Alterations in the gut microbiota and metabolite profiles of patients with Kashin-Beck disease, an endemic osteoarthritis in China

• Published in: Cell death & disease Vol. 12; no. 11; pp. 1015 - 12
• Main Authors: Wang, Xi, Ning, Yujie, Li, Cheng, Gong, Yi, Huang, Ruitian, Hu, Minhan, Poulet, Blandine, Xu, Ke, Zhao, Guanghui, Zhou, Rong, Lammi, Mikko J., Guo, Xiong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.10.2021; Springer Nature B.V; Nature Publishing Group
• Subjects: 631/61/212/2142; 631/61/320; 82/58; Antibodies; Biochemistry; Biodiversity; Biomedical and Life Sciences; Case-Control Studies; Cell Biology; Cell Culture; China - epidemiology; Discriminant Analysis; Endemic Diseases; Environmental factors; Fatty acids; Feces - microbiology; Gastrointestinal Microbiome - genetics; Gene Expression Profiling; Gut microbiota; Humans; Immunology; Intestinal microflora; Kashin-Beck disease; Kashin-Beck Disease - epidemiology; Kashin-Beck Disease - metabolism; Kashin-Beck Disease - microbiology; Least-Squares Analysis; Life Sciences; Lipid metabolism; Liquid chromatography; Mass spectroscopy; Metabolic networks; Metabolites; Metabolomics; Metagenomics; Microbiology; Microbiomes; Microbiota; mikrobiologi; Orthopaedics; ortopedi; Osteoarthritis; Osteoarthritis - epidemiology; Osteoarthritis - metabolism; Osteoarthritis - microbiology; reumatologi; rheumatology; Risk Assessment; RNA, Ribosomal, 16S - genetics; RNA, Ribosomal, 16S - metabolism; rRNA 16S; Species; China
• ISSN: 2041-4889; 2041-4889
• DOI: 10.1038/s41419-021-04322-2

Kashin-Beck disease (KBD) is a severe osteochondral disorder that may be driven by the interaction between genetic and environmental factors. We aimed to improve our understanding of the gut microbiota structure in KBD patients of different grades and the relationship between the gut microbiota and...