Exposure to a PBDE/OH‐BDE mixture alters juvenile zebrafish (Danio rerio) development

• Published in: Environmental toxicology and chemistry Vol. 36; no. 1; pp. 36 - 48
• Main Authors: Macaulay, Laura J., Chernick, Melissa, Chen, Albert, Hinton, David E., Bailey, Jordan M., Kullman, Seth W., Levin, Edward D., Stapleton, Heather M.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.01.2017
• Subjects: Acute toxicity; Adult; Animals; Contaminants; Danio rerio; Development; Dose-Response Relationship, Drug; Ethers; Gene Expression - drug effects; Halogenated Diphenyl Ethers - metabolism; Halogenated Diphenyl Ethers - toxicity; Hormones; Humans; Juvenile; Metabolites; Metamorphosis; Mixture; Osteogenesis - drug effects; Osteogenesis - genetics; Pigmentation; Polybrominated Biphenyls - metabolism; Polybrominated Biphenyls - toxicity; Polybrominated diphenyl ether (PBDE); Polybrominated diphenyl ethers; Swimming behavior; Thyroid; Thyroid gland; Thyroid Gland - drug effects; Thyroid Gland - metabolism; Thyroid Hormones - genetics; Thyroid Hormones - metabolism; Toxicity; Zebrafish; Zebrafish - genetics; Zebrafish - growth & development; Zebrafish - metabolism; Juvenile; Development; Zebrafish; Polybrominated diphenyl ether (PBDE); Mixture

Polybrominated diphenyl ethers (PBDEs) and their metabolites (e.g., hydroxylated BDEs [OH‐BDEs]) are contaminants frequently detected together in human tissues and are structurally similar to thyroid hormones. Thyroid hormones partially mediate metamorphic transitions between life stages in zebrafis...