Exposure to a PBDE/OH‐BDE mixture alters juvenile zebrafish (Danio rerio) development
Polybrominated diphenyl ethers (PBDEs) and their metabolites (e.g., hydroxylated BDEs [OH‐BDEs]) are contaminants frequently detected together in human tissues and are structurally similar to thyroid hormones. Thyroid hormones partially mediate metamorphic transitions between life stages in zebrafis...
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| Published in | Environmental toxicology and chemistry Vol. 36; no. 1; pp. 36 - 48 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Blackwell Publishing Ltd
01.01.2017
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Polybrominated diphenyl ethers (PBDEs) and their metabolites (e.g., hydroxylated BDEs [OH‐BDEs]) are contaminants frequently detected together in human tissues and are structurally similar to thyroid hormones. Thyroid hormones partially mediate metamorphic transitions between life stages in zebrafish, making this a critical developmental window that may be vulnerable to chemicals disrupting thyroid signaling. In the present study, zebrafish were exposed to 6‐OH‐BDE‐47 (30 nM; 15 μg/L) alone, or to a low‐dose (30 μg/L) or high‐dose (600 μg/L) mixture of PentaBDEs, 6‐OH‐BDE‐47 (0.5–6 μg/L), and 2,4,6‐tribromophenol (5–100 μg/L) during juvenile development (9–23 d postfertilization) and evaluated for developmental endpoints mediated by thyroid hormone signaling. Fish were sampled at 3 time points and examined for developmental and skeletal morphology, apical thyroid and skeletal gene markers, and modifications in swimming behavior (as adults). Exposure to the high‐dose mixture resulted in >85% mortality within 1 wk of exposure, despite being below reported acute toxicity thresholds for individual congeners. The low‐dose mixture and 6‐OH‐BDE‐47 groups exhibited reductions in body length and delayed maturation, specifically relating to swim bladder, fin, and pigmentation development. Reduced skeletal ossification was also observed in 6‐OH‐BDE‐47–treated fish. Assessment of thyroid and osteochondral gene regulatory networks demonstrated significantly increased expression of genes that regulate skeletal development and thyroid hormones. Overall, these results indicate that exposures to PBDE/OH‐BDE mixtures adversely impact zebrafish maturation during metamorphosis. Environ Toxicol Chem 2017;36:36–48. © 2016 SETAC |
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| AbstractList | Polybrominated diphenyl ethers (PBDEs) and their metabolites (e.g., hydroxylated BDEs [OH-BDEs]) are contaminants frequently detected together in human tissues and are structurally similar to thyroid hormones. Thyroid hormones partially mediate metamorphic transitions between life stages in zebrafish, making this a critical developmental window that may be vulnerable to chemicals disrupting thyroid signaling. In the present study, zebrafish were exposed to 6-OH-BDE-47 (30 nM; 15 μg/L) alone, or to a low-dose (30 μg/L) or high-dose (600 μg/L) mixture of PentaBDEs, 6-OH-BDE-47 (0.5-6 μg/L), and 2,4,6-tribromophenol (5-100 μg/L) during juvenile development (9-23 d postfertilization) and evaluated for developmental endpoints mediated by thyroid hormone signaling. Fish were sampled at 3 time points and examined for developmental and skeletal morphology, apical thyroid and skeletal gene markers, and modifications in swimming behavior (as adults). Exposure to the high-dose mixture resulted in >85% mortality within 1 wk of exposure, despite being below reported acute toxicity thresholds for individual congeners. The low-dose mixture and 6-OH-BDE-47 groups exhibited reductions in body length and delayed maturation, specifically relating to swim bladder, fin, and pigmentation development. Reduced skeletal ossification was also observed in 6-OH-BDE-47-treated fish. Assessment of thyroid and osteochondral gene regulatory networks demonstrated significantly increased expression of genes that regulate skeletal development and thyroid hormones. Overall, these results indicate that exposures to PBDE/OH-BDE mixtures adversely impact zebrafish maturation during metamorphosis. Environ Toxicol Chem 2017;36:36-48. © 2016 SETAC. Polybrominated diphenyl ethers (PBDEs) and their metabolites (e.g., hydroxylated BDEs [OH-BDEs]) are contaminants frequently detected together in human tissues and are structurally similar to thyroid hormones. Thyroid hormones partially mediate metamorphic transitions between life stages in zebrafish, making this a critical developmental window that may be vulnerable to chemicals disrupting thyroid signaling. In the present study, zebrafish were exposed to 6-OH-BDE-47 (30nM; 15µg/L) alone, or to a low-dose (30µg/L) or high-dose (600µg/L) mixture of PentaBDEs, 6-OH-BDE-47 (0.5-6µg/L), and 2,4,6-tribromophenol (5-100µg/L) during juvenile development (9-23d postfertilization) and evaluated for developmental endpoints mediated by thyroid hormone signaling. Fish were sampled at 3 time points and examined for developmental and skeletal morphology, apical thyroid and skeletal gene markers, and modifications in swimming behavior (as adults). Exposure to the high-dose mixture resulted in >85% mortality within 1wk of exposure, despite being below reported acute toxicity thresholds for individual congeners. The low-dose mixture and 6-OH-BDE-47 groups exhibited reductions in body length and delayed maturation, specifically relating to swim bladder, fin, and pigmentation development. Reduced skeletal ossification was also observed in 6-OH-BDE-47-treated fish. Assessment of thyroid and osteochondral gene regulatory networks demonstrated significantly increased expression of genes that regulate skeletal development and thyroid hormones. Overall, these results indicate that exposures to PBDE/OH-BDE mixtures adversely impact zebrafish maturation during metamorphosis. Environ Toxicol Chem 2017;36:36-48. © 2016 SETAC Abstract Polybrominated diphenyl ethers (PBDEs) and their metabolites (e.g., hydroxylated BDEs [OH‐BDEs]) are contaminants frequently detected together in human tissues and are structurally similar to thyroid hormones. Thyroid hormones partially mediate metamorphic transitions between life stages in zebrafish, making this a critical developmental window that may be vulnerable to chemicals disrupting thyroid signaling. In the present study, zebrafish were exposed to 6‐OH‐BDE‐47 (30 nM; 15 μg/L) alone, or to a low‐dose (30 μg/L) or high‐dose (600 μg/L) mixture of PentaBDEs, 6‐OH‐BDE‐47 (0.5–6 μg/L), and 2,4,6‐tribromophenol (5–100 μg/L) during juvenile development (9–23 d postfertilization) and evaluated for developmental endpoints mediated by thyroid hormone signaling. Fish were sampled at 3 time points and examined for developmental and skeletal morphology, apical thyroid and skeletal gene markers, and modifications in swimming behavior (as adults). Exposure to the high‐dose mixture resulted in >85% mortality within 1 wk of exposure, despite being below reported acute toxicity thresholds for individual congeners. The low‐dose mixture and 6‐OH‐BDE‐47 groups exhibited reductions in body length and delayed maturation, specifically relating to swim bladder, fin, and pigmentation development. Reduced skeletal ossification was also observed in 6‐OH‐BDE‐47–treated fish. Assessment of thyroid and osteochondral gene regulatory networks demonstrated significantly increased expression of genes that regulate skeletal development and thyroid hormones. Overall, these results indicate that exposures to PBDE/OH‐BDE mixtures adversely impact zebrafish maturation during metamorphosis. Environ Toxicol Chem 2017;36:36–48. © 2016 SETAC Polybrominated diphenyl ethers (PBDEs) and halogenated phenolic compounds (e.g., hydroxylated BDEs (OH-BDEs)) arecontaminants detected together frequently in human tissues, and are structurally similar to thyroid hormones (TH). THs partially mediate metamorphic transitions between life stages in zebrafish, making this a critical developmental window which may be uniquely vulnerable to chemicals disrupting thyroid signaling. In this study, zebrafish were exposed to 6-OH-BDE-47 (30 nM) alone or to a low (30 μg/L) or high dose (600 μg/L) mixture of PentaBDEs, 6-OH-BDE-47 (0.5–6 μg/L), & 2,4,6 tribromophenol (TBP) (5–100 μg/L) during juvenile development (9–23 days post fertilization; dpf) and evaluated for developmental endpoints mediated by TH signaling. Fish were sampled at three time points and examined for developmental and skeletal morphology, apical thyroid and skeletal gene markers, and modifications in swimming behavior (as adults). Exposure to the high mixture resulted in > 85% mortality within one week of exposure, despite being below reported acute toxicity thresholds for individual congeners. The low mixture and 6-OH-BDE-47 groups exhibited reductions in body length and delayed maturation, specifically relating to swim bladder,?, fin, and pigmentation development. Reduced skeletal ossification was also observed in 6-OH-BDE-47 treated fish. Assessment of thyroid and osteochondral gene regulatory networks demonstrated significantly increased expression of genes that regulate skeletal development and THs. Overall, these results indicate that exposures to PBDEs/OH-BDEs mixtures adversely impact zebrafish maturation during metamorphosis. Polybrominated diphenyl ethers (PBDEs) and their metabolites (e.g., hydroxylated BDEs [OH-BDEs]) are contaminants frequently detected together in human tissues and are structurally similar to thyroid hormones. Thyroid hormones partially mediate metamorphic transitions between life stages in zebrafish, making this a critical developmental window that may be vulnerable to chemicals disrupting thyroid signaling. In the present study, zebrafish were exposed to 6-OH-BDE-47 (30nM; 15 mu g/L) alone, or to a low-dose (30 mu g/L) or high-dose (600 mu g/L) mixture of PentaBDEs, 6-OH-BDE-47 (0.5-6 mu g/L), and 2,4,6-tribromophenol (5-100 mu g/L) during juvenile development (9-23d postfertilization) and evaluated for developmental endpoints mediated by thyroid hormone signaling. Fish were sampled at 3 time points and examined for developmental and skeletal morphology, apical thyroid and skeletal gene markers, and modifications in swimming behavior (as adults). Exposure to the high-dose mixture resulted in >85% mortality within 1wk of exposure, despite being below reported acute toxicity thresholds for individual congeners. The low-dose mixture and 6-OH-BDE-47 groups exhibited reductions in body length and delayed maturation, specifically relating to swim bladder, fin, and pigmentation development. Reduced skeletal ossification was also observed in 6-OH-BDE-47-treated fish. Assessment of thyroid and osteochondral gene regulatory networks demonstrated significantly increased expression of genes that regulate skeletal development and thyroid hormones. Overall, these results indicate that exposures to PBDE/OH-BDE mixtures adversely impact zebrafish maturation during metamorphosis. Environ Toxicol Chem 2017; 36:36-48. Polybrominated diphenyl ethers (PBDEs) and their metabolites (e.g., hydroxylated BDEs [OH‐BDEs]) are contaminants frequently detected together in human tissues and are structurally similar to thyroid hormones. Thyroid hormones partially mediate metamorphic transitions between life stages in zebrafish, making this a critical developmental window that may be vulnerable to chemicals disrupting thyroid signaling. In the present study, zebrafish were exposed to 6‐OH‐BDE‐47 (30 nM; 15 μg/L) alone, or to a low‐dose (30 μg/L) or high‐dose (600 μg/L) mixture of PentaBDEs, 6‐OH‐BDE‐47 (0.5–6 μg/L), and 2,4,6‐tribromophenol (5–100 μg/L) during juvenile development (9–23 d postfertilization) and evaluated for developmental endpoints mediated by thyroid hormone signaling. Fish were sampled at 3 time points and examined for developmental and skeletal morphology, apical thyroid and skeletal gene markers, and modifications in swimming behavior (as adults). Exposure to the high‐dose mixture resulted in >85% mortality within 1 wk of exposure, despite being below reported acute toxicity thresholds for individual congeners. The low‐dose mixture and 6‐OH‐BDE‐47 groups exhibited reductions in body length and delayed maturation, specifically relating to swim bladder, fin, and pigmentation development. Reduced skeletal ossification was also observed in 6‐OH‐BDE‐47–treated fish. Assessment of thyroid and osteochondral gene regulatory networks demonstrated significantly increased expression of genes that regulate skeletal development and thyroid hormones. Overall, these results indicate that exposures to PBDE/OH‐BDE mixtures adversely impact zebrafish maturation during metamorphosis. Environ Toxicol Chem 2017;36:36–48. © 2016 SETAC |
| Author | Kullman, Seth W. Stapleton, Heather M. Bailey, Jordan M. Hinton, David E. Macaulay, Laura J. Levin, Edward D. Chen, Albert Chernick, Melissa |
| AuthorAffiliation | Department of Biological Sciences, NC State University, Raleigh, NC 27695 USA Nicholas School of the Environment, Duke University, Durham, NC 27708 USA Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710 USA |
| AuthorAffiliation_xml | – name: Department of Biological Sciences, NC State University, Raleigh, NC 27695 USA – name: Nicholas School of the Environment, Duke University, Durham, NC 27708 USA – name: Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710 USA |
| Author_xml | – sequence: 1 givenname: Laura J. surname: Macaulay fullname: Macaulay, Laura J. organization: Duke University – sequence: 2 givenname: Melissa surname: Chernick fullname: Chernick, Melissa organization: Duke University – sequence: 3 givenname: Albert surname: Chen fullname: Chen, Albert organization: Duke University – sequence: 4 givenname: David E. surname: Hinton fullname: Hinton, David E. organization: Duke University – sequence: 5 givenname: Jordan M. surname: Bailey fullname: Bailey, Jordan M. organization: Duke University Medical Center – sequence: 6 givenname: Seth W. surname: Kullman fullname: Kullman, Seth W. organization: North Carolina State University – sequence: 7 givenname: Edward D. surname: Levin fullname: Levin, Edward D. organization: Duke University Medical Center – sequence: 8 givenname: Heather M. surname: Stapleton fullname: Stapleton, Heather M. email: heather.stapleton@duke.edu organization: Duke University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27329031$$D View this record in MEDLINE/PubMed |
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| Snippet | Polybrominated diphenyl ethers (PBDEs) and their metabolites (e.g., hydroxylated BDEs [OH‐BDEs]) are contaminants frequently detected together in human tissues... Polybrominated diphenyl ethers (PBDEs) and their metabolites (e.g., hydroxylated BDEs [OH-BDEs]) are contaminants frequently detected together in human tissues... Abstract Polybrominated diphenyl ethers (PBDEs) and their metabolites (e.g., hydroxylated BDEs [OH‐BDEs]) are contaminants frequently detected together in... Polybrominated diphenyl ethers (PBDEs) and halogenated phenolic compounds (e.g., hydroxylated BDEs (OH-BDEs)) arecontaminants detected together frequently in... |
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| SubjectTerms | Acute toxicity Adult Animals Contaminants Danio rerio Development Dose-Response Relationship, Drug Ethers Gene Expression - drug effects Halogenated Diphenyl Ethers - metabolism Halogenated Diphenyl Ethers - toxicity Hormones Humans Juvenile Metabolites Metamorphosis Mixture Osteogenesis - drug effects Osteogenesis - genetics Pigmentation Polybrominated Biphenyls - metabolism Polybrominated Biphenyls - toxicity Polybrominated diphenyl ether (PBDE) Polybrominated diphenyl ethers Swimming behavior Thyroid Thyroid gland Thyroid Gland - drug effects Thyroid Gland - metabolism Thyroid Hormones - genetics Thyroid Hormones - metabolism Toxicity Zebrafish Zebrafish - genetics Zebrafish - growth & development Zebrafish - metabolism |
| Title | Exposure to a PBDE/OH‐BDE mixture alters juvenile zebrafish (Danio rerio) development |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fetc.3535 https://www.ncbi.nlm.nih.gov/pubmed/27329031 https://www.proquest.com/docview/1852773582 https://search.proquest.com/docview/1859486008 https://pubmed.ncbi.nlm.nih.gov/PMC5535307 |
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