Effects of aging on cerebral blood flow, oxygen metabolism, and blood oxygenation level dependent responses to visual stimulation

• Published in: Human brain mapping Vol. 30; no. 4; pp. 1120 - 1132
• Main Authors: Ances, Beau M., Liang, Christine L., Leontiev, Oleg, Perthen, Joanna E., Fleisher, Adam S., Lansing, Amy E., Buxton, Richard B.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2009; Wiley-Liss
• Subjects: Adult; aging; Aging - physiology; Biological and medical sciences; blood oxygen level dependent (BOLD) effect; Brain Mapping; Cardiovascular system; cerebral blood flow (CBF); cerebral metabolic rate of oxygen (CMRO2); Cerebrovascular Circulation - physiology; Female; functional magnetic resonance imaging (fMRI); Humans; Hypercapnia - metabolism; Image Processing, Computer-Assisted - methods; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging - methods; Male; Medical sciences; Middle Aged; Nervous system; Nonlinear Dynamics; Oxygen - blood; Oxygen Consumption - physiology; Photic Stimulation - methods; Radiodiagnosis. Nmr imagery. Nmr spectrometry; visual cortex; Visual Cortex - blood supply; Visual Cortex - physiology; Young Adult; cerebral blood flow (CBF); Visual cortex; Oxygen; Nervous system diseases; Senescence; Radiodiagnosis; Central nervous system; and cerebral metabolic rate of oxygen (CMRO2); functional magnetic resonance imaging (fMRI); Metabolism; Nuclear magnetic resonance imaging; Blood flow; Encephalon; blood oxygen level dependent (BOLD) effect; Visual pathway; Hemodynamics; aging; Oxygenation; Functional imaging

Calibrated functional magnetic resonance imaging (fMRI) provides a noninvasive technique to assess functional metabolic changes associated with normal aging. We simultaneously measured both the magnitude of the blood oxygenation level dependent (BOLD) and cerebral blood flow (CBF) responses in the v...