Inhibition of xenogeneic GVHD by PEN110 treatment of donor human PBMNCs

• Published in: Transfusion (Philadelphia, Pa.) Vol. 44; no. 2; pp. 282 - 285
• Main Authors: Fast, Loren D., Semple, John W., DiLeone, Gilbert, Kim, Michael, Freedman, John, Chapman, John, Purmal, Andrei
• Format: Journal Article
• Language: English
• Published: Oxford, UK and Malden, USA Blackwell Science Inc 01.02.2004
• Subjects: Animals; Antibodies, Heterophile; Disease Models, Animal; Erythrocyte Transfusion - adverse effects; Graft vs Host Disease - immunology; Graft vs Host Disease - prevention & control; Humans; Leukocytes - immunology; Mice; Mice, SCID; Polyamines - pharmacology

BACKGROUND: Development and characterization of methods for preventing transfusion‐associated GVHD have utilized in vitro studies with human WBCs and in vivo studies in animal models. The limitation of these assays is that the in vivo GVHD response of treated human WBCs has not been tested directly....