Orally administered sodium 4-phenylbutyrate suppresses the development of dextran sulfate sodium-induced colitis in mice

• Published in: Experimental and therapeutic medicine Vol. 14; no. 6; pp. 5485 - 5490
• Main Authors: Ono, Kazuhiko, Nimura, Satoshi, Hideshima, Yuko, Nabeshima, Kazuki, Nakashima, Manabu
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.12.2017; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Analysis; Colon; Cytokines; Dextrans; Disease; Drinking water; Drug therapy; Experiments; Health aspects; Immunoglobulins; inflammation; Inflammatory bowel disease; Laboratories; oral administration; Pathogenesis; Physiological aspects; Prevention; pro-inflammatory cytokines; sodium 4-phenylbutyrate; Studies; Tumor necrosis factor-TNF; Ulcerative colitis; Japan; United States > US; ulcerative colitis; oral administration; sodium 4-phenylbutyrate; inflammation; pro-inflammatory cytokines; inflammatory bowel disease

Sodium 4-phenylbutyrate (PBA) exerts therapeutic effects in a wide range of pathologies. A previous study by the present authors revealed that intraperitoneal administration of PBA suppresses the onset of dextran sulfate sodium (DSS)-induced colitis in mice. In the present study, the effects of oral...