Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure

• Published in: Circulation (New York, N.Y.) Vol. 138; no. 12; pp. 1236 - 1252
• Main Authors: Valiente-Alandi, Iñigo, Potter, Sarah J, Salvador, Ane M, Schafer, Allison E, Schips, Tobias, Carrillo-Salinas, Francisco, Gibson, Aaron M, Nieman, Michelle L, Perkins, Charles, Sargent, Michelle A, Huo, Jiuzhou, Lorenz, John N, DeFalco, Tony, Molkentin, Jeffery D, Alcaide, Pilar, Blaxall, Burns C
• Format: Journal Article
• Language: English
• Published: United States by the American College of Cardiology Foundation and the American Heart Association, Inc 18.09.2018
• Subjects: heart failure; fibroblasts; fibrosis; fibronectins; extracellular matrix

BACKGROUND:Fibronectin (FN) polymerization is necessary for collagen matrix deposition and is a key contributor to increased abundance of cardiac myofibroblasts (MFs) after cardiac injury. We hypothesized that interfering with FN polymerization or its genetic ablation in fibroblasts would attenuate...