Population pharmacokinetics of riociguat and its metabolite in patients with chronic thromboembolic pulmonary hypertension from routine clinical practice

• Published in: Pulmonary circulation Vol. 10; no. 1; pp. 1 - 11
• Main Authors: Michaličková, Danica, Jansa, Pavel, Bursová, Miroslava, Hložek, Tomáš, Čabala, Radomír, Hartinger, Jan Miroslav, Ambrož, David, Aschermann, Michael, Lindner, Jaroslav, Linhart, Aleš, Slanař, Ondřej, Krekels, Elke H.J.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2020; John Wiley & Sons, Inc; Wiley
• Subjects: Clinical medicine; Clinical trials; Creatinine; creatinine clearance; desmethylriociguat; NONMEM; Pharmacokinetics; Population; Pulmonary hypertension; Thromboembolism; total bilirubin; total bilirubin; creatinine clearance; desmethylriociguat; NONMEM

Pharmacokinetic data for riociguat in patients with chronic thromboembolic pulmonary hypertension (CTEPH) have previously been reported from randomized clinical trials, which may not fully reflect the population encountered in routine practice. The aim of the current study was to characterize the ph...