-title: Molecular genetics of prostate cancer: new prospects for old challenges publication-title: Genes Dev doi: 10.1101/gad.1965810 contributor: fullname: Abate-Shen – volume: 65 start-page: 10946 year: 2005 end-page: 10951 ident: CR5 article-title: Prospective identification of tumorigenic prostate cancer stem cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-05-2018 contributor: fullname: Maitland – volume: 17 start-page: 211 year: 2011 end-page: 215 ident: CR41 article-title: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44 publication-title: Nat Med doi: 10.1038/nm.2284 contributor: fullname: Li – volume: 27 start-page: 2285 year: 2015 end-page: 2295 ident: CR46 article-title: STAT3 regulated ATR via microRNA-383 to control DNA damage to affect apoptosis in A431 cells publication-title: Cell Signal doi: 10.1016/j.cellsig.2015.08.005 contributor: fullname: Wang – volume: 67 start-page: 8229 year: 2007 end-page: 8239 ident: CR11 article-title: Integrative analysis of genomic aberrations associated with prostate cancer progression publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-1297 contributor: fullname: Yu – volume: 289 start-page: 18239 year: 2014 end-page: 18257 ident: CR48 article-title: Transactivation of micrornA-320 by microRNA-383 regulates granulosa cell functions by targeting E2F1 and SF-1 proteins publication-title: J Biol Chem doi: 10.1074/jbc.M113.546044 contributor: fullname: Sun – volume: 16 start-page: 56 year: 2010 end-page: 64 ident: CR22 article-title: Chromosome 8p deletions and 8q gains are associated with tumor progression and poor prognosis in prostate cancer publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-09-1423 contributor: fullname: Kollermann – volume: 1 start-page: e94 year: 2010 ident: CR26 article-title: Downregulation of microRNA-383 is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation by targeting IRF1 publication-title: Cell Death Dis doi: 10.1038/cddis.2010.70 contributor: fullname: Deng – volume: 66 start-page: 8337 year: 2006 end-page: 8341 ident: CR15 article-title: TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-06-1482 contributor: fullname: Setlur – volume: 60 start-page: 70 year: 2010 end-page: 98 ident: CR50 article-title: American Cancer Society guideline for the early detection of prostate cancer: update 2010 publication-title: CA Cancer J Clin doi: 10.3322/caac.20066 contributor: fullname: Volk – volume: 68 start-page: 1820 year: 2008 end-page: 1825 ident: CR6 article-title: PC3 human prostate carcinoma cell holoclones contain self-renewing tumor-initiating cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-5878 contributor: fullname: Tang – volume: 37 start-page: 495 year: 2005 end-page: 500 ident: CR44 article-title: Combinatorial microRNA target predictions publication-title: Nat Genet doi: 10.1038/ng1536 contributor: fullname: Epstein – volume: 26 start-page: 903 year: 2014 end-page: 911 ident: CR28 article-title: microRNA-383 impairs phosphorylation of H2AX by targeting PNUTS and inducing cell cycle arrest in testicular embryonal carcinoma cells publication-title: Cell Signal doi: 10.1016/j.cellsig.2014.01.016 contributor: fullname: Sun – volume: 34 start-page: 530 year: 2013 end-page: 538 ident: CR47 article-title: MicroRNA-320 suppresses the stem cell-like characteristics of prostate cancer cells by downregulating the Wnt/beta-catenin signaling pathway publication-title: Carcinogenesis doi: 10.1093/carcin/bgs371 contributor: fullname: Lee – volume: 6 start-page: pl1 year: 2013 ident: CR34 article-title: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal publication-title: Sci Signal doi: 10.1126/scisignal.2004088 contributor: fullname: Sumer – volume: 103 start-page: 558 year: 2011 end-page: 562 ident: CR3 article-title: Prostate cancer stem cells and their potential roles in metastasis publication-title: J Surg Oncol doi: 10.1002/jso.21806 contributor: fullname: Tang – volume: 174 start-page: 24 year: 2007 end-page: 34 ident: CR40 article-title: Haploinsufficiency of 8p22 may influence cancer-specific survival in prostate cancer publication-title: Cancer Genet Cytogenet doi: 10.1016/j.cancergencyto.2006.11.008 contributor: fullname: Kinjo – volume: 17 start-page: 162 year: 2011 end-page: 164 ident: CR4 article-title: Stemming a tumor with a little miR publication-title: Nat Med doi: 10.1038/nm0211-162 contributor: fullname: Wicha – volume: 63 start-page: 4781 year: 2003 end-page: 4785 ident: CR14 article-title: Genome-wide loss of heterozygosity analysis from laser capture microdissected prostate cancer using single nucleotide polymorphic allele (SNP) arrays and a novel bioinformatics platform dChipSNP publication-title: Cancer Res contributor: fullname: Febbo – volume: 7 start-page: 25 year: 2014 ident: CR25 article-title: De novo 1 Mb interstitial deletion of 8p22 in a patient with slight mental retardation and speech delay publication-title: Mol Cytogenet doi: 10.1186/1755-8166-7-25 contributor: fullname: Barlati – volume: 36 start-page: 7743 year: 2015 end-page: 7753 ident: CR29 article-title: MicroRNA-383 expression regulates proliferation, migration, invasion, and apoptosis in human glioma cells publication-title: Tumour Biol doi: 10.1007/s13277-015-3378-2 contributor: fullname: Jin – volume: 3 start-page: 1 year: 2010 end-page: 7 ident: CR10 article-title: Cell adhesion molecule CD44: its functional roles in prostate cancer publication-title: Am J Transl Res contributor: fullname: Iczkowski – volume: 25 start-page: 1696 year: 2006 end-page: 1708 ident: CR7 article-title: Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells publication-title: Oncogene doi: 10.1038/sj.onc.1209327 contributor: fullname: Tang – volume: 67 start-page: 8504 year: 2007 end-page: 8510 ident: CR12 article-title: Genomic profiling reveals alternative genetic pathways of prostate tumorigenesis publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-0673 contributor: fullname: Wang – volume: 54 start-page: 103 year: 2003 end-page: 111 ident: CR38 article-title: Clinical significance of chromosome 8p, 10q, and 16q deletions in prostate cancer publication-title: Prostate doi: 10.1002/pros.10173 contributor: fullname: Bergerheim – volume: 67 start-page: 6796 year: 2007 end-page: 6805 ident: CR9 article-title: Hierarchical organization of prostate cancer cells in xenograft tumors: the CD44+alpha2beta1+ cell population is enriched in tumor-initiating cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-0490 contributor: fullname: Tang – volume: 2 start-page: 401 year: 2012 end-page: 404 ident: CR33 article-title: The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data publication-title: Cancer Discov doi: 10.1158/2159-8290.CD-12-0095 contributor: fullname: Aksoy – volume: 65 start-page: 6207 year: 2005 end-page: 6219 ident: CR8 article-title: Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-05-0592 contributor: fullname: Tang – volume: 163 start-page: 1011 year: 2015 end-page: 1025 ident: CR36 article-title: The molecular taxonomy of primary prostate cancer publication-title: Cell doi: 10.1016/j.cell.2015.10.025 contributor: fullname: Andry – volume: 101 start-page: 2999 year: 2004 end-page: 3004 ident: CR23 article-title: Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0307323101 contributor: fullname: Yendamuri – volume: 39 start-page: 97 year: 2016 end-page: 106 ident: CR51 article-title: PSA and beyond: alternative prostate cancer biomarkers publication-title: Cell Oncol (Dordr) doi: 10.1007/s13402-016-0268-6 contributor: fullname: Saini – volume: 72 start-page: 3618 year: 2012 end-page: 3630 ident: CR42 article-title: miRNA-708 control of CD44(+) prostate cancer-initiating cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-12-0540 contributor: fullname: Chang – volume: 136 start-page: 215 year: 2009 end-page: 233 ident: CR24 article-title: MicroRNAs: target recognition and regulatory functions publication-title: Cell doi: 10.1016/j.cell.2009.01.002 contributor: fullname: Bartel – volume: 55 start-page: 5390 year: 1995 end-page: 5395 ident: CR19 article-title: Evidence for three tumor suppressor gene loci on chromosome 8p in human prostate cancer publication-title: Cancer Res contributor: fullname: Wojno – volume: 115 start-page: 787 year: 2003 end-page: 798 ident: CR45 article-title: Prediction of mammalian microRNA targets publication-title: Cell doi: 10.1016/S0092-8674(03)01018-3 contributor: fullname: Burge – volume: 53 start-page: 3869 year: 1993 end-page: 3873 ident: CR18 article-title: Homozygous deletion and frequent allelic loss of chromosome 8p22 loci in human prostate cancer publication-title: Cancer Res contributor: fullname: Kyprianou – volume: 101 start-page: 811 year: 2004 end-page: 816 ident: CR13 article-title: Gene expression profiling identifies clinically relevant subtypes of prostate cancer publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0304146101 contributor: fullname: Montgomery – volume: 453 start-page: 833 year: 2014 end-page: 838 ident: CR30 article-title: MicroRNA-383 inhibits anchorage-independent growth and induces cell cycle arrest of glioma cells by targeting CCND1 publication-title: Biochem Biophysi Res Commun doi: 10.1016/j.bbrc.2014.10.047 contributor: fullname: Wang – volume: 366 start-page: 61 year: 2015 end-page: 70 ident: CR32 article-title: ROBO3 promotes growth and metastasis of pancreatic carcinoma publication-title: Cancer Lett doi: 10.1016/j.canlet.2015.06.004 contributor: fullname: Wang – volume: 17 start-page: 5287 year: 2011 end-page: 5298 ident: CR52 article-title: Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-10-2619 contributor: fullname: Shahryari – volume: 1 start-page: 203 year: 2002 end-page: 209 ident: CR16 article-title: Gene expression correlates of clinical prostate cancer behavior publication-title: Cancer Cell doi: 10.1016/S1535-6108(02)00030-2 contributor: fullname: Ladd – volume: 36 start-page: D149 year: 2008 end-page: D153 ident: CR35 article-title: The microRNA.org resource: targets and expression publication-title: Nucleic Acids Res doi: 10.1093/nar/gkm995 contributor: fullname: Sander – volume: 18 start-page: 11 year: 2010 end-page: 22 ident: CR17 article-title: Integrative genomic profiling of human prostate cancer publication-title: Cancer Cell doi: 10.1016/j.ccr.2010.05.026 contributor: fullname: Carver – volume: 45 start-page: 509 year: 2006 end-page: 515 ident: CR21 article-title: Allelotyping analysis at chromosome arm 8p of high-grade prostatic intraepithelial neoplasia and incidental, latent, and clinical prostate cancers publication-title: Genes Chromosomes Cancer doi: 10.1002/gcc.20314 contributor: fullname: Sudo – volume: 11 start-page: 2121 year: 1995 end-page: 2126 ident: CR20 article-title: Homozygous deletions at 8p22 and 8p21 in prostate cancer implicate these regions as the sites for candidate tumor suppressor genes publication-title: Oncogene contributor: fullname: Glassman – volume: 46 start-page: 1 year: 2007 end-page: 14 ident: CR1 article-title: Prostate cancer stem/progenitor cells: identification, characterization, and implications publication-title: Mol Carcinog doi: 10.1002/mc.20255 contributor: fullname: Schneider-Broussard – volume: 30 start-page: 557 year: 2013 ident: CR27 article-title: Downregulation of miR-383 promotes glioma cell invasion by targeting insulin-like growth factor 1 receptor publication-title: Med Oncol doi: 10.1007/s12032-013-0557-0 contributor: fullname: Liang – volume: 67 start-page: 6796 year: 2007 ident: BFonc2016419_CR9 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-0490 contributor: fullname: L Patrawala – volume: 17 start-page: 5287 year: 2011 ident: BFonc2016419_CR52 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-10-2619 contributor: fullname: S Saini – volume: 3 start-page: 1 year: 2010 ident: BFonc2016419_CR10 publication-title: Am J Transl Res contributor: fullname: KA Iczkowski – volume: 289 start-page: 18239 year: 2014 ident: BFonc2016419_CR48 publication-title: J Biol Chem doi: 10.1074/jbc.M113.546044 contributor: fullname: M Yin – volume: 18 start-page: 11 year: 2010 ident: BFonc2016419_CR17 publication-title: Cancer Cell doi: 10.1016/j.ccr.2010.05.026 contributor: fullname: BS Taylor – volume: 30 start-page: 557 year: 2013 ident: BFonc2016419_CR27 publication-title: Med Oncol doi: 10.1007/s12032-013-0557-0 contributor: fullname: Z He – volume: 24 start-page: 1967 year: 2010 ident: BFonc2016419_CR2 publication-title: Genes Dev doi: 10.1101/gad.1965810 contributor: fullname: MM Shen – volume: 7 start-page: 25 year: 2014 ident: BFonc2016419_CR25 publication-title: Mol Cytogenet doi: 10.1186/1755-8166-7-25 contributor: fullname: G Piovani – volume: 63 start-page: 4781 year: 2003 ident: BFonc2016419_CR14 publication-title: Cancer Res contributor: fullname: ME Lieberfarb – volume: 115 start-page: 787 year: 2003 ident: BFonc2016419_CR45 publication-title: Cell doi: 10.1016/S0092-8674(03)01018-3 contributor: fullname: BP Lewis – volume: 163 start-page: 1011 year: 2015 ident: BFonc2016419_CR36 publication-title: Cell doi: 10.1016/j.cell.2015.10.025 contributor: fullname: A Abeshouse – volume: 101 start-page: 2999 year: 2004 ident: BFonc2016419_CR23 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0307323101 contributor: fullname: GA Calin – volume: 11 start-page: 2121 year: 1995 ident: BFonc2016419_CR20 publication-title: Oncogene contributor: fullname: J Kagan – volume: 36 start-page: D149 year: 2008 ident: BFonc2016419_CR35 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkm995 contributor: fullname: D Betel – volume: 55 start-page: 5390 year: 1995 ident: BFonc2016419_CR19 publication-title: Cancer Res contributor: fullname: JA Macoska – volume: 45 start-page: 509 year: 2006 ident: BFonc2016419_CR21 publication-title: Genes Chromosomes Cancer doi: 10.1002/gcc.20314 contributor: fullname: W Lu – volume: 453 start-page: 833 year: 2014 ident: BFonc2016419_CR30 publication-title: Biochem Biophysi Res Commun doi: 10.1016/j.bbrc.2014.10.047 contributor: fullname: Z Xu – volume: 39 start-page: 97 year: 2016 ident: BFonc2016419_CR51 publication-title: Cell Oncol (Dordr) doi: 10.1007/s13402-016-0268-6 contributor: fullname: S Saini – volume: 25 start-page: 1696 year: 2006 ident: BFonc2016419_CR7 publication-title: Oncogene doi: 10.1038/sj.onc.1209327 contributor: fullname: L Patrawala – volume: 72 start-page: 3618 year: 2012 ident: BFonc2016419_CR42 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-12-0540 contributor: fullname: S Saini – volume: 65 start-page: 6207 year: 2005 ident: BFonc2016419_CR8 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-05-0592 contributor: fullname: L Patrawala – volume: 136 start-page: 215 year: 2009 ident: BFonc2016419_CR24 publication-title: Cell doi: 10.1016/j.cell.2009.01.002 contributor: fullname: DP Bartel – volume: 2 start-page: 401 year: 2012 ident: BFonc2016419_CR33 publication-title: Cancer Discov doi: 10.1158/2159-8290.CD-12-0095 contributor: fullname: E Cerami – volume: 1 start-page: e94 year: 2010 ident: BFonc2016419_CR26 publication-title: Cell Death Dis doi: 10.1038/cddis.2010.70 contributor: fullname: J Lian – volume: 366 start-page: 61 year: 2015 ident: BFonc2016419_CR32 publication-title: Cancer Lett doi: 10.1016/j.canlet.2015.06.004 contributor: fullname: S Han – volume: 34 start-page: 530 year: 2013 ident: BFonc2016419_CR47 publication-title: Carcinogenesis doi: 10.1093/carcin/bgs371 contributor: fullname: IS Hsieh – volume: 68 start-page: 1820 year: 2008 ident: BFonc2016419_CR6 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-5878 contributor: fullname: H Li – volume: 36 start-page: 7743 year: 2015 ident: BFonc2016419_CR29 publication-title: Tumour Biol doi: 10.1007/s13277-015-3378-2 contributor: fullname: D Xu – volume: 37 start-page: 495 year: 2005 ident: BFonc2016419_CR44 publication-title: Nat Genet doi: 10.1038/ng1536 contributor: fullname: A Krek – volume: 1 start-page: 203 year: 2002 ident: BFonc2016419_CR16 publication-title: Cancer Cell doi: 10.1016/S1535-6108(02)00030-2 contributor: fullname: D Singh – volume: 102 start-page: 423 year: 2010 ident: BFonc2016419_CR49 publication-title: J Natl Med Assoc doi: 10.1016/S0027-9684(15)30578-2 contributor: fullname: DD Brooks – volume: 46 start-page: 1 year: 2007 ident: BFonc2016419_CR1 publication-title: Mol Carcinog doi: 10.1002/mc.20255 contributor: fullname: DG Tang – volume: 17 start-page: 162 year: 2011 ident: BFonc2016419_CR4 publication-title: Nat Med doi: 10.1038/nm0211-162 contributor: fullname: MS Wicha – volume: 60 start-page: 70 year: 2010 ident: BFonc2016419_CR50 publication-title: CA Cancer J Clin doi: 10.3322/caac.20066 contributor: fullname: AM Wolf – volume: 6 start-page: pl1 year: 2013 ident: BFonc2016419_CR34 publication-title: Sci Signal doi: 10.1126/scisignal.2004088 contributor: fullname: J Gao – volume: 67 start-page: 8229 year: 2007 ident: BFonc2016419_CR11 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-1297 contributor: fullname: JH Kim – volume: 54 start-page: 103 year: 2003 ident: BFonc2016419_CR38 publication-title: Prostate doi: 10.1002/pros.10173 contributor: fullname: H Matsuyama – volume: 27 start-page: 2285 year: 2015 ident: BFonc2016419_CR46 publication-title: Cell Signal doi: 10.1016/j.cellsig.2015.08.005 contributor: fullname: XH Liao – volume: 16 start-page: 56 year: 2010 ident: BFonc2016419_CR22 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-09-1423 contributor: fullname: AT El Gammal – volume: 66 start-page: 8337 year: 2006 ident: BFonc2016419_CR15 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-06-1482 contributor: fullname: S Perner – volume: 2 start-page: 361 year: 2009 ident: BFonc2016419_CR43 publication-title: Int J Clin Exp Pathol contributor: fullname: K Yang – volume: 103 start-page: 558 year: 2011 ident: BFonc2016419_CR3 publication-title: J Surg Oncol doi: 10.1002/jso.21806 contributor: fullname: H Li – volume: 34 start-page: 247 year: 2003 ident: BFonc2016419_CR39 publication-title: Aktuelle Urol doi: 10.1055/s-2003-41607 contributor: fullname: H Matsuyama – volume: 174 start-page: 24 year: 2007 ident: BFonc2016419_CR40 publication-title: Cancer Genet Cytogenet doi: 10.1016/j.cancergencyto.2006.11.008 contributor: fullname: H Matsuyama – volume: 17 start-page: 211 year: 2011 ident: BFonc2016419_CR41 publication-title: Nat Med doi: 10.1038/nm.2284 contributor: fullname: C Liu – volume: 53 start-page: 3869 year: 1993 ident: BFonc2016419_CR18 publication-title: Cancer Res contributor: fullname: GS Bova – volume: 9 start-page: e110472 year: 2014 ident: BFonc2016419_CR31 publication-title: PLoS ONE doi: 10.1371/journal.pone.0110472 contributor: fullname: L Zhao – volume: 67 start-page: 8504 year: 2007 ident: BFonc2016419_CR12 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-0673 contributor: fullname: J Lapointe – volume: 101 start-page: 811 year: 2004 ident: BFonc2016419_CR13 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0304146101 contributor: fullname: J Lapointe – volume: 65 start-page: 10946 year: 2005 ident: BFonc2016419_CR5 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-05-2018 contributor: fullname: AT Collins – volume: 26 start-page: 903 year: 2014 ident: BFonc2016419_CR28 publication-title: Cell Signal doi: 10.1016/j.cellsig.2014.01.016 contributor: fullname: H Huang – volume: 67 start-page: 6130 year: 2007 ident: BFonc2016419_CR37 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-0533 contributor: fullname: KP Porkka |
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Snippet | A major genomic alteration in prostate cancer (PCa) is frequent loss of chromosome (chr) 8p with a common region of loss of heterozygosity (LOH) at chr8p22... |
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SubjectTerms | 13/106 13/109 13/31 14/5 38/77 45/90 631/67/589/466 692/53/2421 82/29 Aged Apoptosis Biomarkers, Tumor - genetics Cancer Care and treatment CD44 antigen Cell Biology Cell Proliferation - genetics Chromosome 8 Chromosome Deletion Chromosomes Chromosomes, Human, Pair 8 - genetics Development and progression Ectopic expression Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Genomics Health aspects Heterozygosity Human Genetics Humans Hyaluronan Receptors - genetics Internal Medicine Loss of heterozygosity Male Medicine Medicine & Public Health Metastases Metastasis MicroRNA MicroRNAs MicroRNAs - genetics Middle Aged miRNA Oncology original-article Prognosis Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Protein expression Stem cells Survival Analysis |
Title | MicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer |
URI | https://link.springer.com/article/10.1038/onc.2016.419 https://www.ncbi.nlm.nih.gov/pubmed/27893706 https://www.proquest.com/docview/1897402829 https://www.proquest.com/docview/2615531203 https://search.proquest.com/docview/1844608789 https://search.proquest.com/docview/1901741882 https://pubmed.ncbi.nlm.nih.gov/PMC5426972 |
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