Nutrients required for phospholipid synthesis are lower in blood and cerebrospinal fluid in mild cognitive impairment and Alzheimer's disease dementia

• Published in: Alzheimer's & dementia : diagnosis, assessment & disease monitoring Vol. 8; no. 1; pp. 139 - 146
• Main Authors: van Wijk, Nick, Slot, Rosalinde E.R, Duits, Flora H, Strik, Marieke, Biesheuvel, Egbert, Sijben, John W.C, Blankenstein, Marinus A, Bierau, Jörgen, van der Flier, Wiesje M, Scheltens, Philip, Teunissen, Charlotte E
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 2017; Elsevier; Wiley
• Subjects: Alzheimer's disease; Blood; Blood Based Biomarkers; Cerebrospinal fluid; Choline; Folate; Homocysteine; Mild cognitive impairment; Neurology; Nutritional status; Other; Phospholipid precursors; Uridine; Phospholipid precursors; Mild cognitive impairment; Choline; Uridine; Cerebrospinal fluid; Homocysteine; Alzheimer's disease; Nutritional status; Folate; Blood

Abstract Introduction Synaptic membrane formation depends on nutrients that fuel metabolic pathways for the synthesis of constituent phospholipids. Consequently, insufficient availability of such nutrients may restrict membrane formation and contribute to synaptic dysfunction in Alzheimer's dis...